High VWF, low ADAMTS13 puts women at risk

Bender, Markus

doi:10.1182/blood-2011-12-395889

Cited by 3 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the physiological implications of elevated vWF levels (increasing up to 400% of the normal level in various conditions [190,191]) require additional investigation, it is currently believed that plasma vWF level is a surrogate marker of increased risk of vascular complications in septic patients and in those with vascular disease, which makes vWF antagonism a promising therapeutic target in thrombosis and inflammation.…”

Section: Vwf-related Antithrombotic Treatment Strategiesmentioning

confidence: 99%

Endothelial Cell von Willebrand Factor Secretion in Health and Cardiovascular Disease

Rusu¹,

Minshall²

2018

Endothelial Dysfunction - Old Concepts and New Challenges

View full text Add to dashboard Cite

The main function of von Willebrand factor (vWF) is to initiate platelet adhesion upon vascular injury. The hallmark of acute and chronical inflammation is the widespread activation of endothelial cells which provokes excessive vWF secretion from the endothelial cell storage pool. The level of vWF in blood not only reflects the state of endothelial activation early on in the pathogenesis, but also predicts disease outcome. Elevation in the blood level of vWF occurs either by pathologic increase in the rate of basal vWF secretion or by increased evoked vWF release from dysfunctional/activated endothelial cells (ECs). The increase in plasma vWF is predictive of prothrombotic complications and multi-organ system failure associated with reduced survival in the context of severe inflammatory response syndrome, type II diabetes mellitus, stroke and other inflammatory cardiovascular disease states. This chapter focuses on the role of high circulating vWF levels in thrombotic and inflammatory disease while paying attention to the emerging vWFrelated drug development strategies.

show abstract

Section: Vwf-related Antithrombotic Treatment Strategiesmentioning

confidence: 99%