High urinary ACE2 concentrations are associated with severity of glucose intolerance and microalbuminuria

Park, Se Eun; Kim, Won Jun; Park, Sung Woo; Park, Ji Woo; Lee, Namseok; Park, Cheol‐Young; Youn, Byung-Soo

doi:10.1530/eje-12-0782

Cited by 41 publications

(55 citation statements)

References 47 publications

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“…A majority of studies, except the one from Ye M, have confirmed that tubular ACE2 decreased significantly in diabetic patients and animal models [7,8,9]. On the other hand, UACE2 excretion significantly increased in uncomplicated type 1 diabetic patients, insulin-resistant subjects, CKD patients and renal transplant recipients, indicating it might be a potential marker for diabetes and kidney disease [13,14,15,23]. Consistent with these studies, we showed that UACE2/Cr levels were much higher in type 2 DN patients.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, soluble ACE2 in urine, which is most likely due to proteolytic shedding of its ectodomain from cells along the nephron, has been detected in several clinical and experimental studies [13,14,15,16,17]. It was reported that urinary ACE2 (UACE2) levels were significantly increased in patients with chronic kidney disease (CKD) and in renal transplant recipients compared with healthy subjects [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that urinary ACE2 (UACE2) levels were significantly increased in patients with chronic kidney disease (CKD) and in renal transplant recipients compared with healthy subjects [13,14]. In a more recent study, Park and colleagues demonstrated that UACE2 levels were much higher in insulin-resistant subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) than in the normal glucose tolerance (NGT) group [15]. Moreover, a positive relationship between mRNA expression of ACE2 in urinary cell pellets and the degree of proteinuria was observed in patients with type 2 DN [18].…”

Section: Introductionmentioning

confidence: 99%

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Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus

Liang¹,

Deng²,

Bi³

et al. 2015

Kidney Blood Press Res

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Background/Aims: Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate UACE2 levels in type 2 diabetic patients with various degrees of albuminuria and its associations with metabolic parameters. The effect of RAS inhibitors on UACE2 excretion was also assessed. Methods: A total of 132 type 2 diabetic patients with different degrees of albuminuria and 34 healthy volunteers were studied. UACE2 levels and activity were measured. Results: Compared to healthy controls, UACE2 to creatinine (UACE2/Cr) levels were significantly increased in both albuminuric and non-albuminuric diabetic patients. UACE2/Cr levels were much higher in hypertensive diabetic patients compared with their normotensive counterparts and treatment with RAS inhibitors markedly attenuated the augmentation. Furthermore, UACE2/Cr was positively correlated with fasting blood glucose, hemoglobin A1C (HbA1C), triglyceride, and total cholesterol. In multiple regression analysis, UACE2/Cr was independently predicted by HbA1C and RAS inhibitors treatment. Conclusions: UACE2 increased in type 2 diabetic patients with various degrees of albuminuria and RAS inhibitors suppresses UACE2 excretion. UACE2 might potentially function as a marker for monitoring the metabolic status and therapeutic response of RAS inhibitors in diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus

Liang¹,

Deng²,

Bi³

et al. 2015

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…While it is not known whether it is similarly protective in humans, ACE2 is detectable in human urine (Park et al 2013) and, as determined using enzyme-linked immunosorbent assay (ELISA), urinary ACE2 protein levels are found to be higher in patients with CKD, as well as in renal-transplant patients with diabetes (Mizuiri et al 2011;Xiao et al 2012). In patients with type 2 diabetes (T2D), Park et al have further demonstrated that urinary ACE2 is increased and independently associated with microalbuminuria (Park et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…In patients with type 2 diabetes (T2D), Park et al have further demonstrated that urinary ACE2 is increased and independently associated with microalbuminuria (Park et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Urinary ACE2 in healthy adults and patients with uncomplicated type 1 diabetes

Cherney

Xiao

Zimpelmann

et al. 2014

Can. J. Physiol. Pharmacol.

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Angiotensin-converting enzyme 2 (ACE2) is expressed in the kidney and may be renoprotective. We determined whether urinary ACE2 enzyme activity and protein levels (ELISA), as well as angiotensinogen and ACE, are elevated during clamped euglycemia (4-6 mmol·L(-1)) in patients with uncomplicated type 1 diabetes (T1D, n = 58) compared with normoglycemic controls (n = 21). We also measured the effect of clamped hyperglycemia (9-11 mmol·L(-1)) on each urinary factor in T1D patients. Urinary ACE2 activity and protein levels were higher during clamped euglycemia in T1D compared with the controls (p < 0.0001). In contrast, urinary angiotensinogen levels (p = 0.27) and ACE excretion (p = 0.68) did not differ. In response to clamped hyperglycemia in T1D, urinary ACE2 protein decreased (p < 0.0001), whereas urinary ACE2 activity as well as angiotensinogen and ACE levels remained unchanged. Urinary ACE2 activity and protein expression are increased in T1D patients prior to the onset of clinical complications. Further work is required to determine the functional role of urinary ACE2 in early T1D.

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SARS-CoV-2 (COVID-19): Beginning to Understand a New Virus

Giau

Bagyinszky

Park

et al. 2021

Clinical, Biological and Molecular Aspects of COVID-19

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High urinary ACE2 concentrations are associated with severity of glucose intolerance and microalbuminuria

Abstract: Our data suggest that the urinary ACE2 level is closely associated with T2DM and is an independent risk factor for microalbuminuria.

Cited by 41 publications

References 47 publications

Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus

Urinary Angiotensin Converting Enzyme 2 Increases in Patients With Type 2 Diabetic Mellitus

Urinary ACE2 in healthy adults and patients with uncomplicated type 1 diabetes

SARS-CoV-2 (COVID-19): Beginning to Understand a New Virus

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