High voltage pulse generation

Petkovšek, Marko; Nastran, J.; Voncina, D.; Zajec, Peter; Miklavčič, Damijan; Serša, Gregor

doi:10.1049/el:20020476

Cited by 15 publications

(6 citation statements)

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“…These converters use a capacitor bank to store the energy plus an inverter to provide unipolar/bipolar output voltage. Several topologies have been applied, including Marx generators, single-stage voltage source inverters, or modular multi-level approaches [44,[89][90][91]. The main challenge when using this approach is to achieve very high output voltage, which may require the use of multi-level topologies and high-voltage power devices, as well as the appropriate design of the energy storage system.…”

Section: Idealmentioning

confidence: 99%

Industrial Electronics for Biomedicine: A New Cancer Treatment Using Electroporation

Lucía

Sarnago

García-Sánchez

et al. 2019

EEE Ind. Electron. Mag.

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Industrial electronics comprises a wide range of transversal and multidisciplinary technologies and applications that has been enabling human advance since the emerging of this scientific discipline in the XX century. Among the many present challenges, biomedical applications are one of the most challenging and rewarding ones due to the complexity and magnitude of the problems to be solved, and its inherent relation with the most important aspects in the human being hierarchy of needs: health and well-being.Cancer treatment has become a major goal for the whole humanity due to the ability of this disease to affect in its many forms to all social collectives, despite age, gender or class, and its terrible consequences not only for the patient but also for the caregiver and close persons. Despite the many advances in the last decades, we are still in need of new and effective tools to prevent, treat, cure and palliate the effects of cancer in our society. In this context, electroporation has become a promising tool to fight against cancer which is based on applying short electric field pulses to the tissue to be treated to obtain the desired biological effects. Industrial electronics has and will have a significant impact in the research and clinical application of this technology by providing the required power electronic converters, control architectures, electromagnetic analysis and design, and measurement systems in a multidisciplinary context. This paper aims to present the current state-of-the-art and future challenges of electroporation as a promising cancer treatment tool, where industrial electronics is called to play a key role. Firstly, industrial electronics applications in medicine and, specifically, pulsed power applications, are discussed. After that, the current status of cancer treatment and the fundamentals, historic evolution and biomedical applications of electroporation are reviewed, making special emphasis in the multidisciplinary approach required. After that, the different technologies to implement high-voltage generators are discussed, future perspectives are drawn and different applications with experimental evidence are presented. This paper concludes evidencing the importance of industrial electronics in electroporation-based cancer treatment, opening a new window for improved cancer treatments.

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Section: Idealmentioning

confidence: 99%

Industrial Electronics for Biomedicine: A New Cancer Treatment Using Electroporation

Lucía

Sarnago

García-Sánchez

et al. 2019

EEE Ind. Electron. Mag.

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“…However, if capacitor C is replaced by pulse forming network and spark gap is used for the switch S the output amplitudes can reach several kV and a few kA. Modular square wave pulse generator was designed to improve output amplitude flexibility of the square wave pulse generator [37,38]. It consists of several square wave pulse generators connected in series (Fig.…”

Section: Square Wave Pulse Generatorsmentioning

confidence: 99%

Advantages and Disadvantages of Different Concepts of Electroporation Pulse Generation

Reberšek

Miklavčič

2011

Automatika

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Review Electroporator is a generator of electric pulses that is used for permeabilization of cells. There are five major concepts of electroporation design. Capacitor discharge, square wave generator, and analog generator are used to generate classical electroporation pulses that are longer than microsecond and pulse forming network, and resonant charging generator that are used to generate nanosecond electroporation pulses. The choice of an electroporator design is always driven by the biotechnological or biomedical application. Electroporators can be used for introduction of small (electrochemotherapy) and large molecules (gene electrotransfer), cell fusion, insertion of proteins into cell membrane, electroporation of organelles, pasteurization, tissue ablation etc. Basic concepts and foreseeable future developments in electroporator design are presented in this article.

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“…The voltage of the individual source is constant and can participate in a generation of a common output pulse at any time. With an appropriate control of output transistors Q 1 -Q N that operate as switches and connect the modules in series, a total of 2 N different output voltage levels with the resolution of V 1 are obtained [48]. Although the design of each individual source is similar to the design of previously described square wave pulse generator, the individual source used in this concept has no problems with the shortage of power.…”

Section: Modular High Voltage Sourcementioning

confidence: 99%

“…Operation of the device is based on a principle of digital-to-analogue converter, thus the device comprises several (N) individually controlled electrically isolated DC voltage modules, where the amplitude of the particular voltage source V N is twice as high as in the preceding module. With an appropriate control of output transistors Q 1 -Q N the modules are connected in series and a total of 2 N different output voltage levels with the resolution of V 1 are obtained[48].…”

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confidence: 99%