High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Ohata, Kazuyuki; Hamasaki, Koji; Toriyama, Kan; Ishikawa, Hiroki; Nakao, Kazuwa; Eguchi, Katsumi

doi:10.1111/j.1440-1746.2004.03360.x

Cited by 97 publications

(61 citation statements)

References 40 publications

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“…Our findings are partly consistent with studies in different areas. In Japan, Ohata et al [25] have investigated the risk factors for HCC in 73 patients with HBV-associated liver disease. A high viral load of HBV DNA, together with age and histological fibrosis, were found to be linked to the occurrence of HCC.…”

Section: Discussionmentioning

confidence: 99%

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

Liu¹,

Fāng²,

Xiong³

et al. 2008

WJG

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AIM:To investigate the role of hepatitis B virus (HBV) replication in the development of hepatocellular carcinoma (HCC), a nested case-control study was performed to study the relationship between HBV DNA level and risk of HCC. METHODS:One hundred and seventy cases of HCC and 276 control subjects free of HCC and cirrhosis were selected for this study. Serum HBV DNA level was measured using fluorescein quantitative polymerase chain reaction at study entry and the last visit. RESULTS:In a binary unconditional logistic regression analysis adjusted for age, cigarette smoking, alcohol consumption and family history of chronic liver diseases, the adjusted odds ratios (95% confidence intervals) of HCC in patients with increasing HBV DNA level were 2.834 (1.237-6.492), 48.403 (14.392-162.789), 42.252 (14.784-120.750), and 14.819 (6.992-31.411) for HBV DNA levels ≥ 10 4 to < 10 5 ; ≥ 10 5 to < 10 6 ; ≥ 10 6 to < 10 7 ; ≥ 10 7 copies/mL, respectively. Forty-six HCC cases were selected to compare the serums viral loads of HBV DNA at study entry with those at the last visit. The HBV DNA levels measured at the two time points did not differ significantly.

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Section: Discussionmentioning

confidence: 99%

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

Liu¹,

Fāng²,

Xiong³

et al. 2008

WJG

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show abstract

“…Further, none of the six patients in the inactive replication group developed end stage liver diseases such as cirrhosis and hepatocellular carcinoma after the follow-up period, while 4 of the 18 patients in the active replication group developed them (data not shown). High viral load, which is usually associated with active hepatitis, has been reported to be a risk factor for development of hepatocellular carcinoma even in patients with chronic hepatitis B who achieved HBe antigen seroconversion [Ikeda et al, 2003;Ohata et al, 2004]. We could not compare long-term prognosis between patients in the inactive and active replication groups in the present study.…”

Section: Discussionmentioning

confidence: 74%

Patients with and without loss of hepatitis B virus DNA after hepatitis B e antigen seroconversion have different virological characteristics

Misawa

Matsumoto

Tanaka

et al. 2005

Journal of Medical Virology

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The characteristic differences between patients with and without loss of hepatitis B virus (HBV) DNA after achieving hepatitis B e antigen seroconversion were analyzed by comparing changes in HBV DNA and HBV core-related antigen levels during a period from 3 years before to 3 years after the seroconversion. Of the 24 seroconverters, 6 (inactive replication group) showed continuous loss of HBV DNA in serum after the seroconversion and the remaining 18 did not lose HBV DNA (active replication group). The HBV DNA level was similar between the two groups, while the HBV core-related antigen level was significantly lower in the active replication group than in the inactive replication group before the seroconversion. The levels of both HBV DNA and HBV core-related antigen decreased remarkably around the time of seroconversion in the inactive replication group, while these levels did not change or decreased slightly in the active replication group. After the seroconversion, the HBV DNA level was significantly higher in the active replication group than in the inactive replication group, while the HBV core-related antigen level was similarly low between the two groups. Because the serum level of HBV core-related antigen mainly reflects that of HBe antigen, the low level of HBV core-related antigen seen after seroconversion in both groups might have contributed to the occurrence of seroconversion. The precore and core promoter mutations which cause diminished excretion of hepatitis B e antigen were significantly more frequent in the active replication group than in the inactive replication group. It was therefore considered that the seroconversion was caused mainly by a decrease in viral replication in the inactive replication group, and mainly by a decrease in HBe antigen production in the active replication group.

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“…39 Studies have confirmed that high HBV viral load is a major risk factor for the development of HCC in patients with chronic HBV infection and is also a risk factor for recurrence after resection. [40][41][42][43] Recent large prospective studies have confirmed that coffee consumption decreases the risk of liver cancer, 4 4-4 6 however, it has not been determined that coffee drinking really decrease the incidence of HCC. Other risk factors for development of HCC, including obesity and type 2 diabetes, have been described elsewhere.…”

Section: Natural History Of Hccmentioning

confidence: 99%

Hepatocellular Carcinoma in Keio Affiliated Hospitals — Diagnosis, Treatment, and Prognosis of this Disease —

Saito

Masuda²,

Tada³

et al. 2009

Keio J. Med.

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High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Abstract: The present findings indicate that high viral load is a risk factor for HCC in patients with chronic HBV infection. Patients with a high HBV viral load should be carefully monitored for HCC.

Cited by 97 publications

References 40 publications

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

Patients with and without loss of hepatitis B virus DNA after hepatitis B e antigen seroconversion have different virological characteristics

Hepatocellular Carcinoma in Keio Affiliated Hospitals — Diagnosis, Treatment, and Prognosis of this Disease —

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