High vitamin E and selenium elevate, whereas diphenyl-para-phenylenediamine plus caffeine lowers liver fat in alcohol-fed rats

Nolan, Bonnie; Hess, Marie; Howell, Amy B.; Martin, Joseph V.; Wagner, George C.; Fisher, Hans

doi:10.1016/j.nutres.2005.07.004

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…Although selenium typically demonstrates hypolipemic action, 49 in large doses it can have the opposite effect and raise the concentration of lipids in serum. Bleys et al 50 in studies on a representative US population observed a strong correlation between high selenium concentration in serum and high concentration of total cholesterol, HDL, triglycerides and apolipoproteins: apo A and apo B; therefore, according to the authors the supplements containing selenium should be screened for their impact on lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Influence of selenium and/or magnesium on alleviation alcohol induced oxidative stress in rats, normalization function of liver and changes in serum lipid parameters

et al. 2011

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The aim of this study was to evaluate the attenuating effect of given selenium and/or magnesium on ethanol-induced oxidative stress, disturbances of liver function and cholesterol metabolism. Forty male rats were divided into five groups: C – control, Et – intoxicated with alcohol (15% solution in drinking water), Et + Mg, Et + Se, Et + Mg + Se – intoxicated with alcohol and supplemented with selenium (0.4 mg Se/l water), magnesium (100 mg Mg/l water) and combination of Se and Mg, respectively. The experiment was carried out over the 3 months. The results show that the chronic ingestion of alcohol induces lipid peroxidation and histopathological changes in liver. Supplementation with magnesium only partially alleviates oxidative stress and damages in this tissue. The both selenium alone and combination of magnesium and selenium significantly elevated total antioxidant status (TAS) in serum, activity of glutathione peroxidase and ratio of reduced glutathione to oxidized glutathione (GSH/GSSG) in liver and retarded oxidative stress and histopathological changes in this tissue. Chronic administration of ethanol (alone and with magnesium) resulted in significant decrease in the serum total cholesterol and retardation in the body weight gain in comparison with the control group. In the groups supplemented with selenium and selenium and magnesium simultaneously, concentration of total cholesterol in serum and body gains was similar to the control group. Supplementation of Se or selenium and magnesium simultaneously significantly enhances antioxidant defence and is more effective against alcohol-induced oxidative stress, disturbance of liver function and cholesterol metabolism than the separate use of magnesium.

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Section: Discussionmentioning

confidence: 99%

Influence of selenium and/or magnesium on alleviation alcohol induced oxidative stress in rats, normalization function of liver and changes in serum lipid parameters

et al. 2011

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“…Some literatures had been found that long-term high-fat diet treatment could increase the production of reactive oxygen, develop lipid peroxidation, oxidative injury [6,7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Curcuma kwangsiensis polysaccharides on blood lipid profiles and oxidative stress in high-fat rats

Zhong

Zhu

et al. 2009

International Journal of Biological Macromolecules

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“…In this sense, Zn and Cu for example, are required by superoxide dismutase for dismutation of superoxide anion to oxygen and hydrogen peroxide, while Fe is essential for enzymatic CAT activity 61,62 . Also, Se is a cofactor for glutathione peroxidase involved in the reduction of hydroperoxides in the cell 63,64 . Despite the functionality of these antioxidant enzymatic groups and the relevance of the minerals' co-factors balance, the caffeine in the experimental conditions evaluated in our investigation was not capable of influence these variables, corroborating with the maintenance of the activities of these respective antioxidant defense enzymes evaluated.…”

Section: Control Caf10 Caf50mentioning

confidence: 99%

Chronic caffeine use does not influence behavior and brain oxidative status in mice

Castro

Ladeira

Santos

et al. 2021

R. Assoc. bras. Nutr.

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Amplamente consumida nos alimentos e como suplemento alimentar, a cafeína tem sido estudada devido aos seus efeitos farmacológicos, principalmente no sistema nervoso central (SNC). O presente estudo investigou se o uso crônico da cafeína pode influenciar o estado oxidativo do cérebro e a atividade comportamental de camundongos fêmeas C57BL/6. Para isso, quinze animais foram randomizados nos seguintes grupos: Controle (solução salina à 0,9%), Caf10 (10 mg / kg de cafeína) e Caf50 (50 mg / kg de cafeína). Os animais receberam uma dose diária de cafeína por via i.p. durante 120 dias. Vinte e quatro horas após a última administração, os animais foram submetidos a testes comportamentais e foram eutanasiados. O sangue foi utilizado para análises bioquímicas. No cérebro, foi avaliado o estado oxidativo e os níveis de microminerais. A cafeína não influenciou os parâmetros antropométricos, perfil lipídico e níveis de proteína Creativa. Ademais, as atividades de superóxido dismutase (SOD) e glutationa-Stransferase (GST) mantiveram o mesmo perfil de resposta. Em contrapartida, a atividade da catalase (CAT) diminuiu em ambos os grupos que receberam cafeína. Já os níveis de malondialdeído e proteína carbonilada não se alteraram entre os grupos, assim como a distribuição dos microminerais. Nenhuma dose de cafeína desencadeou comportamento do tipo ansioso nos animais. Portanto, considerando o tempo de administração da cafeína, acreditamos que houve a adaptação celular desencadeada pelo seu uso, tendendo a um efeito protetor no cérebro. Além disso, o espaço amostral reduzido foi uma limitação para entendimentos mais acurados sobre os efeitos da cafeína no SNC. Palavras-chave: Cafeína. Espécies reativas de oxigênio. Comportamento Animal.

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High vitamin E and selenium elevate, whereas diphenyl-para-phenylenediamine plus caffeine lowers liver fat in alcohol-fed rats

Cited by 8 publications

References 19 publications

Influence of selenium and/or magnesium on alleviation alcohol induced oxidative stress in rats, normalization function of liver and changes in serum lipid parameters

Influence of selenium and/or magnesium on alleviation alcohol induced oxidative stress in rats, normalization function of liver and changes in serum lipid parameters

Effect of Curcuma kwangsiensis polysaccharides on blood lipid profiles and oxidative stress in high-fat rats

Chronic caffeine use does not influence behavior and brain oxidative status in mice

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