Higher circulating levels of chemokines CXCL10, CCL20 and CCL22 in patients with ischemic heart disease

Safa, Amin; Rashidinejad, Hamidreza; Khalili, Maryam; Dabiri, Shahriar; Nemati, Maryam; Mohammadi, Mohammad Mahdi; Jafarzadeh, Abdollah

doi:10.1016/j.cyto.2016.04.006

Cited by 50 publications

(41 citation statements)

References 47 publications

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“…CXCL10 was also elevated in acute myocardial infarction, measured 3–5 days after admission. The study also confirmed the correlation of tradition risk factor with CXCL10, as mean serum levels of CXCL10 in patients with hypertension, dyslipidemia, obesity, diabetes and smoking were significantly higher as compared to the control group (51). …”

Section: Clinical Experience With Cxcr3 Binding Chemokines In Ischemisupporting

confidence: 73%

“…Safa et al (51) in a larger study in 260 patients and 100 healthy controls managed to capture elevated CXCL10 levels in patients with unstable angina. In this study the serum levels of CXCL10 were measured at the time of admission and were found to be elevated both in patients with stable and unstable angina pectoris.…”

Section: Clinical Experience With Cxcr3 Binding Chemokines In Ischemimentioning

confidence: 99%

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The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction

et al. 2018

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The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development. Recent studies have indicated the role of these chemokines also in cardiovascular diseases. We aimed to present current knowledge regarding the role of CXCR3-binding chemokines in the pathogenesis of atherosclerosis and during acute myocardial infarction.

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Section: Clinical Experience With Cxcr3 Binding Chemokines In Ischemisupporting

confidence: 73%

Section: Clinical Experience With Cxcr3 Binding Chemokines In Ischemimentioning

confidence: 99%

The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction

et al. 2018

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“…It is particularly important in chronic inflammation, including atherosclerosis and hypertension (Ide et al , ). Circulating levels of CXCL10 are increased in hypertension (Antonelli et al , ) and coronary heart disease (Safa et al , ). CXCL10 exerts its biological effects mainly by binding to CXCR3.…”

Section: Chemokines In Pvat Inflammationmentioning

confidence: 99%

Perivascular adipose tissue inflammation in vascular disease

Nosalski

Guzik

2017

British J Pharmacology

300

237

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Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular characteristics. PVAT dysfunction is characterized by its inflammatory character, oxidative stress, diminished production of vasoprotective adipocyte-derived relaxing factors and increased production of paracrine factors such as resistin, leptin, cytokines (IL-6 and TNF-α) and chemokines [RANTES (CCL5) and MCP-1 (CCL2)]. These adipocyte-derived factors initiate and orchestrate inflammatory cell infiltration including primarily T cells, macrophages, dendritic cells, B cells and NK cells. Protective factors such as adiponectin can reduce NADPH oxidase superoxide production and increase NO bioavailability in the vessel wall, while inflammation (e.g. IFN-γ or IL-17) induces vascular oxidases and eNOS dysfunction in the endothelium, vascular smooth muscle cells and adventitial fibroblasts. All of these events link the dysfunctional perivascular fat to vascular dysfunction. These mechanisms are important in the context of a number of cardiovascular disorders including atherosclerosis, hypertension, diabetes and obesity. Inflammatory changes in PVAT's molecular and cellular responses are uniquely different from classical visceral or subcutaneous adipose tissue or from adventitia, emphasizing the unique structural and functional features of this adipose tissue compartment. Therefore, it is essential to develop techniques for monitoring the characteristics of PVAT and assessing its inflammation. This will lead to a better understanding of the early stages of vascular pathologies and the development of new therapeutic strategies focusing on perivascular adipose tissue.

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“…ATG16L2 is an autophagy-related gene recently proposed as an SLE risk locus (8), and is associated with multiple sclerosis (MS) (9) and Crohn's disease (10). CCL22 is a pro-inflammatory chemokine (11) secreted by macrophages and dendritic cells, and previously reported as a risk factor in ischemic heart disease (12) and MS (13). CCL22 binds to its receptor CCR4, found on dendritic cells in patients with liver inflammation (14).…”

Section: Introductionmentioning

confidence: 99%

Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci

et al. 2017

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We recently identified ten novel SLE susceptibility loci in Asians and uncovered several additional suggestive loci requiring further validation. This study aimed to replicate five of these suggestive loci in a Han Chinese cohort from Hong Kong, followed by meta-analysis (11,656 cases and 23,968 controls) on previously reported Asian and European populations, and to perform bioinformatic analyses on all 82 reported SLE loci to identify shared regulatory signatures. We performed a battery of analyses for these five loci, as well as joint analyses on all 82 SLE loci. All five loci passed genome-wide significance: MYNN Received: September 7, 2016. Revised: January 12, 2017. Accepted: January 13, 2017 ) of cis-genes. Transcription factor binding sites for p53, MEF2A and E2F1 were significantly (P < 0.05) over-represented in SLE loci, consistent with apoptosis playing a critical role in SLE. Enrichment analysis revealed common pathways, gene ontology, protein domains, and cell type-specific expression. In summary, we provide evidence of five novel SLE susceptibility loci. Integrated bioinformatics using all 82 loci revealed that SLE susceptibility loci share many gene regulatory features, suggestive of conserved mechanisms of SLE etiopathogenesis.

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Higher circulating levels of chemokines CXCL10, CCL20 and CCL22 in patients with ischemic heart disease

Cited by 50 publications

References 47 publications

The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction

The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction

Perivascular adipose tissue inflammation in vascular disease

Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci

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