Higher Basidiomycota as a Source of Antitumor and Immunostimulating Polysaccharides (Review)

Reshetnikov, Sergey V.; Tan, Kok Kheng

doi:10.1615/intjmedmushr.v3.i4.80

Cited by 104 publications

(84 citation statements)

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“…Some polysaccharides or polysaccharide-protein complexes from mushrooms are able to stimulate the non-specific immune system and to exert antitumor activity through the stimulation of the host's defence mechanism (Chihara et al, 1969;Wasser & Weis, 1999;Reshetnikov et al, 2001). These drugs activate effector cells like macrophages, T lymphocytes and NK cells to secrete cytokines like TNF-a, IFN-g, IL-1b, etc., which are antiproliferative and induce apoptosis and differentiation in tumor cells (Wasser & Weis, 1999;Reshetnikov et al, 2001). There is evidence that β-d-glucans induce a biological response by binding to membrane complement receptor type 3 (CR3, alphaMb2 integrin or CD11b/CD18) on immune effector cells.…”

Section: Mushrooms As Immunomodulatorsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

124

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Abstract:Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.

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Section: Mushrooms As Immunomodulatorsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

124

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show abstract

“…Fungi, like yeast, algae, bacteria and higher plants have been intensively investigated for antitumour modality, because it appears that they are able to modulate the body's immune responses against tumours with very low toxic potential (Oh et al, 1992;Song et al, 1995;Borchers et al, 1999;Han et al, 1999). Studies indicate that the main components in these basidiomycetes are polysaccharides (Lorenzen and Anke, 1998;Reshetnikov et al, 2001;Wasser, 2002). Beta-glucocans isolated from lentinan (Lentinus edodes), pachymaran (Poria cocos), schizophyllan (Schizophyllum commune) and krestin (Coriolus versicolor) have been demonstrated to stimulate lymphocytes and elicit nonspecific immune-activities in various experimental settings (Wasser, 2002).…”

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confidence: 99%

Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer

et al. 2006

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It has been demonstrated that the Phellinus linteus (PL) mushroom, which mainly consists of polysaccharides, possesses antitumour activity. The mechanisms of PL against malignant growth remain unknown. The anticancer drug doxorubicin (Dox) has been shown to induce apoptosis via initiating a caspase cascade. In this investigation, we tested the effect of PL on Dox-induced apoptosis in prostate cancer LNCaP cells. We showed that PL or Dox, at relatively low doses, does not induce apoptosis in the cells. However, combination treatment with low doses of PL and Dox results in a synergistic effect on the induction of apoptosis. In this apoptotic process, caspases 8, 3 and BID are cleaved, and the addition of caspase inhibitor z-VADfmk completely blocks apoptosis. In addition, JNK is activated in response to PL or the combination treatment in LNCaP cells. The suppression of JNK partially inhibits the induction of apoptosis elicited by the co-treatment. These findings indicate that PL has a synergistic effect with Dox to activate caspases in prostate cancer LNCaP cells. Our study also suggests that PL has therapeutic potential to augment the magnitude of apoptosis induced by antiprostate cancer drugs.

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“…The structure and pharmacological effect(s) of polysaccharides produced by G. lucidum is being actively studied (13,20,21). The potential role of G. lucidum polysaccharide in tumor therapy and the possible mechanisms involved were examined (22).…”

Section: Discussionmentioning

confidence: 99%

“…A liquid culture medium with 1.0 g. 20.0 (pH 6.0) was prepared in preliminary studies. This medium was reported to be ideal for exopolysaccharides (EPS) production by basidiomycetes (16).…”

Section: Screening For Exopolysaccharide and Endopolysaccharidementioning

confidence: 99%

Screening of Mushrooms for Polysaccharides

Rajaratnam

Vinuthna

2014

Iran J Biotech

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Background: Mushrooms have been valued as high tasty nutritional and nutraceutical food throughout the world. At present 270 species of mushrooms are known to have various nutritional and therapeutic properties. Polysaccharides are the primary content of mushrooms that are used for their pharmaceutical properties as immunostimulators. Objectives: Here, Mushrooms were screened for useful polysaccharides. Materials and Methods: Fungal fruiting bodies were collected in rainy season, isolated and maintained in malt agar medium, and screened for their endo-and exo-polysaccharides. Results:The mushrooms screened in this study are good producers of exopolysaccharides (EPS) and intracellular polysaccharides (IPS). Ganoderma lucidum was the best producer of polysaccharide among all the isolates. Discussions: Mushroom polysaccharides are well known for their antidiabetic, antitumor and hepatoprotective activities, and so are likely to be used in the preparation of novel drugs. It is suggested that a thorough study on the optimization and characterization of these polysaccharides and biomolecules is essential to exploit this mushroom on an industrial scale.

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Higher Basidiomycota as a Source of Antitumor and Immunostimulating Polysaccharides (Review)

Cited by 104 publications

References 0 publications

Mushrooms as therapeutic agents

Mushrooms as therapeutic agents

Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer

Screening of Mushrooms for Polysaccharides

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