Higher augmentation index is associated with tension‐type headache and migraine in middle‐aged/older humans with obesity

Kalil, Graziela Z; Recober, Ana; Hoang-Tienor, Ann; Zimmerman, M. Bridget; Haynes, William G.; Pierce, Gary L.

doi:10.1002/oby.21414

Cited by 8 publications

(7 citation statements)

References 42 publications

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“…This analysis uses baseline data from a clinical trial of pharmacotherapy for weight loss (http://ClinicalTrials.gov identifier NCT01351753) . Persons age 40 to 75 with a BMI ≥30 kg/m 2 and at least one additional risk factor for CVD (e.g., diabetes mellitus, elevated fasting glucose, hyperlipidemia, hypertension, metabolic syndrome) were eligible.…”

Section: Methodsmentioning

confidence: 99%

“…Persons age 40 to 75 with a BMI ≥30 kg/m 2 and at least one additional risk factor for CVD (e.g., diabetes mellitus, elevated fasting glucose, hyperlipidemia, hypertension, metabolic syndrome) were eligible. Exclusion criteria have been described in detail elsewhere . Participants provided written informed consent as part of a University of Iowa Institutional Review Board‐approved protocol.…”

Section: Methodsmentioning

confidence: 99%

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Anxiety independently contributes to elevated inflammation in humans with obesity

Pierce

Kalil

Ajibewa

et al. 2016

Obesity

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Objective Anxious and depressive states are associated with increased cardiovascular disease (CVD) risk and a proinflammatory phenotype, although the latter appears to be at least partially explained by adiposity. We hypothesized that depression and anxiety would be associated with elevated inflammation independent of adiposity in persons with obesity at high risk of CVD. Methods We explored the relation between baseline anxiety as measured by the Beck Anxiety Inventory (BAI) and depression as measured by the Beck Depression Inventory-II (BDI-II), and baseline serum c-reactive protein (CRP) in a cross-sectional sample of 100 participants [mean (SD) age 57.8 (7.7) years; 64% female] with obesity [mean (SD) body mass index, BMI 37.3 (5.5) kg/m2] enrolled in a clinical trial for pharmacological weight loss interventions. Results BAI, but not BDI-II, scores were significantly correlated with CRP (rho=0.28, p=0.005). BMI was also highly correlated with CRP (rho=0.42, p<0.0001). In multivariate models, the relation between anxiety and CRP remained significant (p=0.038), independent of BMI, age and sex. Conclusion Anxiety, but not depression, is associated with elevated inflammation in persons with obesity beyond that attributable to higher BMI. Further study is warranted to assess whether anxiety represents a potential therapeutic target to mitigate corresponding CVD risk associated with elevated inflammation in persons with obesity.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Anxiety independently contributes to elevated inflammation in humans with obesity

Pierce

Kalil

Ajibewa

et al. 2016

Obesity

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“…For example, higher AIx has been associated with increased cardiovascular risk (18,19), lower cardiorespiratory fitness (20), and increased clinical severity of coronary artery disease and percutaneous coronary intervention treatment in patients with a high Framingham risk score (18). In addition, higher AIx has also been associated with normotensive kidney disease (21), headaches and migraines in obese participants (22), and lower academic and motor performance in adolescents (23).…”

Section: Introductionmentioning

confidence: 99%

Inter-operator Reliability for Measuring Pulse Wave Velocity and Augmentation Index

Elliot

Hamlin

Lizamore

2020

Front. Cardiovasc. Med.

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Background: Arterial stiffness is a reversible precursor to hypertension. However, research is needed to determine the minimum amount of training required before acceptable arterial stiffness measurements are collected by novice operators. Objective: To compare novice vs. experienced operator measurements over a 2-week training period to assess when expert-like measures are achieved by the novice operator. Method: Forty-one participants (18 males, 23 females, age: 46.6 ± 14.9 years; BMI: 25.2 ± 3.8; systolic blood pressure: 122.8 ± 14.7 mmHg) received alternating novice and experienced operator arterial stiffness assessments. Measurements included: pulse wave velocity (PWV; using the automatic-capture time-periods of 5-, 10-, and 20-s) and augmentation index (AIx75) measurements using the SphygmoCor XCEL System v1 (AtCor Medical Pty Ltd., Sydney, Australia). Data were chronologically arranged into quintiles. Results: The intraclass correlation coefficient for PWV substantially improved from quintile 1 (r < 0.8) to quintile 2 and beyond (typically r > 0.8) while AIx75 improved consistently (r = 0.7 in quintile 1 and r = 0.97 in quintile 5). The coefficient of variation was lowest in quintile 4 (PWV: 4.7-6% across the three measurement time-periods; and 15% for AIx75) but increased in quintile 5 (PWV: 6.2-10.5%; and 25% for AIx75). All measurements demonstrated acceptable to excellent reliability after quintile 2. Conclusion: To achieve expert-like PWV measurements in this study, the novice operator underwent a familiarization session including guided practice measurements on 5 different people, for 10-15 min per person on two occasions (∼2.5 h). The novice operator then required ≥14 practice measurements, with accuracy continuing to improve up to 30 participants. At least 30 training measurements are recommended for novices to take acceptable AIx75 measurements after a familiarization training.

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“…Carotid-femoral pulse wave velocity (CFPWV) is the gold standard non-invasive test to measure aortic stiffness 27 . In one study, 93 middle-aged/elderly obese adult subjects with at least one additional cardiovascular risk factor were grouped according to no headache, tension-type headache (TTH) or migraine and AI and carotid-femoral pulse wave velocity were measured as an indicator of aortic stiffness 28 . It was found that elevated AI was independently associated with the presence of either migraine or TTH, but could not discriminate between migraine and TTH.…”

Section: Discussionmentioning

confidence: 99%

Premenapozal migren hastalarında aort sertliği parametrelerinin değerlendirilmesi

Güntürk

Dogan

Topuz

2020

Cukurova Medical Journal

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Öz Purpose: Migraine is an episodic primary headache disorder, which affects approximately 10% of the adult population, predominantly females. Based on the changes detected in migraine and previous findings, arterial stiffness can be considered to be an important contributor to vascular events in patients with migraine. The aim of this study was to investigate the associations between atherosclerosis and migraine through the evaluation of aortic stiffness in premenopausal migraine patients. Materials and Methods: The study included 68 female patients with migraine, and a control group of 39 healthy females. To reveal the association between migraine and arterial stiffness, echocardiography was applied and aortic stiffness was evaluated. Blood pressure measurements, basic biochemical tests and the 12 derivation-ECG recordings of each patient were taken simultaneously. Results: Basic echocardiographic findings were similar in patients and the control group. Systolic and diastolic diameters of the aorta, and the change in aortic diameter were also similar in both groups. Aortic distensibility, aortic strain and beta indices were also similar in both groups. No significant differences were determined between patients with and without aura migraine and the control group in respect of systolic blood pressure, diastolic blood pressure and pulse pressure. Conclusion: As a marker of atherosclerosis, the aortic stiffness parameters didn't differ between migraine and control group.

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Higher augmentation index is associated with tension‐type headache and migraine in middle‐aged/older humans with obesity

Cited by 8 publications

References 42 publications

Anxiety independently contributes to elevated inflammation in humans with obesity

Anxiety independently contributes to elevated inflammation in humans with obesity

Inter-operator Reliability for Measuring Pulse Wave Velocity and Augmentation Index

Premenapozal migren hastalarında aort sertliği parametrelerinin değerlendirilmesi

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