High-Throughput Synthesis and Screening of Rapidly Degrading Polyanhydride Nanoparticles

Mullis, Adam S.; Jacobson, Sarah J.; Narasimhan, Balaji

doi:10.1021/acscombsci.9b00162

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…PA-based nanoparticles have long been used as vaccine delivery vehicles due to their intrinsic adjuvant properties. − They increase stability for the vaccine associated antigens, modulate the immune response, and allow for the sustained release of the vaccine associated antigens. The use of such biocompatible nanoparticles can eliminate the use of microbially derived adjuvants, as they suffer from high toxicity and other drawbacks .…”

Section: Applicationsmentioning

confidence: 99%

Polyanhydride Chemistry

Reddy

Domb

2022

Biomacromolecules

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Polyanhydrides (PAs) are a class of synthetic biodegradable polymers employed as controlled drug delivery vehicles. They can be synthesized and scaled up from low-cost starting materials. The structure of PAs can be manipulated synthetically to meet desirable characteristics. PAs are biocompatible, biodegradable, and generate nontoxic metabolites upon degradation, which are easily eliminated from the body. The rate of water penetrating into the polyanhydride (PA) matrix is slower than the anhydride bond cleavage. This phenomenon sets PAs as "surface-eroding drug delivery carriers." Consequently, a variety of PA-based drug delivery carriers in the form of solid implants, pasty injectable formulations, microspheres, nanoparticles, etc. have been developed for the sustained release of small molecule drugs, and vaccines, peptide drugs, and nucleic acid-based active agents. The rate of drug delivery is often controlled by the polymer erosion rate, which is influenced by the polymer structure and composition, crystallinity, hydrophobicity, pH of the release medium, device size, configuration, etc. Owing to the above-mentioned interesting physicochemical and mechanical properties of PAs, the present review focuses on the advancements made in the domain of synthetic biodegradable biomedical PAs for therapeutic delivery applications. Various classes of PAs, their structures, their unique characteristics, their physicochemical and mechanical properties, and factors influencing surface erosion are discussed in detail. The review also summarizes various methods involved in the synthesis of PAs and their utility in the biomedical domain as drug, vaccine, and peptide delivery carriers in different formulations are reviewed.

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Section: Applicationsmentioning

confidence: 99%

Polyanhydride Chemistry

Reddy

Domb

2022

Biomacromolecules

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“…The labor and time intensive process of catalyst commercialization motivated the emergence of high-throughput screening − coupled to parallel catalyst preparative methods. − The need for realistic reaction conditions for more focused screening put constraints on preparative methods that hampered serendipitous discovery. Thus, high-throughput screening requires multiple levels of resolution.…”

Section: Introductionmentioning

confidence: 99%

A Laser-Activated Membrane Introduction Mass Spectrometry Study of Proton Spillover Promoted Alkane Dehydrogenation

et al. 2020

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Operando high-throughput evaluation of heterogeneous catalysts by laser-activated membrane introduction mass spectrometry (LAMIMS) elucidates the Pt loading dependence of methylcyclohexane dehydrogenation on platinized γ-alumina beads. A CO2 marking laser rapidly and sequentially heats catalyst beads positioned on a heat-dissipating carbon paper support that overlays a silicone membrane, separating the bead library reaction zone from a quadrupole mass analyzer. The toluene m/z peak varies logarithmically with Pt loading, suggesting that reactivity includes factors that are negatively correlated to Pt loading. These factors may include the Pt/γ-Al2O3 surface interfacial region as one component of a heterogeneous catalytically active surface area/mass. This work demonstrates LAMIMS as a broadly applicable high-throughput operando screening method for heterogeneous catalysts.

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“…(Table 2.2) [361,362] Degradation kinetics can therefore be tailored by controlling the polymer hydrophobicity through diacid composition, causing sustained release to occur over days to years. [363][364][365] Surface erosion also has significant consequences for preservation of antigenicity, by excluding water from the bulk particle, polyanhydride nanoparticles protect labile proteins from water and from polymer degradation products. [366] Additionally, polyanhydride diacids are less acidic than PLGA monomers, thereby avoiding a detrimental microenvironment.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Universal room-temperature stable influenza A nanovaccine

Siddoway

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1. When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong.2. The only way of discovering the limits of the possible is to venture a little way past them into the impossible. Any sufficiently advanced technology is indistinguishable from magic.These laws can be interpreted in any number of ways; charitably as value of optimism and perseverance, or facetiously as 'no one really knows.' Regardless of Clarke's true intentions, the flexible interpretations portray the unstable intellectual and emotion path a graduate student must walk. Truly, without a generous support network, this journey is impossible.To this point, first and foremost I would like to thank my family. My parents, who have always listened, cared and nurtured. I don't pretend to understand the love a parent has for their child, especially a sassy one, but I am deeply grateful for it. Without your support, I could not have done this. My sisters and their husbands, I always appreciated the visits, calls and messages. The little acts of kindness made all the difference to me. v I cannot express my gratitude for my advisors, Balaji Narasimhan and Surya Mallapragada. I aspire to have the patient, pragmatic and level-headed attitude that you always displayed. Thank you for being exceptional examples. I would also like to thank Dr. David Verhoeven for all of his advice, teaching and support. Through our many conversations, you have always encouraged critical discussion and thoughtful approaches. I would also like to thank all of my friends and colleagues in Chemical Engineering and Immunobiology departments, particularly those on the 5 th floor of the Advanced Teaching and Research Building. I appreciate Dr. Michael Wannemuehler for simultaneously entertaining our floor and starting insightful discussions. A special thank you to Dr. Kathleen Ross for her expertise, support and friendship. I would like to express my appreciation Dr. Sean Kelly for exemplifying what it means to think outside the box and how to stay endlessly positive. Additionally, thank you to Dr. Adam Mullis for teaching by example, demonstrating the difference between skepticism and cynicism, and giving me both the impetus and the means to find a work-life balance. Finally, I gratefully acknowledge the financial support from the National Institute of Health and the National Institute of Allergy and Infectious Diseases (R01 AI141196).

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High-Throughput Synthesis and Screening of Rapidly Degrading Polyanhydride Nanoparticles

Cited by 7 publications

References 43 publications

Polyanhydride Chemistry

Polyanhydride Chemistry

A Laser-Activated Membrane Introduction Mass Spectrometry Study of Proton Spillover Promoted Alkane Dehydrogenation

Universal room-temperature stable influenza A nanovaccine

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