High Torquetenovirus Loads Are Correlated With Bronchiectasis and Peripheral Airflow Limitation in Children

Abstract

This study demonstrated the high prevalence of TTV infection in children with bronchiectasis. Moreover, we have shown a significant correlation between TTV loads and airflow limitation within the peripheral airways, as well as between severity of bronchiectasis and decrease of lung function.

Torquetenovirus Infection and Ciliary Dysmotility in Children With Recurrent Pneumonia

“…38 More recently we confirmed the association between reduced lung function and TTV load in children with bronchiectasis suggesting a possible copathogenetic role of this viral infection in the induction of airway damage. 39 In conclusion, the new findings of epithelial cell disruption with reduced CBF in relation to TTV load in children with recurrent-persistent pneumonia add another piece in the complex puzzle of the TT virus infection-host relationship and strengthen our previous observations on the possible role of TTV in the pathogenesis of acute and chronic respiratory diseases in children. However, further studies on what consequences TTV induces on the respiratory cells in terms of enzyme production, cellular receptor expression and cell signaling pathway modification are needed.…”

New respiratory viral infections

“…Moreover, a single TTV strain may persist for years causing chronic viremia, and there may be multiple simultaneous infections by different TTV variants [109][110][111]. Particularly high TTV loads in nasal secretions or plasma have positively correlated with markers of eosinophilic inflammation, severities of bronchiectasia disease and idiopathic pulmonary fibrosis, congenital mannose-binding lectin deficiencies, and autoimmune rheumatoid disease, and inversely with pulmonary function in asthma [112][113][114][115][116]. These associations could be based on a direct viral effect or be mediated by inflammatory processes that predispose to virus replication.…”

Case Studies of the Spatial Heterogeneity of DNA Viruses in the Cystic Fibrosis Lung

“…Although TTV and other anelloviruses were found to be associated with respiratory disease, bronchiectasis, and loss of lung function, whether TTV plays a specific role in CF remains unknown (28).…”