Higher baseline dietary fat and fatty acid intake is associated with increased risk of incident prostate cancer in the SABOR study

Abstract

Background-To study the association of nutrient intake measured by baseline food frequency questionnaire and risk of subsequent prostate cancer (PCa) in the SABOR (San Antonio Biomarkers of Risk) cohort study. Methods-After IRB approval, more than 1903 men enrolled in a prospective cohort from 2000 to 2010 as part of the SABOR clinical validation site for the National Cancer Institute Early Detection Research Network. Food and nutrient intakes were calculated using a Food Frequency Questionnaire. Cox proportional hazards modeling and covariate-balanced propensity scores were used to assess the associations between all nutrients and PCa. Results-A total of 229 men were diagnosed with PCa by prostate biopsy. Among all nutrients, increased risk of PCa was associated with intake of dietary fat scaled by the total caloric intake, particularly saturated fatty acid (SFA) [HR 1.19; 95% CI, 1.07-1.32), P value <0.001, False discovery rate (FDR) 0.047] and trans fatty acid (TFA) [HR per quintile 1.21; (95% CI) (1.08-Michael A. Liss

The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?

“…This consideration, moreover, is valid also for androgen axis-targeted therapy in PCa treatment, which is influenced in its clinical response and antitumoral efficiency by gut microbiota. Conversely, androgen axis-targeted therapy enhances Bacteroides and Streptococci rates in the gastrointestinal tract while lowering overall bacterial diversity [108]. Besides, an analysis of the fecal microbiota of healthy volunteers and PCa patients by 16S rDNAsequencing, showed a greater abundance of Akkermansia muciniphila and Ruminococcaceae spp.…”

Influence of Diet and Nutrition on Prostate Cancer

“…Numerous cohort and case-control studies report that increased dietary fat intake is associated with PCa risk [17][18][19][20], although other studies showed no association [21][22][23][24]. Additionally, the relationship between total fat consumption and PCa is controversial.…”

“…Additionally, the relationship between total fat consumption and PCa is controversial. A population-based case-control study of 1,300 men aged <60 years in the United Kingdom reported that the risk of PCa increased among those with higher lipid intake as compared with those with lower lipid intake (OR = 2.53, 95% CI = 1.72-3.74) [20]. By contrast, basic research studies repeatedly show that fat consumption induces PCa growth, with several mechanisms identified as promoters of PCa development and progression in subjects fed a high-fat diet (HFD).…”

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

“…On the other hand, a decrease in the fatty acid content of the peri-prostatic adipose tissue has been observed with PCa aggressiveness [ 193 ]. Nevertheless, despite the ample research conducted on the subject, a salient explanation of the effect of FA intake on PCa is yet expected [ 194 , 195 ]. Aucoin et al conducted a systematic review examining the effects of marine fatty acid supplementation, in particular, on serum PSA concentrations and PCa risk [ 23 ].…”