Higher acyclic nitrogen containing deoxy sugar derivatives: A new lead in the generation of antimycobacterial chemotherapeutics

C-3 Alkyl/Arylalkyl-2,3-dideoxy Hex-2-enopyranosides as Antitubercular Agents: Synthesis, Biological Evaluation, and QSAR Study

“…However, many of these drugs have different disadvantages such as prolonged treatment schedules, host toxicity, ineffectiveness against resistant strains, etc. This has motivated the search for new chemical prototypes capable of rapid mycobactericidal action with shortened duration of therapy, reduced toxicity, and enhanced activity against drug resistant strains and also against the latent bacteria for its control. − This paradigm shift in the strategies has drawn attention toward the outer cell wall and membranes of the pathogen as an attractive target for exploring new drugs. , In mycobacteria, the cell wall structure consists of a dense network of cross-linked sugar residues esterified with mycolic acid at the ends. , This understanding has prompted the investigation of various sugar prototypes with distinct characteristics as potential antitubercular agents. − Earlier, we investigated some highly functionalized heptenol and octenol derivatives from glucal and galactal for their antitubercular activity. , A quantitative structure−activity relationship (QSAR) study of these analogues with topological descriptors has suggested less branched and saturated structural templates for improved activity . In recent literature, some 2 H -pyran-3(6 H )-one derivatives (Figure ) are reported to exhibit significant activity against Gram-positive bacteria .…”

“…[17][18][19][20][21] Earlier, we investigated some highly functionalized heptenol and octenol derivatives from glucal and galactal for their antitubercular activity. 22,23 A quantitative structure-activity relationship (QSAR) study of these analogues with topological descriptors has suggested less branched and saturated structural templates for improved activity. 24 In recent literature, some 2H-pyran-3(6H)one derivatives (Figure 1) are reported to exhibit significant activity against Gram-positive bacteria.…”