Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study

Niu, Peng-Peng; Wang, Xue; Xu, Yuming

doi:10.3389/fnut.2022.907789

Cited by 9 publications

(6 citation statements)

References 58 publications

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“…A recent meta‐analysis of previous publications confirmed decreased serum 25‐hydroxyvitamin D levels in patients with migraine compared with controls 11 . Finally, a Mendelian randomization study involving three migraine datasets (48,975, 28,852, and 10,536 cases each) described an association between increased serum vitamin D levels and decreased risk for migraine 12 …”

Section: Introductionmentioning

confidence: 86%

“…11 Finally, a Mendelian randomization study involving three migraine datasets (48,975,28,852, and 10,536 cases each) described an association between increased serum vitamin D levels and decreased risk for migraine. 12 Buettner et al 13 described decreased risk for a headache of migraine type (although not with the severity of headache) in subjects with higher serum levels of vitamin D and statin use, in a series of 5938 participants. Serum vitamin D receptor levels have been found to be decreased, and serum vitamin D-binding protein levels are similar in migraine patients compared with controls in a single study.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D receptor and binding protein genes variants in patients with migraine

García‐Martín,

Navarro‐Muñoz,

Ayuso

et al. 2023

Ann Clin Transl Neurol

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Background/ObjectivesSeveral studies have shown a relationship between vitamin D and migraine, including the association between decreased serum 25‐hydroxyvitamin D in patients with migraine and the positive effects of vitamin D supplementations in the therapy of this disease. Two single‐nucleotide variants (SNVs) vitamin D receptor (VDR) gene, VDR rs2228570, and VDR rs731236 have shown an association with migraine risk in a previous case–control association study, while an exome sequencing study identified a rare variant in GC vitamin D binding protein gene. This study aims to look for the association between several common variants in these two genes and the risk for migraine.MethodsWe genotyped 290 patients diagnosed with migraine and 300 age‐matched controls using specific TaqMan assays for VDR rs2228570, VDR rs731236, VDR rs7975232, VDR rs739837, VDR rs78783628, GC rs7041, and GC rs4588 SNVs.ResultsWe did not find an association between these SNVs and the risk for migraine. None of these SNVs were related to the positivity of a family history of migraine or with the presence of aura. The VDR rs731236A allele showed a significant association with the triggering of migraine attacks by ethanol (Pc = 0.007).ConclusionsIn summary, the results of the current study suggest a lack of association between common SNVs in the VDR and GC gene and the risk of developing migraine. The possible relationship between VDR rs731236 and the triggering of migraine episodes with ethanol deserves future studies.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Vitamin D receptor and binding protein genes variants in patients with migraine

García‐Martín,

Navarro‐Muñoz,

Ayuso

et al. 2023

Ann Clin Transl Neurol

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“…We chose the 123 SNPs as candidate genetic instruments. We further performed a linkage disequilibrium clumping procedure using a wide, 10-Mb window and a stringent linkage disequilibrium threshold ( r 2 = 0.01) to identify independently significant SNPs ( Niu et al, 2022 ). The reference panel used was the European 1,000 Genome Project v3.…”

Section: Methodsmentioning

confidence: 99%

Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study

Wu,

Niu,

Liu

2024

Front. Genet.

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ObjectivePrevious observational studies have reported an increased risk of venous thromboembolism (VTE) among individuals with migraine. This study aimed to investigate the causal effect of migraine on the development of VTE, as well as explore the genetic correlation between them.MethodsWe conducted a two-sample Mendelian randomization (MR) study using publicly available summary statistics from large-scale genome-wide association studies for migraine and VTE. Linkage disequilibrium score regression analysis was performed to estimate the genetic correlation between migraine and VTE.ResultsThere were several shared risk variants (p-value < 5 × 10−8) between migraine and VTE. Linkage disequilibrium score regression analysis found a significant positive genetic correlation between migraine and VTE. The genetic correlations based on two migraine datasets were 0.208 (se = 0.031, p-value = 2.91 × 10−11) and 0.264 (se = 0.040, p-value = 4.82 × 10−11), respectively. Although main MR analysis showed that migraine was associated with an increased risk of VTE (odds ratio = 1.069, 95% confidence interval = 1.022–1.118, p-value = 0.004), the association attenuated to non-significance when using several other MR methods and using another set of genetic instruments. In addition, evidence of heterogeneity was found. Reverse MR analysis showed VTE was associated with increased risk of migraine with aura (odds ratio = 1.137, 95% confidence interval = 1.062–1.218, p-value = 2.47 × 10−4) with no evidence of pleiotropy and heterogeneity.ConclusionWe showed suggestive evidence indicating an association between migraine and increased risk of VTE. Additionally, we found robust evidence suggesting that VTE is associated with an increased risk of migraine. The positive genetic correlation indicates that migraine and VTE has shared genetic basis. Further investigations will be necessary to address potential sex-specific effects in the analysis.

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“…Several studies have reported that vitamin D low-serum levels may be associated with an increased risk of migraines/headaches [189]. In addition, it has been suggested that the prevalence of a deficiency/insufficiency of vitamin D may be greater in patients suffering from migraines/headaches when compared with subjects without headaches [190].…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

Di Lauro,

Guerriero,

Cornali

et al. 2023

Nutrients

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In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut–brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this context, in addition to conventional pharmacological treatments for migraine, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity, and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, and chronic kidney diseases, whose link is represented by gut dysbiosis.

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Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study

Cited by 9 publications

References 58 publications

Vitamin D receptor and binding protein genes variants in patients with migraine

Vitamin D receptor and binding protein genes variants in patients with migraine

Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study

Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

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