Higher clinical pregnancy rate with in-vitro fertilization versus intracytoplasmic sperm injection in treatment of non-male factor infertility: Systematic review and meta-analysis

Abbas, Ahmed M.; Hussein, Reda S.; Elsenity, Mohamed; Samaha, Ihab I.; Etriby, Karim A. El; El-Ghany, Mohamed F. Abd; Khalifa, Mansour A.; Abdelrheem, Shaimaa S.; Ahmed, Amira Y.; Khodry, Mostafa M.

doi:10.1016/j.jogoh.2020.101706

Cited by 25 publications

(15 citation statements)

References 43 publications

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“…Our study was not powered to investigate the effect of cryopreservation in subgroups of IVF and ICSI. Previous studies have shown no differences in first trimester embryonic growth and development (Hoek et al, 2020) and live birth rate (Abbas et al, 2020;Geng et al, 2020) between conventional IVF and ICSI pregnancies. However, the potential additional effect of the process of cryopreservation has not yet been investigated and therefore, future larger studies should take this technique into account.…”

Section: Discussionmentioning

confidence: 75%

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Duijn

Hoek

Rousian

et al. 2021

Reproductive BioMedicine Online

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Van Duijn & Hoek et al. 2020 3 Research question: Are there differences in prenatal growth trajectories and birth outcomes between singleton pregnancies conceived after in vitro fertilization (IVF) treatment with either frozen-thawed extended culture embryo transfer (ET) at day 5, fresh ET at day 3 or naturally conceived pregnancies? Design: From a prospective hospital-based cohort, a total of 859 singleton pregnancies were selected, including 133 conceived after IVF with frozen-thawed ET, 276 after fresh ET, and 450 naturally conceived pregnancies. Longitudinal three-dimensional (3D) ultrasound scans were performed at 7, 9 and 11 weeks of gestation for offline crown-rump length (CRL) and embryonic volume (EV) measurements. Second trimester estimated fetal weight was based on growth parameters obtained during the routine fetal anomaly scan at 20 weeks of gestation. Birth outcome data were collected from medical records.Results: No differences regarding embryonic growth trajectories were observed between frozenthawed ET and fresh ET. Birthweight percentiles after fresh ET were lower than after frozen-thawed ET (38.0 and 48.0 (p=0.046) respectively). The prevalence of non-iatrogenic preterm birth was significantly lower in pregnancies resulting from fresh ET as compared to frozen-thawed ET (4.7% and 10.9% (p=0.026) respectively). Compared to naturally conceived pregnancies, birthweight percentiles and percentage of non-iatrogenic PTB were significantly lower in pregnancies after fresh ET and gestational age at birth was significantly higher. Conclusion:Here we show that embryonic growth is comparable between singleton pregnancies conceived after fresh and frozen-thawed ET. The lower relative birthweight and PTB rate in pregnancies after fresh ET than after frozen-thawed ET and naturally conceived pregnancies warrants further investigation.

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Section: Discussionmentioning

confidence: 75%

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Duijn

Hoek

Rousian

et al. 2021

Reproductive BioMedicine Online

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“…An excessive use of ICSI, aiming at preventing cases of TFF, is thought to have negative consequences both on the overall probability of pregnancy and on the safety of the procedures with higher costs and increased laboratory workload. According to the results of a recent systematic review [ 6 ], TFF risk is significantly increased after conventional IVF insemination compared to ICSI (relative risk = 2.63, 95%CI: 1.29–5.35) in couples with non-male factor infertility; on the contrary, overall fertilization rates are not significantly improved with the use of ICSI and clinical pregnancy rates are even higher using conventional IVF. Similarly, a previous Cochrane review confirmed that conventional IVF gives better fertilization results than ICSI in couples with male factor subfertility and also suggested that pregnancy, miscarriage or live-birth rates after conventional IVF and ICSI are comparable for couple with non-male subfertility.…”

Section: Discussionmentioning

confidence: 99%

“…Its incidence following conventional insemination is not infrequent, being estimated to range between 5 and 20% [ 5 ]. Notably, however, evidence of improved fertilization results with the use of ICSI is still debated and strongly related to the infertility indication considered [ 6 – 9 ]. Furthermore, clues in support for the need to limit widespread use of ICSI stem from inconclusive data on improved post-fertilization reproductive outcomes for non-male factor infertility diagnosis and from the significantly higher rate of de novo, chromosomal abnormalities and birth defects observed in children born after ICSI compared with the rate in the general population [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis

Paffoni

Reschini

Pisaturo

et al. 2021

Reprod Biol Endocrinol

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Background Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasmic sperm injection (ICSI) has become the first choice over conventional in vitro fertilization (IVF) procedures although evidence of improved results is still debated and its use in couples without male factor infertility is not recommended. Among the strategies potentially useful to promote the use of conventional IVF, we herein call attention to the late rescue ICSI, which consists in performing ICSI after 18–24 h from conventional insemination on oocytes that show no signs of fertilization. This treatment has however been reported to be associated with a low success rate until recent observations that embryos derived from late rescue ICSI may be transferred after cryopreservation in a frozen-thawed cycle with improved results. The aim of the present study was to assess whether frozen embryos deriving from rescue ICSI performed about 24 h after conventional IVF may represent a valuable option for couples experiencing fertilization failure. Methods A systematic review on the efficacy of late rescue ICSI was performed consulting PUBMED and EMBASE. Results Including twenty-two original studies, we showed that clinical pregnancy rate per embryo transfer and implantation rate obtainable with fresh embryo transfers after rescue ICSI are not satisfactory being equal to 10 and 5%, respectively. The transfer of cryopreserved rescue ICSI embryos seems to offer a substantial improvement of success rates, with pregnancy rate per embryo transfer and implantation rate equal to 36 and 18%, respectively. Coupling rescue ICSI with frozen embryo transfer may ameliorate the clinical pregnancy rate for embryo transfer with an Odds Ratio = 4.7 (95% CI:2.6–8.6). Conclusion Results of the present review support the idea that r-ICSI coupled with frozen embryo transfer may overcome most of the technical and biological issues associated with fresh transfer after late r-ICSI, thus possibly representing an efficient procedure for couples experiencing fertilization failure following conventional IVF cycles. Trial registration Prospero registration ID: CRD42021239026.

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“…Additionally, clinics and/or physicians may be motivated to use ICSI for non-medical reasons, such as the availability of insurance or fear of poor outcomes, like TFF, without serious consideration of the potential adverse impact of its indiscriminate use. The use of ICSI is also presuming that TFF is due to sperm malfunction while not appreciating the complex nature of fertilization and embryo formation that go far beyond what ICSI can provide [48]. Finally, ICSI is not without potential harm of its own; this procedure has potential risks to oocytes and uncertain downstream effects on offspring.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review

Glenn

Kotlyar

Seifer

2021

JCM

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Intracytoplasmic sperm injection (ICSI) was originally designed to overcome barriers due to male factor infertility. However, a surveillance study found that ICSI use in non-male factor infertility increased from 15.4% to 66.9% between 1996 and 2012. Numerous studies have investigated fertilization rate, total fertilization failure, and live birth rate per cycle (LBR), comparing the use of ICSI versus conventional in vitro fertilization (IVF) for non-male factor infertility. The overwhelming conclusion shows no increase in fertilization rate or LBR per cycle with the use of ICSI for non-male factor infertility. The overuse of ICSI is likely related to the desire to avoid a higher rate of total fertilization failure in IVF. However, data supporting the benefit of using ICSI for non-male factor infertility is lacking, and 33 couples would need to be treated with ICSI unnecessarily to avoid one case of total fertilization failure. Such practice increases the cost to the patient, increases the burden on embryologist’s time, and is a misapplication of resources. Additionally, there remains conflicting data regarding the safety of offspring conceived by ICSI and potential damage to the oocyte. Thus, the use of ICSI should be limited to those with male factor infertility or a history of total fertilization factor infertility due to uncertainties of potential adverse impact and lack of proven benefit in non-male factor infertility.

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Higher clinical pregnancy rate with in-vitro fertilization versus intracytoplasmic sperm injection in treatment of non-male factor infertility: Systematic review and meta-analysis

Cited by 25 publications

References 43 publications

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Prenatal growth trajectories and birth outcomes after frozen–thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort

Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis

The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review

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