High-yielding aqueous synthesis of chloroacetophenones and aroyl chlorohydrins

Zhang, Xixi; Liu, Lei; Li, Chunbao

doi:10.1039/c6ra00433d

Cited by 6 publications

(2 citation statements)

References 61 publications

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“…An alternative substitution procedure, developed by Zhang and co-workers, generated 14 α-chloroketones in quantitative yields from α-bromoketones ( Scheme 80 ) [ 207 ]. This route tolerated the presence of electron-donating and -withdrawing aromatic substituents.…”

Section: Miscellaneous Routesmentioning

confidence: 99%

Synthetic Access to Aromatic α-Haloketones

et al. 2022

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α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.

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Section: Miscellaneous Routesmentioning

confidence: 99%

Synthetic Access to Aromatic α-Haloketones

et al. 2022

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“…However, chemical reactions are a very complex process, and the use of large amounts of organic solvents can cause environmental problems. [31][32][33][34][35][36][37] The introduction of the concept of green chemistry requires chemists and environmentalists to reduce the use of toxic and hazardous chemical reagents or to find new green alternatives to these materials. In addition, many chemical reagents are toxic, flammable, and explosive, posing major safety issues.…”

Section: Introductionmentioning

confidence: 99%

An efficient catalytic and solvent‐free method for the synthesis of mono‐organofunctionalized polymethylhydrosiloxane derivatives

Gui

Dong

et al. 2023

Polymers for Advanced Techs

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Synthetic reactions with distinctive physicochemical properties and the study of functional groups during synthesis provide an effective way to design polymers on an individual basis. The functionalization of polymethylhydrosiloxane (PMHS) has been performed via hydrosilylation of PMHS with selected alkenes with different active functional groups. In the reaction of PMHS with selected CC bond‐containing olefins in solvent‐free systems, the most efficient catalyst system can be selected to obtain the PMHS reagents to introduce the desired functional groups while generating only regional isomeric products. On‐line real‐time monitoring techniques, in situ Fourier‐transform infrared (FT‐IR), were utilized to determine the chemical reaction rates and reaction conversions for each chemical reaction, and to assess the merits of the reaction systems. In addition, the structures of the functionalized polymers were characterized using FT‐IR spectroscopy, nuclear magnetic resonance (NMR), and gel permeation chromatography (GPC). The kinetic parameters of typical chemical reaction processes were calculated using Kissinger's equation and Ozawa's equation. The comparisons between solvent and solvent‐free systems were carried out under the same conditions, and the statistics revealed that the solvent‐free system was more efficient than its solvent‐based counterpart. This research on the introduction of monofunctional groups into PMHS side chains might pave the way for a variety of diverse functional groups, thus allowing for the further application of PMHS and its derivatives.

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CV‐driven Optimization: Cobalt‐Catalyzed Electrochemical Expedient Oxychlorination of Alkenes via ORR

Tian

Jia

et al. 2019

Adv Synth Catal

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Instead of screening reaction conditions by yield-based chemical trial-and-error, potential-based cyclic voltammetry was alternatively employed for optimization of electrochemical oxychlorination of alkenes. With this unconventional screening method, the catalyst system including catalysts, molar ratio of chloride sources and solvents were identified in a rational, time-and energy-efficient manner. The optimal catalytic system in combination with oxygen reduction reaction enabled broad substrate scopes for the desired transformation by taking advantages of persistent radical effect. UV-vis and CV titration experiments confirmed the in-situ formed catalytic species [CoCl 5 ]. Moreover, cyclic voltammetry was applied to obtain mechanistic insights in our reaction system.

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High-yielding aqueous synthesis of chloroacetophenones and aroyl chlorohydrins

Abstract: Two new reactions for preparing chloroacetophenones and aroyl chlorohydrins promoted by sulfonyl chloride and mediated by water are reported.

Cited by 6 publications

References 61 publications

Synthetic Access to Aromatic α-Haloketones

Synthetic Access to Aromatic α-Haloketones

An efficient catalytic and solvent‐free method for the synthesis of mono‐organofunctionalized polymethylhydrosiloxane derivatives

CV‐driven Optimization: Cobalt‐Catalyzed Electrochemical Expedient Oxychlorination of Alkenes via ORR

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