High toxicity of Bi(OH)3 and α-Bi2O3 nanoparticles towards malignant 9L and MCF-7 cells

Bogusz, Kathrin; Tehei, Moeava; Cardillo, Dean; Lerch, Michael L. F; Rosenfeld, Anatoly B.; Dou, Shi Xue; Liu, Huan; Konstantinov, Konstantin

doi:10.1016/j.msec.2018.09.001

Cited by 16 publications

(22 citation statements)

References 52 publications

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“…Moreover, Zn-doping increases the cytotoxicity of Bi 2 O 3 NPs in cancer cells and improves their biocompatibility in normal cells. High toxicity of Bi(OH) 3 and Bi 2 O 3 NPs in gliosarcoma 9L cells and human breast cancer MCF-7 cells and low toxicity in normal cells were also reported by Bogusz et al…”

Section: Resultssupporting

confidence: 63%

“…Earlier studies have shown that ZnO NPs have inherent potential of killing cancer cells through ROS while sparing the normal cells. , Some previous reports also demonstrated that Bi-based nanoscale materials selectively induce cytotoxicity to cancer cells via ROS without much affecting the normal cells. , ROS-induced oxidative stress has been also suggested as one of the potential mechanisms of selective cytotoxicity of cancer cells by other semiconductor NPs. , Hence, we further explored the potential mechanisms of anticancer activity and biocompatibility of Zn-doped Bi 2 O 3 NPs. Intracellular generation of ROS in cancer cells (A459 and HepG2) and primary rat hepatocytes following exposure to moderate concentration of (50 μg/mL) of 3% Zn–Bi 2 O 3 NPs for 24 h was examined.…”

Section: Resultsmentioning

confidence: 93%

“…17,36 Some previous reports also demonstrated that Bi-based nanoscale materials selectively induce cytotoxicity to cancer cells via ROS without much affecting the normal cells. 33,35 ROS-induced oxidative stress has been also suggested as one of the potential mechanisms of selective cytotoxicity of cancer cells by other semiconductor NPs. 37,38 Hence, we further explored the potential mechanisms of anticancer activity and biocompatibility of Zn-doped Bi 2 O 3 NPs.…”

Section: Introductionmentioning

confidence: 99%

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Facile Synthesis of Zn-Doped Bi₂O₃ Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells

et al. 2021

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Bismuth (III) oxide nanoparticles (Bi 2 O 3 NPs) have shown great potential for biomedical applications because of their tunable physicochemical properties. In this work, pure and Zn-doped (1 and 3 mol %) Bi 2 O 3 NPs were synthesized by a facile chemical route and their cytotoxicity was examined in cancer cells and normal cells. The X-ray diffraction results show that the tetragonal phase of β-Bi 2 O 3 remains unchanged after Zn-doping. Transmission electron microscopy and scanning electron microscopy images depicted that prepared particles were spherical with smooth surfaces and the homogeneous distribution of Zn in Bi 2 O 3 with highquality lattice fringes without distortion. Photoluminescence spectra revealed that intensity of Bi 2 O 3 NPs decreases with increasing level of Zn-doping. Biological data showed that Zn-doped Bi 2 O 3 NPs induce higher cytotoxicity to human lung (A549) and liver (HepG2) cancer cells as compared to pure Bi 2 O 3 NPs, and cytotoxic intensity increases with increasing concentration of Zn-doping. Mechanistic data indicated that Zn-doped Bi 2 O 3 NPs induce cytotoxicity in both types of cancer cells through the generation of reactive oxygen species and caspase-3 activation. On the other hand, biocompatibility of Zn-doped Bi 2 O 3 NPs in normal cells (primary rat hepatocytes) was greater than that of pure Bi 2 O 3 NPs and biocompatibility improves with increasing level of Zn-doping. Altogether, this is the first report highlighting the role of Zn-doping in the anticancer activity of Bi 2 O 3 NPs. This study warrants further research on the antitumor activity of Zn-doped Bi 2 O 3 NPs in suitable in vivo models.

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Section: Resultssupporting

confidence: 63%

Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Facile Synthesis of Zn-Doped Bi₂O₃ Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells

et al. 2021

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“…It is meaningful to understand the possible mechanisms explaining how the ITO NPs mediate the intracellular ROS generation or scavenging. Although the exact mechanisms of the ITO NP-mediated ROS induction are still unknown, there are a number of studies that have demonstrated that metal oxide NPs are able to induce ROS generation in cancer cells. − ,,, In addition, ITO NPs have also been reported to be able to promote the production of intracellular ROS in A549 human lung adenocarcinoma cells . On the basis of our results, we postulate that the ITO NPs contain abundant oxygen defects and may have mixed In +2 /In +3 valence states.…”

Section: Resultsmentioning

confidence: 50%

Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress

Hsu

Tehei

Hossain

et al. 2021

ACS Appl. Mater. Interfaces

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“…The suspended exposed cells were used for measurement of protein amount, GSH content and antioxidant enzyme levels. The amount of protein was measured by Bradford (1976) method. The GSH, CAT and SOD levels were determined by ELISA kit (SunRed Biological Technology, Shanghai, PRC), based on biotin double antibody sandwich technology, according to the manufacturer' s instructions.…”

Section: Evaluation Of Oxidative Damage Potentialmentioning

confidence: 99%

Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line

Öztaş¹,

Asadi²,

Aykanat³

et al. 2019

Istanbul J Pharm

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Nanoparticles, chemical structures between 1-100 nm in size, are one of the most promising elements of a new era in technology and science. NPs-based products are growing rapidly in a variety of fields such as health and fitness, electronics and computers, cosmetics, home and garden, food and beverage as well as biomedical applications (Mnyusiwalla et al. 2003; EPA, 2007). The Nanotechnology Consumer Products Inventory report, released in October 2013, listed 1814 nano-containing consumer products, in which the largest group of these products (37%) contains metals and metal oxides NPs (Vance et al. 2015). NPs potentially cause harm to both humans and the environment due to their unique physicochemical properties, size, shape and solubility (Maynard et al. 2006). NPs can easily penetrate the cell membrane due to their very small size and alter the crucial functions of cells. Growing evidence shows that various molecular mechanisms such as DNA damage, oxidative stress, mitochondrial disruption, apoptosis resulting in morphological changes and eventually cell death are responsible for the toxic effects of NPs (Ray et al. 2009; Dhawan and Sharma, 2010; Iavicoli et al. 2013).Bi 2 O 3 is one of the significant metal oxides which has rapidly attracted attention, perhaps because of its use in technology, industry and biomedical sciences (Hyodo et al. 2000; Rabin et al. 2006; Taufik et al. 2011). Despite Bi 2 O 3 -NPs widespread usages and the increasing intentional or unintentional exposure, there is limited knowledge about their toxicity (Thomas et al. 2012; Hernandez-Delgadillo et

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High toxicity of Bi(OH)3 and α-Bi2O3 nanoparticles towards malignant 9L and MCF-7 cells

Cited by 16 publications

References 52 publications

Facile Synthesis of Zn-Doped Bi₂O₃ Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells

Facile Synthesis of Zn-Doped Bi₂O₃ Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells

Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress

Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line

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High toxicity of Bi(OH)3 and α-Bi2O3 nanoparticles towards malignant 9L and MCF-7 cells

Cited by 16 publications

References 52 publications

Facile Synthesis of Zn-Doped Bi2O3 Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells

Facile Synthesis of Zn-Doped Bi2O3 Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells

Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress

Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line

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Facile Synthesis of Zn-Doped Bi₂O₃ Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells

Facile Synthesis of Zn-Doped Bi₂O₃ Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells