Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

Finch, Sarah L.; Rosenberg, Alan; Kusalik, Anthony; Maleki, Farhad; Rezaei, Elham; Baxter-Jones, Adam D.G.; Benseler, Susanne M.; Boire, Gilles; Cabral, David A.; Campillo, Sarah; Chédeville, Gaëlle; Chetaille, Anne-Laure; Dancey, Paul; Duffy, Ciarán M.; Duffy, Karen Watanabe; Guzman, Jaime; Houghton, Kristin; Huber, Adam M.; Juřenčák, Roman; Lang, Bianca; Laxer, R. M.; Morishita, Kimberly; Oen, Kiem; Petty, Ross E.; Ramsey, Suzanne; Roth, Johannes; Schneider, Rayfel; Scuccimarri, Rosie; Stringer, Elizabeth; Tse, Shirley M. L.; Tucker, Lori B.; Turvey, Stuart E.; Szafron, Michael; Whiting, Susan J.; Yeung, Rae S. M.; Vatanparast, Hassan

doi:10.1016/j.nutres.2021.05.007

Cited by 8 publications

(12 citation statements)

References 32 publications

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“…In this multicenter cross-sectional study of 4–16-year-old children with JIA, nearly one-third had insufficient serum vitamin D levels. Consistent with other studies [ 25 – 30 , 49 ], we found no difference between boys and girls, but in contrast, our results showed clear differences in vitamin D related to age. We did not find any associations between serum vitamin D levels and JIA-related disease characteristics, but there was an association between vitamin D insufficiency and dentin caries, and gingival bleeding.…”

Section: Discussionsupporting

confidence: 92%

“…This may be one explanation for the higher mean vitamin D results in our Norwegian JIA cohort, compared to two studies performed in Turkey [ 27 , 28 ]. The geographical differences in serum vitamin D levels in JIA are further reflected by three studies performed in central and south America, and Canada where the vitamin D levels in JIA were considerably higher than in our study population [ 24 , 30 , 49 ]. This might be the result of more exposure to sunlight, more frequent vitamin D fortification of foods and beverages, or a higher intake of supplements.…”

Section: Discussionmentioning

confidence: 46%

“…The relatively few studies that compare vitamin D levels in JIA to controls have shown inconsistent results. Some studies have found no difference in vitamin D levels [ 29 , 30 ], while others have found lower [ 26 , 28 ] or higher mean vitamin D levels in JIA versus controls [ 25 , 49 ]. The lack of sun exposure during a large part of the year in Norway has led to strong national health recommendations for vitamin D supplementation for all children and adults in the form of cod-liver oil or other vitamin D supplements.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study

et al. 2022

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Background Vitamin D deficiency has been associated with autoimmune diseases and oral health. Knowledge about the association between vitamin D status and oral conditions in JIA is limited. We aimed to investigate vitamin D status in a cohort of Norwegian children and adolescents with JIA and possible associations between serum vitamin D levels, clinical indicators of oral health, and JIA disease characteristics. Methods This multi-center, cross-sectional study, included individuals with JIA aged 4–16 years from three geographically spread regions in Norway. Demographic data, age at disease onset, disease duration, JIA category, disease status, medication, and vitamin D intake were registered. One blood sample per individual was analyzed for 25(OH) vitamin D, and the level of insufficiency was defined as < 50 nmol/L. A clinical oral examination was performed applying commonly used indices in epidemiological studies of dental caries, dental erosion, enamel defects, gingival bleeding, and oral hygiene. Serum vitamin D was used as exposure variable in multivariable regression analyses to estimate the associations between insufficient vitamin D level, JIA disease status, and oral conditions, with adjustments for age, sex, geographical region, BMI, seasonal blood sampling, and parental education. Results Among the 223 participants with JIA, 97.3% were Caucasians, 59.2% were girls, and median age was 12.6 years. Median disease duration was 4.6 years, and 44.4% had oligoarticular JIA. Mean serum vitamin D level was 61.4 nmol/L and 29.6% had insufficient levels. Vitamin D levels did not differ between sexes, but between regions, iso-BMI categories, age groups, and seasons for blood sampling. Insufficient vitamin D levels were associated with dentin caries (adjusted OR 2.89, 95% CI 1.43–5.86) and gingival bleeding (adjusted OR 2.36, 95% CI 1.10–5.01). No associations were found with active JIA disease or more severe disease characteristics. Conclusion In our study, nearly 30% had vitamin D insufficiency, with a particularly high prevalence among adolescents. Vitamin D insufficiency was associated with dentin caries and gingival bleeding, but not with JIA disease activity. These results point to the need for a multidisciplinary approach in the follow-up of children with JIA, including an increased focus on vitamin D status and oral health.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

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Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study

et al. 2022

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“…Традиционно наше представление об обеспеченности витамином D детей было по сравнению со взрослыми было более оптимистичным в связи с большей приверженностью детей к приему профилактических доз холекальциферола [1,2]. Однако недавние исследования с включением различных по величине когорт пациентов свидетельствуют о низкой обеспеченности 25(ОН)D как среди практически здоровых детей вне зависимости от региона их проживания, так и среди детей с различными отклонениями в состоянии здоровья [3][4][5][6][7][8][9][10][11][12][13]. Основная проблема исследований по обеспеченности витамином D заключается в отсутствии комплексного подхода, то есть динамической оценки 25(ОН)D в течение всего периода детства и в различные сезоны года.…”

Section: актуальностьunclassified

“…факультетской педиатрии с курсом детских болезней лечебного факультета Одинаева Нуринисо Джумаевна, д. м. н., профессор, директор Хавкин Анатолий Ильич, д. м. н., профессор, руководитель Московского областного центра детской гастроэнтерологии, гепатологии и абдоминальной хирургии, главный научный сотрудник отдела педиатрии Пономаренко Юлия Борисовна, врач-педиатр Шубина Юлия Федоровна, заведующая централизованной клинико-диагностической лабораторией-врач клинической лабораторной диагностики Голеницкая Ирина Альбертовна, научный сотрудник Паснова Екатерина Витальевна, заведующая отделением муковисцидоза https://doi.org /10.31146/1682-8658-ecg-202-6-5-13 Обсуждение. Выявлена высокая частота выраженного дефицита витамина D среди детей с онкологическими заболеваниями (41,7%), заболеваниями нервной системы (12,9) и системы крови (10,9). Было показано, что выраженный дефицит 25(ОН)D имеет 25,0% детей с церебральным параличом, 19,4% детей с хронической болезнью почек, 16,7% -с сахарным диабетом 1 типа, 15,5% с ювенильным идиопатическим артритом, 14,8% пациентов с анемией, 10,3% с воспалительными заболеваниями кишечника, 7,9% детей, рожденных недоношенными.…”

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Seasonal fluctuations in vitamin D levels in children with various diseases

Kondratyeva

Loshkova

Odinaeva

et al. 2022

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The main problem of research on vitamin D sufficiency is the lack of an integrated approach, that is, a dynamic assessment of 25(OH)D throughout the entire period of childhood and in different seasons of the year. This is necessary to highlight those specific diseases in which priority targeted prevention and therapy of hypovitaminosis will be indicated, taking into account the numerous biological and pathophysiological effects of vitamin D metabolites, in particular, 25(OH)D, which have socially significant clinical consequences. The aim of the study: to assess the level of 25(OH)D in children with various diseases living in Moscow and the Moscow region, taking into account the season of the year and age. Materials and methods. A study was made of the availability of 25(OH)D among 1501 children living in Moscow and the Moscow regions. Discussion. A high frequency of severe vitamin D deficiency was found among children with oncological diseases (41.7%), diseases of the nervous system (12.9) and blood system (10.9). It was shown that 25.0% of children with cerebral palsy, 19.4% of children with chronic kidney disease, 16.7% with type 1 diabetes mellitus, 15.5% with juvenile idiopathic arthritis have a pronounced deficiency of 25(OH)D, 14.8% of patients with anemia, 10.3% with inflammatory bowel disease, 7.9% of children born prematurely. Conclusion. Severe and year-round disorders of 25(OH)D metabolism were noted in children suffering from autoimmune (type 1 diabetes mellitus, inflammatory bowel disease, idiopathic juvenile arthritis), oncological diseases, cerebral palsy, prematurity, and chronic kidney disease.

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Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19

et al. 2023

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Evidence supporting the extra-skeletal role of vitamin D in modulating immune responses is centred on the effects of its final metabolite, 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 , also known as calcitriol), which is regarded as a true steroid hormone. 1,25(OH) 2 D 3 , the active form of vitamin D, can modulate the innate immune system in response to invading pathogens, downregulate inflammatory responses and support the adaptive arm of the immune system. Serum concentrations of its inactive precursor 25-hydroxyvitamin D 3 (25(OH)D 3 , also known as calcidiol) fluctuate seasonally (being lowest in winter) and correlate negatively with the activation of the immune system as well as with the incidence and severity of autoimmune rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. Thus, a low serum concentration of 25(OH)D 3 is considered to be a risk factor for autoimmune rheumatic diseases and vitamin D 3 supplementation seems to improve the prognosis; moreover, long-term vitamin D 3 supplementation seems to reduce their incidence (i.e. rheumatoid arthritis). In the setting of COVID-19, 1,25(OH) 2 D 3 seems to downregulate the early viral phase (SARS-CoV-2 infection), by enhancing innate antiviral effector mechanisms, as well as the later cytokine-mediated hyperinflammatory phase. This Review provides an update of the latest scientific and clinical evidence concerning vitamin D and immune response in autoimmune rheumatic diseases and COVID-19, which justify the need for monitoring of serum 25(OH)D 3 concentrations and for appropriate supplementation following clinical trial-based approaches.

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Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

Cited by 8 publications

References 32 publications

Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study

Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study

Seasonal fluctuations in vitamin D levels in children with various diseases

Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19

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