Study Objectives: Oronasal masks are frequently used for continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA). The aim of this study was to (1) determine if CPAP requirements are higher for oronasal masks compared to nasal mask interfaces and (2) assess whether polysomnography and patient characteristics differed among mask preference groups. Methods: Retrospective analysis of all CPAP implementation polysomnograms between July 2013 and June 2014. Prescribed CPAP level, polysomnography results and patient data were compared according to mask type (n = 358). Results: Oronasal masks were used in 46%, nasal masks in 35% and nasal pillow masks in 19%. There was no difference according to mask type for baseline apnea-hypopnea index (AHI), body mass index (BMI), waist or neck circumference. CPAP level was higher for oronasal masks, 12 (10-15.5) cm H 2 O compared to nasal pillow masks, 11 (8-12.5) cm H 2 O and nasal masks, 10 (8-12) cm H 2 O, p < 0.0001 (Median [interquartile range]). Oronasal mask type, AHI, age, and BMI were independent predictors of a higher CPAP pressure (p < 0.0005, adjusted R 2 = 0.26.). For patients with CPAP ≥ 15 cm H 2 O, there was an odds ratio of 4.5 (95% CI 2.5-8.0) for having an oronasal compared to a nasal or nasal pillow mask. Residual median AHI was higher for oronasal masks (11.3 events/h) than for nasal masks (6.4 events/h) and nasal pillows (6.7 events/h), p < 0.001. Conclusions: Compared to nasal mask types, oronasal masks are associated with higher CPAP pressures (particularly pressures ≥ 15 cm H 2 O) and a higher residual AHI. Further evaluation with a randomized control trial is required to definitively establish the effect of mask type on pressure requirements. Keywords: obstructive sleep apnea, CPAP, treatment, mask, nasal pillows, nasal mask, oronasal mask Commentary: A commentary on this article appears in this issue on page 1209. Citation: Deshpande S, Joosten S, Turton A, Edwards BA, Landry S, Mansfield DR, Hamilton GS. Oronasal masks require a higher pressure than nasal and nasal pillow masks for the treatment of obstructive sleep apnea. J Clin Sleep Med 2016;12(9):1263-1268.
I NTRO DUCTI O NObstructive sleep apnea (OSA) is characterized by excessive daytime sleepiness due to recurrent episodes of partial (hypopnea) or complete (apnea) obstruction of the upper airway during sleep. OSA is highly prevalent and moderate-severe OSA is reported to affect 17% of men and 9% of women older than 50 years.1 Untreated OSA is associated with significant morbidity and mortality, with increased risk of hypertension, depression, motor vehicle accidents, cardiovascular disease, and premature death.2-5 The mainstay of therapy for OSA is nocturnal continuous positive airway pressure (CPAP), which prevents collapse by pneumatically splinting the upper airway. CPAP has been shown to reduce daytime somnolence, improve quality of life, and improve nocturnal oxygen saturation. 6 CPAP has also been shown to reduce blood pressure, and in severe OSA, c...