1996
DOI: 10.1016/0168-3659(95)00118-2
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High water content BSA-PEG hydrogel for controlled release device: Evaluation of the drug release properties

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Cited by 93 publications
(59 citation statements)
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“…Gayet and Fortier calculated the diffusion coefficient of drugs, having different molecular weight, in BSA-PEG hydrogel. 28 The value of D was found to decrease gradually from 15. The exceptionally slow diffusion of BSA and relatively fast diffusion of water may partially be due to the difference in the respective path of transport.…”
Section: In Vitro Bsa Releasementioning
confidence: 94%
“…Gayet and Fortier calculated the diffusion coefficient of drugs, having different molecular weight, in BSA-PEG hydrogel. 28 The value of D was found to decrease gradually from 15. The exceptionally slow diffusion of BSA and relatively fast diffusion of water may partially be due to the difference in the respective path of transport.…”
Section: In Vitro Bsa Releasementioning
confidence: 94%
“…Subsequently, other proteins have also been PEGylated in order to prolong their residence time in the blood stream by improving their physical and thermal stability, increasing their protection against proteolysis and decreasing their clearance from the body [9,10]. PEGylated albumin hydrogels for drug delivery applications have also recently been described by two groups [11][12][13], however, in these studies the drug release rates from the hydrogels were dominated by Fickian diffusion and not controlled by the specific affinity of the various tested drugs for the albumin constituent.…”
Section: Introductionmentioning
confidence: 99%
“…However, a downside of biopolymers is their batch-to-batch variation [62][63][64], entailing variation of the physical properties of gels that are formed from them. To avoid this problem, synthetic polymers like polyethylene glycol [65][66][67], polyhydroxyethylmethacrylate [68][69][70], and polyglycerol [71][72][73] can be used to substitute biopolymers. In their native form, these polymers are incapable of forming hydrogels.…”
Section: Introductionmentioning
confidence: 99%