High Total and Cardiovascular Disease Mortality in Adults of Indian Descent in Trinidad, Unexplained by Major Coronary Risk Factors

Beckles, Gloria L.; Kirkwood, Betty; Carson, D C; Miller, George; Alexis, Samuel; Byam, N T A

doi:10.1016/s0140-6736(86)91221-3

Cited by 154 publications

(69 citation statements)

References 12 publications

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“…High levels of CHD and of coronary and diabetic risk factors have been consistently noted among South Asians overseas communities (McKeigue et al, 1989;Vardan et al, 1995;Balarajan, 1996;Wild & McKeigue, 1997). This has been demonstrated in areas as diverse as Trinidad (Beckles et al, 1986), the UK (Dhawan et al, 1994), Singapore (Hughes et al, 1990), Figi (Sorokin, 1973) and Uganda (Shaper & Jones, 1959). Risk of CHD among South Asians has been demonstrated to be higher than that of the host society to which they have migrated (Balarajan, 1991).…”

Section: Introductionmentioning

confidence: 97%

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Mahajan

Bermingham

2004

Eur J Clin Nutr

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Objective: To identify the prevalence of coronary risk factors among South Asian Indians in Australia and India. Design: Cross-sectional intercountry comparison. Subjects: Healthy volunteers aged 23-75 y recruited from the Indian community in Sydney Australia (n¼125), and their nominated relatives in India, (n¼125). Results: The two groups were of similar background with over 90% of the group in India being siblings, parents or relatives of the group in Australia. There was no difference in the populations between India and Australia with regard to mean age (40711.5 vs 39710. Conclusion:The group in Australia (especially women) have a more favourable disease risk profile than those in India. The fact that the groups are of such similar background and partly related, make it unlikely that changes due to migration have a strong genetic bias. In contrast to other studies, the absence here of excessive weight gain on migration may be a key factor in disease risk prevention.

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Section: Introductionmentioning

confidence: 97%

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Mahajan

Bermingham

2004

Eur J Clin Nutr

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“…This 'epidemiologic' transition is characterized by a higher incidence of coronary heart diseases (CHD), particularly among South Asians (Beckles et al 1986;McKeigue et al 1989). There are various mechanisms that favour epidemics of CHD.…”

Section: Introductionmentioning

confidence: 99%

Urban living and obesity: is it independent of its population and lifestyle characteristics?

Arambepola

Allender

Ekanayake

et al. 2008

Tropical Med Int Health

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Summaryobjectives Living in an urban area influences obesity. However, little is known about whether this relationship is truly independent of, or merely mediated through, the demographic, socio-economic and lifestyle characteristics of urban populations. We aimed to identify and quantify the magnitude of this relationship in a Sri Lankan population.methods Cross-sectional study of adults aged 20-64 years representing the urban (n = 770) and rural (n = 630) populations, in the district of Colombo in 2004. Obesity was measured as a continuous variable using body mass index (BMI). Demographic, socio-economic and lifestyle factors were assessed. Gender-specific multivariable regression models were developed to quantify the independent effect of urban ⁄ rural living and other variables on increased BMI. conclusions Urban living is associated with obesity independently of most other demographic, socioeconomic and lifestyle characteristics of the population. Targeting urban populations may be useful for consideration when developing strategies to reduce the prevalence of obesity.

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“…Low levels of HDL-C are an important risk factor for CAD (Beckles et al, 1986;Enas et al, 1996). Plasma concentrations of HDL-C are influenced by both genetic and lifestyle factors.…”

Section: Introductionmentioning

confidence: 99%

Dietary carbohydrates, glycemic load and serum high-density lipoprotein cholesterol concentrations among South Indian adults

et al. 2007

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Objective: To examine the relationship between dietary carbohydrates, glycemic load and high-density lipoprotein cholesterol (HDL-C) concentrations in Asian Indians, a high-risk group for diabetes and premature coronary artery disease. Subjects/methods: The study population comprised of 2043 individuals aged X20 years randomly selected from Chennai Urban Rural Epidemiological Study (CURES), an ongoing population-based study on a representative population of Chennai (formerly Madras) city in southern India. Participants with self-reported history of diabetes or heart disease or on drug therapy for dyslipidemia were excluded from the study. Dietary carbohydrates, glycemic index and glycemic load were assessed using a validated interviewer administered semiquantitative Food Frequency Questionnaire (FFQ). Results: Both dietary glycemic load (Po0.0001) and total dietary carbohydrate intake (Po0.001) were significantly associated with higher serum triglyceride levels and lower serum HDL-C levels. For the lowest to highest quintile of glycemic load, the multivariate-adjusted mean HDL-C values were 44.1 mg per 100 ml and 41.2 mg per 100 ml (6.6% difference, P for trendo0.001), while for total carbohydrate it was less (5% difference, P for trend ¼ 0.016). The pattern of decrease in HDL-C for the lowest to highest quintile of glycemic load was more pronounced among men (1st vs 5th quintile: adjusted HDL-C: 4.3 mg per 100 ml decrease (10.3%)) than women (1st vs 5th quintile: adjusted HDL-C: 3.2 mg per 100 ml decrease (6.9%)). Conclusion: Our findings indicate that both total carbohydrates and dietary glycemic load intake are inversely associated with plasma HDL-C concentrations among Asian Indians, with dietary glycemic load having a stronger association.

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High Total and Cardiovascular Disease Mortality in Adults of Indian Descent in Trinidad, Unexplained by Major Coronary Risk Factors

Cited by 154 publications

References 12 publications

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Urban living and obesity: is it independent of its population and lifestyle characteristics?

Dietary carbohydrates, glycemic load and serum high-density lipoprotein cholesterol concentrations among South Indian adults

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