Higher concentration of serum C‐terminal cross‐linking telopeptide of type I collagen is positively related with inflammatory factors in postmenopausal women with H‐type hypertension and osteoporosis

Abstract

ObjectiveTo investigate the changes of inflammatory factors and bone metabolism markers in postmenopausal women with H‐type hypertension and to assess the relationship between them.MethodsPostmenopausal women who were diagnosed with osteoporosis were selected as observation objects. Participants were divided into three groups: only osteoporosis group (osteoporosis group), hypertension combined with osteoporosis group (hypertension group), and H‐type hypertension combined with osteoporosis group (H‐type hypertension group). The changes in bone mineral density and bone metabolic markers (osteocalcin [OC], procollagen type I N‐terminal propeptide (PINP), and C‐terminal cross‐linking telopeptide of type I collagen [CTX]) and inflammatory factors (interleukin‐6 [IL‐6] and tumor necrosis factor‐α [TNF‐α]) were compared among three groups.ResultsIn the hypertension group and the H‐type hypertension group, the bone mineral density of the lumbar spine (0.647 ± 0.038 vs 0.638 ± 0.034 vs 0.668 ± 0.047, P < 0.05) and the femoral neck (0.567 ± 0.047 vs 0.552 ± 0.053 vs 0.618 ± 0.059, P < 0.05) was significantly lower than that in the osteoporosis group. The concentrations of CTX (266.61 ± 64.65 vs 293.09 ± 72.34 vs 235.48 ± 62.85, P < 0.05), IL‐6 (44.36 ± 6.45 vs 48.05 ± 8.04 vs 39.06 ± 7.95, P < 0.05) and TNF‐α (30.53 ± 6.28 vs 34.52 ± 7.15 vs 28.66 ± 6.19, P < 0.01) in the hypertension group and in the H‐type hypertension group were significantly higher than those in the osteoporosis group. The concentrations of OC (30.59 ± 6.43 vs 27.10 ± 6.51, P < 0.05) and PINP (36.36 ± 6.16 vs 33.16 ± 6.77, P < 0.05) in the H‐type hypertension group were increased dramatically. The concentration of CTX was positively correlated with the concentration of IL‐6 (r = 0.587, P < 0.01) and TNF‐α (r = 0.474, P < 0.01) and negatively related with the concentration of OC (r = −0.591, P < 0.01) and PINP (r = −0.646, P < 0.01) and the bone mineral density of the lumbar spine (r = −0.470, P < 0.01) and the femoral neck (r = −0.509, P < 0.01).ConclusionHigher concentration of serum CTX is found in postmenopausal women with H‐type hypertension, which is positively correlated with inflammatory factors. Besides, H‐type hypertension could further enhance the activity of osteoclasts and increase the expressions of inflammatory factors, resulting in the aggravation of osteoporosis.

Assessment of the effect of estradiol on biochemical bone turnover markers among postmenopausal women

“…No effect of estradiol on these relationships was noted. Different results were presented by Chen YN et al [22], who indicated that the serum level of Ctx was positively related with both TNF-α and IL-6. In addition, they confirmed an increase in the levels of bone turnover markers Ctx and OC, and pro-inflammatory cytokines TNF-α and IL-6 in the examined postmenopausal women.…”

“…These differences may result from the characteristics of the examined women which differed from those in the presented study. In a study by Chen YN et al, in which participated women diagnosed with osteoporosis and additional, accompanying diseases, including pro-inflammatory cardiovascular diseases [22].…”

Hypertension and reduced bone mineral density: unexpected pathogenetic mechanisms

“…"H-hypertension"), которая включает в себя эссенциальную гипертензию и гипергомо цистеинемию. В одной из работ оценивалась связь некоторых маркеров костного метаболизма, включая CTX-I, с маркерами воспаления и значениями МПК у женщин постменопаузального возраста [39]. В группе "Г-гипертензии" МПК в области поясничного отдела позвоночника и шейки бедренной кости была значительно ниже, чем в группе остеопороза [39].…”

Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension

“…More than 75% of patients with hypertension in China have increased levels of homocysteine (Hcy), which is considered H-type hypertension when Hcy ≥ 10 µmol/L [ 1 ]. Patients with H-type hypertension are more susceptible to osteoporosis [ 2 ] and to stroke [ 3 ]. Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in Hcy metabolism [ 4 ].…”