High Voltage Nanosecond Pulse Generator based on Inductive Energy Storage With Adjustable Pulse Width

Ma, Jiuxin; Yu, Liang; Ren, Lvheng; Liao, Yixin; Dong, Shoulong; Yao, Chenguo

doi:10.1109/ichve53725.2022.9961737

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…In these cases, the traditional pulsed power generators with capacitive energy storage (CES) have great limitations because they are essentially voltage sources and their output current can be changed significantly by loads with different resistance. Pulsed current generators using inductive energy storage (IES) can satisfy this demand, and there have been many studies on inductive pulsed current generators [12][13][14][15]. When the current flowing through the inductor changes, counter electromotive force will be generated at both ends of the inductor to maintain the original current amplitude.…”

Section: Introductionmentioning

confidence: 99%

The Cascade of High-Voltage Pulsed Current Sources

Dong,

Chen,

Qiu

et al. 2024

Electronics

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Currently, pulsed adders are used as pulsed voltage sources maturely. However, their use as pulsed current sources is significantly limited due to circuit impedance and the characteristics of power devices. This paper presents a simple yet effective design for a pulsed current source, incorporating a solid-state Marx pulsed adder as the primary power source and an inductor for energy storage. In the pulsed current source, a Marx pulsed adder produces high voltage to charge the inductor. Then, the stored inductance energy is converted to generate current pulses on the load; the amplitude of the pulsed current is unaffected by the load impedance within a certain range. The pulsed current source can be designed as a standard module, and several modules can form a cascade system for producing current pulses with higher voltage. Finally, a pulsed current source was developed, which can produce adjustable current pulses with high voltage. The design principles, control methods and the effects of the distribution parameters are described. The feasibility of the cascade pulsed power system was validated in experiments. Nine modules were connected to generate pulses of current 10 A on a 15 kΩ resistor.

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Section: Introductionmentioning

confidence: 99%

The Cascade of High-Voltage Pulsed Current Sources

Dong,

Chen,

Qiu

et al. 2024

Electronics

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“…Nevertheless, different research groups have used custom-designed and custommanufactured pulse generators, resulting in varying pulse conditions [15][16][17][18][19][20][21][22][23][24][25][26]. This may Bioengineering 2023, 10, 1069 2 of 18 present a perplexing and challenging situation when comparing and interpreting results.…”

Section: Introductionmentioning

confidence: 99%

Ultra-Low Intensity Post-Pulse Affects Cellular Responses Caused by Nanosecond Pulsed Electric Fields

Asadipour,

Zhou,

et al. 2023

Bioengineering

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High-intensity nanosecond pulse electric fields (nsPEF) can preferentially induce various effects, most notably regulated cell death and tumor elimination. These effects have almost exclusively been shown to be associated with nsPEF waveforms defined by pulse duration, rise time, amplitude (electric field), and pulse number. Other factors, such as low-intensity post-pulse waveform, have been completely overlooked. In this study, we show that post-pulse waveforms can alter the cell responses produced by the primary pulse waveform and can even elicit unique cellular responses, despite the primary pulse waveform being nearly identical. We employed two commonly used pulse generator designs, namely the Blumlein line (BL) and the pulse forming line (PFL), both featuring nearly identical 100 ns pulse durations, to investigate various cellular effects. Although the primary pulse waveforms were nearly identical in electric field and frequency distribution, the post-pulses differed between the two designs. The BL’s post-pulse was relatively long-lasting (~50 µs) and had an opposite polarity to the main pulse, whereas the PFL’s post-pulse was much shorter (~2 µs) and had the same polarity as the main pulse. Both post-pulse amplitudes were less than 5% of the main pulse, but the different post-pulses caused distinctly different cellular responses. The thresholds for dissipation of the mitochondrial membrane potential, loss of viability, and increase in plasma membrane PI permeability all occurred at lower pulsing numbers for the PFL than the BL, while mitochondrial reactive oxygen species generation occurred at similar pulsing numbers for both pulser designs. The PFL decreased spare respiratory capacity (SRC), whereas the BL increased SRC. Only the PFL caused a biphasic effect on trans-plasma membrane electron transport (tPMET). These studies demonstrate, for the first time, that conditions resulting from low post-pulse intensity charging have a significant impact on cell responses and should be considered when comparing the results from similar pulse waveforms.

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