High-throughput untargeted metabolomics and chemometrics reveals pharmacological action and molecular mechanism of chuanxiong by ultra performance liquid chromatography combined with quadrupole-time-of-flight-mass spectrometry

Luo, Wen; Zhang, Jiawen; Zhang, Lijuan; Zhang, Wei

doi:10.1039/c9ra06267j

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Metabolite Analysis1

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2020

2023

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Cited by 4 publications

(2 citation statements)

References 91 publications

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“…The intermediate products of glycerol phospholipid metabolism were transformed into the components of cell membrane (Table 4). 64,65…”

Section: Metabolite Analysismentioning

confidence: 99%

Effect of soybean oligopeptide on the growth and metabolism of Lactobacillus acidophilus JCM 1132

Zhang

et al. 2020

RSC Adv.

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“…The intermediate products of glycerol phospholipid metabolism were transformed into the components of cell membrane (Table 4). 64,65…”

Section: Metabolite Analysismentioning

confidence: 99%

Effect of soybean oligopeptide on the growth and metabolism of Lactobacillus acidophilus JCM 1132

Zhang

et al. 2020

RSC Adv.

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“…It is similar to the theory of traditional Chinese medicines (TCM) "multi-component, multi-target, overall regulation". Therefore, using metabolomic methods to explore the changes of metabolites under TCM intervention can provide clues to the action mechanism of TCM (Luo et al, 2019;Hou et al, 2021;Pan et al, 2021;Li et al, 2022). In this study, the anticancer effects of OJ against NCI-H1299 cells were evaluated.…”

Section: Introductionmentioning

confidence: 99%

Cell metabolomics study on the anticancer effects of Ophiopogon japonicus against lung cancer cells using UHPLC/Q-TOF-MS analysis

Shen

Hong

et al. 2022

Front. Pharmacol.

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Ophiopogon japonicus (OJ) is a traditional Chinese herbal medicine that has been used for thousands of years. Recently, the anticancer effects of OJ have been reported in multiple types of cancer, particularly in lung cancer. However, the underlying mechanisms remain unclear. In present study, the effects of OJ against NCI-H1299 human lung cancer cells were investigated, and the underlying mechanisms were explored using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS)-based cell metabolomics. As a result, OJ inhibited the proliferation, induced the apoptosis and suppressed the migration of NCI-H1299 cells. A total of 22 differential metabolites responsible for the effects of OJ were screened and annotated based on the LC-MS-based cell metabolomics approach. The altered metabolites were involved in three metabolic pathways, including glycerophospholipid metabolism, ether lipid metabolism and glutathione metabolism. These results showed that cell metabolomics-based strategies are promising tools to discover the action mechanisms of OJ against lung cancer cells.

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Molecular and metabolic mechanisms of bufalin against lung adenocarcinoma: New and comprehensive evidences from network pharmacology, metabolomics and molecular biology experiment

Shi

Zhao

Tian

et al. 2023

Computers in Biology and Medicine

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High-throughput untargeted metabolomics and chemometrics reveals pharmacological action and molecular mechanism of chuanxiong by ultra performance liquid chromatography combined with quadrupole-time-of-flight-mass spectrometry

Abstract: Metabolomics methods can be used to explore the effect mechanisms underlying treatments with traditional medicine.

Cited by 4 publications

References 91 publications

Effect of soybean oligopeptide on the growth and metabolism of Lactobacillus acidophilus JCM 1132

Effect of soybean oligopeptide on the growth and metabolism of Lactobacillus acidophilus JCM 1132

Cell metabolomics study on the anticancer effects of Ophiopogon japonicus against lung cancer cells using UHPLC/Q-TOF-MS analysis

Molecular and metabolic mechanisms of bufalin against lung adenocarcinoma: New and comprehensive evidences from network pharmacology, metabolomics and molecular biology experiment

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