Higher HOMA-IR Index Is Associated With Increased Excess Weight Loss in Patients With BMI ≥ 35 kg/m2 After Vertical Gastrectomy

Casas-Tapia, Cristina; Araujo‐Castillo, Roger V.; Saavedra-Tafur, Lil; Bert-Dulanto, Aimeé; Piscoya, Alejandro; Casas-Lucich, Alberto

doi:10.1016/j.cireng.2020.06.003

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…The fact that the results are non-significant for the fourth year of follow-up may be explained by missing data due to loss to follow-up, which decreases the power for finding any significant difference. Despite not being in accordance with some studies in this area ( 13 – 15 ), our results are in accordance with the results described by Casas-Tapia et al at 1 year post-vertical gastrectomy ( 17 ). This might be due to the anabolic role of insulin ( 32 ).…”

Section: Discussionsupporting

confidence: 55%

“…Also, Souteiro et al showed that patients with complete diabetes remission after bariatric surgery lost more weight ( 16 ). Contrarily, Casas-Tapia et al recently described an association of higher HOMA-IR with increased excess weight loss after vertical gastrectomy in 91 patients ( 17 ). Further evidence from Diedisheim et al is in agreement with this hypothesis ( 18 ).…”

Section: Introductionmentioning

confidence: 97%

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Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

et al. 2021

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BackgroundObesity is a multifactorial disease, which is strongly associated to other metabolic disorders. Bariatric surgery is the most effective treatment of morbid obesity. The role of beta cell function in weight loss after bariatric surgery is uncertain.AimTo evaluate the association between beta cell function and percentage of total body weight loss (TBWL%) 1, 2, 3, and 4 years after bariatric surgery in patients with morbid obesity.MethodsRetrospective longitudinal study in patients with morbid obesity followed in our center between January 2010 and July 2018. Patients were excluded if they had diabetes at baseline or missing data on the needed parameters. We evaluated baseline Homeostatic Model Assessment of IR, Homeostatic Model Assessment of β-cell function (HOMA-beta), Quantitative Insulin Sensitivity Check Index, and Matsuda and DeFronzo index, and TBWL% at years 1 to 4. Linear regression models were used to evaluate the association of indexes of insulin resistance with TBWL% (unadjusted and adjusted for age, sex, BMI, and type of surgery).ResultsThere were 1,561 patients included in this analysis. HOMA-beta was negatively associated with TBWL% at second, third, and fourth years post-surgery (β = −1.04 [−1.82 to −0.26], p<0.01; β = −1.16 [−2.13 to −0.19], p=0.02; β = −1.29 [−2.64 to 0.06], p=0.061, respectively). This was not observed in the first year post-surgery nor for the other indexes. Glycemia at baseline was positively associated to EWL% at second and third years post-surgery.Conclusionβ-cell function at baseline seems to be associated to long-term weight loss, explicitly after the first year post bariatric surgery. This might be a helpful predictor of weight loss in clinical practice.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 97%

Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

et al. 2021

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“…In the study conducted by Casa-Tapia et al, an association was found between a higher preoperative HOMA-IR and increased weight loss 1 year after surgery. [28] The difference between the 2 studies could be attributed to the different patient groups included in the studies. Our study was conducted with nondiabetic patients, while the other study included patients with diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Assessing the predictive value of the suppressed 1 mg overnight dexamethasone suppression test in success of bariatric surgery

Şirikçi,

Kiraç,

Findikli

et al. 2024

Medicine

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Bariatric surgery has been proven to be a successful intervention for managing obesity. There are numerous studies in the literature aiming to predict the factors influencing the success of bariatric surgery. Our study aims to determine whether preoperative 1 mg overnight dexamethasone suppression test (1 mg-DST) serum cortisol levels can serve as predictors of the effectiveness of bariatric surgery in severe obese patients without Cushing syndrome. A total of 98 patients who underwent bariatric surgery were included in the study. The preoperative 1 mg-DST levels, insulin levels, thyroid function tests, and lipid profiles of the patients were recorded. The patients’ preoperative, postoperative 3rd, and 6th month weights were recorded and the percent total weight loss (%TWL) is calculated. Patients were categorized into 2 groups based on their TWL at 6 months. The 1 mg-DST results were significantly lower in the high-TWL-6 group (0.93 ± 0.37 μg/dL) compared to the low-TWL-6 group (1.09 ± 0.36 μg/dL, P = .040). Similarly, Homeostatic Model Assessment for Insulin Resistance values were lower in the high-TWL-6 group (5.63 ± 2.21) compared to the low-TWL-6 group (6.63 ± 2.55, P = .047). The optimal cutoff value found for 1 mg-DST level was 0.97 µg/dL, providing 50% sensitivity and 70% specificity. This study is the first to examine the predictive role of suppressed 1 mg-DST levels on postoperative weight loss in nondiabetic patients. The most prominent result of this study was that we observed a negative correlation between 1 mg-DST levels and %TWL.

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“…En el 2020 Cristina Casas-Tapia et al, describieron que los pacientes que tenían diabetes mellitus tipo 2 y un HOMA IR más alto se asociaba con una mayor pérdida de exceso de peso en pacientes con obesidad con IMC ≥ 35 Kg/m² mediante la cirugía bariátrica con técnica de manga gástrica al año de seguimiento (40).…”

Section: Estado Del Arteunclassified

Efecto de la cirugía bariátrica sobre la resistencia a la insulina en pacientes sin diabetes mellitus a un año de seguimiento

Díaz Posada

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Introducción: La obesidad no es solo un problema estético, es una enfermedad que viene en aumento alcanzando una prevalencia en Colombia del 18% para el 2015 según la encuesta ENSIN, la cual incrementa el riesgo cardiovascular asociado a la resistencia a la insulina (RI) y componente proinflamatorio crónico asociado a la adiposidad. Se desea conocer el impacto de la cirugía bariátrica en la perdida de peso según la resistencia a la insulina medida por HOMA-IR en nuestra población. Metodología: Cohorte mediante análisis de base de datos secundarios-anonimizados, recolectados entre 2016-2021 en una institución de alta complejidad en la ciudad de Bucaramanga, Santander, Colombia que fueron llevados a Gastrectomía vertical (GV) o Bypass gástrico (BGYR) con seguimiento a un año. Resultados: Respecto a la obesidad se logró normalización del IMC en el 42% llevados a GV y 26% a BGYR. En cuanto al síndrome metabólico de 94 pacientes cumplían criterios IDF adaptados a nuestra población previo a la intervención quirúrgica 60% GV y 20% BGYR persistiendo en menos del 2% en cada grupo posterior a un año esta condición. La RI en el grupo de BGYR pasó del 79,7% al 11,3% y en GV pasó del 86,5% al 23%. Conclusiones: La cirugía bariátrica es una herramienta eficaz para disminuir la RI, siendo este efecto mayor en la BGYR. Adicionalmente se demostró remsión del síndrome metabólico en el 98% que tenían esta condición previa al procedimiento.

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Higher HOMA-IR Index Is Associated With Increased Excess Weight Loss in Patients With BMI ≥ 35 kg/m2 After Vertical Gastrectomy

Cited by 3 publications

References 28 publications

Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

Assessing the predictive value of the suppressed 1 mg overnight dexamethasone suppression test in success of bariatric surgery

Efecto de la cirugía bariátrica sobre la resistencia a la insulina en pacientes sin diabetes mellitus a un año de seguimiento

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