High Viscosity Slows the Utilization of Rapidly Fermentable Dietary Fiber by Human Gut Microbiota

He, Xiangxiang; Sun, Cuixia; Zhao, Jingwen; Zhang, Yin; Zhang, Xiaowei; Fang, Yapeng

doi:10.1021/acs.jafc.3c05652

Cited by 3 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that the effect of fib-CNF on intestinal bacteria led to weight loss. Numerous studies and review articles discuss the degradation of cellulose and other dietary fibers by intestinal bacteria [24][25][26][27][28][29][30][31][32][33][34]. Although cellulose is a central component of plant fiber and is abundant in diets with plant-derived foods, humans, like other mammals, rely on gut microbiota to break down cellulose.…”

Section: Discussionmentioning

confidence: 99%

A 28-Day Repeated Oral Administration Study of Mechanically Fibrillated Cellulose Nanofibers According to OECD TG407

Yamashita,

Tokunaga,

Aoki

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

The impact of oral administration of mechanically fibrillated cellulose nanofibers (fib-CNF), a commonly used nanofiber, on toxicity and health remains unclear, despite reports of the safety and beneficial effects of chitin-based nanofibers. Thus, evaluating the oral toxicity of fib-CNF in accordance with OECD Test Guideline 407 (TG407) is essential. This study aimed to assess the safety of orally administered fib-CNF through an acute toxicity study in rats, following the OECD TG407 guidelines for 4 weeks. CNF “BiNFi-s” FMa-10005, derived from mechanically fibrillated pulp cellulose, was administered via gavage to male and female Crl:CD(SD) rats at doses of 50, 150, 500, and 1000 mg/kg/day for 28 days, with a control group receiving water for injection. The study evaluated the toxic effects of repeated administration, and the rats were monitored for an additional 14 days post-administration to assess recovery from any toxic effects. The results showed no mortality in either sex during the administration period, and no toxicological effects related to the test substance were observed in various assessments, including general condition and behavioral function observations, urinalysis, hematological examination, blood biochemical examination, necropsy findings, organ weights, and histopathological examination. Notably, only female rats treated with 1000 mg/kg/day of CNF exhibited a consistent reduction in body weight during the 14-day recovery period after the end of treatment. They also showed a slight decrease in pituitary and liver weights. However, hematological and blood biochemical tests did not reveal significant differences, suggesting a potential weight-suppressive effect of CNF ingestion.

show abstract