2022
DOI: 10.47825/jkgp.2022.26.2.76
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Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition

Abstract: Objective: We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition. Methods: MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F] flutemetamol, and bioelectrical … Show more

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“…The global amyloid standardized uptake value ratio (SUVR) was quantified by automated segmentation software based on deep‐learning model (SCALE PET v. 0.1.3.1 by Neurophet, South Korea) 21 using pons as the reference region 22 . A cutoff value of 0.62 for global SUVR was used to determine amyloid‐positivity, as described in previous studies 23,24 …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The global amyloid standardized uptake value ratio (SUVR) was quantified by automated segmentation software based on deep‐learning model (SCALE PET v. 0.1.3.1 by Neurophet, South Korea) 21 using pons as the reference region 22 . A cutoff value of 0.62 for global SUVR was used to determine amyloid‐positivity, as described in previous studies 23,24 …”
Section: Methodsmentioning
confidence: 99%
“… 22 A cutoff value of 0.62 for global SUVR was used to determine amyloid‐positivity, as described in previous studies. 23 , 24 …”
Section: Methodsmentioning
confidence: 99%