Higher Homologous Cyanoacrylate Tissue Adhesives in Surgery of Internal Organs

Anastomose do nervo facial de coelhos com cola de fibrina: estudo da velocidade de condução nervosa

“…The fibrin glue used in the present study (Tissucol®, Immuno AG, Viena, Austria) was the same one used by Maragh et al 32 . Many authors [5][6][7]16,18,22,30,34,42,43 have analyzed new anastomosis alternatives in order to optimize nerve regeneration. The main options include the use of artificial nerve conduction means, CO 2 laser and tissue adhesive or glue.…”

“…Fibrin glue is a plasma-derived biologic concentrate of topical use, of which mechanism of action is similar to the last stage of the physiological coagulation (fibrinogen formation). The clot constituted by the glue is a physiologic component found in tissue repair, and this makes it different from other types of glue such as the cyanoacrylates, which bear high fibrin formation and is very difficult to use in moist tissue [17][18][19][20][21][22][23][24] . The fibrin glue Tissucol® (Immuno AG, Viena, Austria) commercially presents itself in two components, fibrinogen and the catalyst that, mixed by means of the Duploject® system (Immuno AG, Viena, Austria), solidify and form a plasmatic clog.…”

Efeito do adesivo butil-2-cianoacrilato em osteotomias e enxerto ósseo em coelhos: aspecto macroscópico e radiográfico

“…Thus, a longer observation period will be necessary in order to determine the time taken for the adhesive and its action on tissues to be eliminated. It has been recognized that esters with greater numbers of carbon atoms degrade slowly, and some authors have suggested that complete removal of the adhesive may never be attained (6,7,15,17,20,26) .…”

“…Cyanoacrylates are a group of fast-polymerization adhesives that started to be used in surgery in the 1960s (5) . These would make it possible to use this method, since they are absorbable, biocompatible, easy to use, cost--cost, sterilizable in ethylene oxide and radiotransparent, and have the property of adhering to wet surfaces (6) .…”

Isobutyl cyanoacrylate as a skin adhesive

“…The cyanoacrylate monomers, especially methyl, have been used in both experimental (Healey, 1962) and clinical surgery (Vasko, 1965) to bind together moist living tissues, for example to seal wounds of the kidney and spleen and also to reinforce suture anastomoses. The recently introduced isobutyl cyanoacrylate (Matsumoto, 1967) is less toxic than the lower homologues and its experimental use as a tissue adhesive has recently been reported (Hale & Ellis, 1968).…”