High-Voltage Electrical Injury

Zelt, Ronald G.; Daniel, Rollin K.; Ballard, Paul; Brissette, Yves; Héroux, Paul

doi:10.1097/00006534-198812000-00014

Cited by 77 publications

(19 citation statements)

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“…Perhaps the most critical factor of clinical relevance is the method used to induce burns in experimental animals. Techniques that have been used to generate burn surfaces in experimental animal models include direct contact with a heated metal [11],[61], electricity [62] and heated water [11]. In the direct contact method, the back of the animal is shaved and a heated metal is applied to the skin as many times as necessary to induce the desired burn surface area [11].…”

Section: Animal Models Of Burnsmentioning

confidence: 99%

“…The drawback of this method is the lack of a homogenous uniform burn depth. Electrical burn models are very complex to perform and usually require larger animals like monkeys to achieve lesions comparable to those observed in humans [62]. Among the aforementioned models, the hot water model has gained widespread use and is considered by some experts as the standard for animal models of burns.…”

Section: Animal Models Of Burnsmentioning

confidence: 99%

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Animal models in burn research

Abdullahi

Amini-Nik

Jeschke

2014

Cell. Mol. Life Sci.

355

281

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Burn injury is a severe form of trauma affecting more than two million people in North America each year. Burn trauma is not a single pathophysiological event but a devastating injury that causes structural and functional deficits in numerous organ systems. Due to its complexity and the involvement of multiple organs, in vitro experiments cannot capture this complexity nor address the pathophysiology. In the past two decades, a number of burn animal models have been developed to replicate the various aspects of burn injury; to elucidate the pathophysiology and explore potential treatment interventions. Understanding the advantages and limitations of these animal models is essential for the design and development of treatments that are clinically relevant to humans. This review paper aims to highlight the common animal models of burn injury in order to provide investigators with a better understanding of the benefits and limitations of these models for translational applications. While many animal models of burn exist, we limit our discussion to the skin healing of mouse, rat, and pig. Additionally, we briefly explain hypermetabolic characteristics of burn injury and the animal model utilized to study this phenomena. Finally, we discuss the economic costs associated with each of these models in order to guide decisions of choosing the appropriate animal model for burn research.

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Section: Animal Models Of Burnsmentioning

confidence: 99%

Section: Animal Models Of Burnsmentioning

confidence: 99%

Animal models in burn research

Abdullahi

Amini-Nik

Jeschke

2014

Cell. Mol. Life Sci.

355

281

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“…The advantage is not only an increase in flap size but also the primary thinning of the transplanted tissue. 8,14 Of course, flap alternatives such as perforator flaps should be mentioned as a possibility for defect coverage. However, the use of those flaps in such severe injuries could be restricted because of the need for solid vessels and a short operation time.…”

Section: Complicationsmentioning

confidence: 99%

Microvascular Reconstruction in Burn and Electrical Burn Injuries of the Severely Traumatized Upper Extremity

Sauerbier

Ofer

Germann

et al. 2007

Plastic and Reconstructive Surgery

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“…Several studies have called into question the concept of progressive tissue necrosis in burns which has, over the years, gained considerable acceptance amongst burn surgeons. These studies describe the clinical impression of progressive tissue necrosis as, in fact, being the result of inadequate initial explorations, inadequate fasciotomies, subjective observations of viability and debridement that devascularised surrounding muscle [20][21][22][23][24]. We ensured that thorough debridement was performed by excising non-bleeding tissue until a viable vascular bed was reached, taking extra care to ensure that we did not devascularise viable tissue.…”

Section: Discussionmentioning

confidence: 99%