Higher Biomarker-Calibrated Protein Intake Is Not Associated with Impaired Renal Function in Postmenopausal Women,

Beasley, Jeannette M.; Aragaki, Aaron K.; LaCroix, Andrea Z.; Neuhouser, Marian L.; Tinker, Lesley F.; Cauley, Jane A.; Ensrud, Kristine E.; Jackson, Rebecca D.; Prentice, Ross L.

doi:10.3945/jn.110.135814

Cited by 24 publications

(24 citation statements)

References 37 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(52) In an older study using data from two nested case-control studies of postmenopausal women within the Women’s Health Initiative Observational Study, biomarker-calibrated protein intake was not associated with odds of impaired renal function. (53) In addition, in a 6.4-y of follow-up in the Cardiovascular Health Study of older adults, neither total, animal, or plant protein intake were associated with eGFR. (54) Many of these studies used cystatin-C-based estimates of eGFR, whereas we used a creatinine-based equation given available data.…”

Section: Discussionmentioning

confidence: 99%

Dietary protein and changes in markers of cardiometabolic health across 20 years of follow-up in middle-aged Americans

Hruby

Jacques

2018

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Dietary protein plays a role in counteracting age-related muscle loss. However, limited long-term data exist on protein intake and markers of cardiometabolic health, which tend to deteriorate with age. Design: Prospective cohort study. Food frequency questionnaire-derived protein intake (g/d) and cardiometabolic markers were assessed up to five times across 20 years. Markers included systolic (SBP) and diastolic blood pressures (DBP), circulating lipids (total, HDL, LDL cholesterol; triglycerides), estimated glomerular filtration rate (eGFR), fasting glucose (FG), weight, and waist circumference (WC). Mixed models accounting for repeated measures were used to estimate adjusted mean annualized changes in outcomes per quartile category of protein. Setting: Framingham Heart Study Offspring cohort, USA Subjects: 3,066 participants with 12,333 unique observations, baseline age [mean (SD)]: 54.0 (9.7) y, BMI: 27.4 (4.9) kg/m2, 53.5% female Results: In fully adjusted models, there were favorable associations (mean (SE)) of total protein with annualized changes in SBP (lowest vs. highest intake: 0.34 [0.06] vs. 0.04 [0.06] mmHg, P trend=0.001) and eGFR (−1.03 [0.06] vs. −0.87 [0.05] mL/min/1.73 m2, P trend=0.046), unfavorable associations with changes in FG (0.013 [0.004] vs. 0.028 [0.004] mmol/L, P trend=0.004), and no associations with weight, WC, DBP, or lipids. Animal protein was favorably associated with SBP and unfavorably with FG and WC; plant protein was favorably associated with FG and WC. Conclusions: The present study provides evidence that protein intake may influence changes in cardiometabolic health independent of change in weight in healthy adults and that protein’s role in cardiometabolic health may depend on the protein source.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary protein and changes in markers of cardiometabolic health across 20 years of follow-up in middle-aged Americans

Hruby

Jacques

2018

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…However, evidence shows that many healthy older adults have preserved kidney function. (79–81) On the other hand, those older adults who are unhealthy are more likely to develop mild kidney insufficiency or CKD. For such individuals with a short life expectancy, nutritional recommendations (such as restriction of dietary protein intake) should support quality of life in the short-term.…”

Section: Concerns About Negative Effects Of Higher Protein Intake In mentioning

confidence: 99%

Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group

et al. 2014

View full text Add to dashboard Cite

The aging process is associated with gradual and progressive loss of muscle mass along with lowered strength and physical endurance. This condition, sarcopenia, has been widely observed with aging in sedentary adults. Regular aerobic and resistance exercise programs have been shown to counteract most aspects of sarcopenia. In addition, good nutrition, especially adequate protein and energy intake, can help limit and treat age-related declines in muscle mass, strength, and functional abilities. Protein nutrition in combination with exercise is considered optimal for maintaining muscle function. With the goal of providing recommendations for health care professionals to help older adults sustain muscle strength and function into older age, the European Society for Clinical Nutrition and Metabolism (ESPEN) hosted a Workshop on Protein Requirements in the Elderly, held in Dubrovnik on November 24 and 25, 2013. Based on the evidence presented and discussed, the following recommendations are made: (1) for healthy older people, the diet should provide at least 1.0 to 1.2 g protein/kg body weight/day (2) for older people who are malnourished or at risk of malnutrition because they have acute or chronic illness, the diet should provide 1.2 to 1.5 g protein/kg body weight/day, with even higher intake for individuals with severe illness or injury, and (3) daily physical activity or exercise (resistance training, aerobic exercise) should be undertaken by all older people, for as long as possible.

show abstract

“…Those with normal renal function had no such decline. Recent work on an aging population (68) , where renal function tends to decline (as indicated by reduced glomerular filtration rate), has investigated whether dietary protein is associated with impaired renal function. Data from two nested case-control studies within the Women's Health Initiative Observational Study (n 2419) were examined.…”

Section: Potential Side Effects Of High-protein Weight Loss Dietsmentioning

confidence: 99%

Safety and efficacy of high-protein diets for weight loss

Johnstone

2012

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Dietary strategies that can help reduce hunger and promote fullness are beneficial for weight control, since these are major limiting factors for success. High-protein (HP) diets, specifically those that maintain the absolute number of grams ingested, while reducing energy, are a popular strategy for weight loss (WL) due to the effects of protein-induced satiety to control hunger. Nonetheless, both the safety and efficacy of HP WL diets have been questioned, particularly in combination with low-carbohydrate advice. Nonetheless, for short-to-medium-term intervention studies (over several months), increasing the energetic contribution of protein does appear effective. The effects of HP diets on appetite, bone health, renal function, blood pressure, cardiovascular bio-markers, antioxidant status, gut health and psychological function are discussed. Further research is warranted to validate the physiological effects of HP diets over longer periods of time, including studies that modify the quality of macronutrients (i.e. the type of carbohydrate, fat and protein) and the interaction with other interventions (e.g. exercise and dietary supplements). What is a high-protein diet?An important factor to consider is the definition of a 'highprotein (HP) diet', as there are several ways to consider the protein content of a diet. The composition of the diet can be determined as the absolute amount of the protein (grams), the % of total energy as protein or the amount of protein ingested per kg body weight. Normal protein intake in the UK is approximately 16% of energy intake(1) for a sedentary adult, which is approximately 64-88 g/d at energy balance for females and males, respectively. There is no general consensus as to what a 'high'-protein diet is: the food industry use the term 'protein-enriched' for 20 % protein from energy. The HP diets reported for weight loss (WL) studies often include 30% of energy intake as protein. There are many variants such as the Zone diet (2) and the CSIRO diet (3) . In general, protein as a percentage of energy is doubled from 15 to 30%. Note, this does not mean that absolute protein intake (g) is doubled, as energy intake is reduced, with only a 20 % increase in the actual amount (g) of protein. The guidelines from the Institute of Medicine allow for the inclusion of higher amounts of protein than previously recommended in a healthy diet (4) . This Institute concluded that there is no clear evidence that an HP intake increases the risk of renal stones, osteoporosis, cancer or CVD. Thus, the acceptable protein distribution for maintenance requirements was set to 5-20% of energy for children aged 1-3 years, 10-30 % for children aged 3-18 years and 10-35 % for adults. It is not clear as to how much protein is required to maximise proteininduced satiety for energy restriction and WL or whether there is a relationship with the energy density of the diet.Both the safety (5) and efficacy (5) of HP WL diets have been questioned, particularly in combination with low-carbohydrate advice (6) . Low-ca...

show abstract

Higher Biomarker-Calibrated Protein Intake Is Not Associated with Impaired Renal Function in Postmenopausal Women,

Cited by 24 publications

References 37 publications

Dietary protein and changes in markers of cardiometabolic health across 20 years of follow-up in middle-aged Americans

Dietary protein and changes in markers of cardiometabolic health across 20 years of follow-up in middle-aged Americans

Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group

Safety and efficacy of high-protein diets for weight loss

Contact Info

Product

Resources

About