Higher infant body fat with excessive gestational weight gain in overweight women

Hull, Holly R.; Thornton, John C.; Ji, Ying; Paley, Charles; Rosenn, Barak; Mathews, Premila; Navder, Khursheed; Yu, Amy W; Dorsey, Karen; Gallagher, Dympna

doi:10.1016/j.ajog.2011.04.004

Cited by 121 publications

(147 citation statements)

References 26 publications

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“…Recent findings demonstrate that neonates born from overweight mothers who exceed GWG recommendations have greater body fat percentage and greater fat mass compared to their offspring born to women who gained within the guidelines [60] which strengthens previous findings suggesting a strong link between GWG and downstream childhood obesity [61,62].…”

Section: Maternal Obesity Gestational Weight Gain Insulin Resistancsupporting

confidence: 74%

An examination of maternal contributors and potential modifiers of fetal growth in pregnancy

Ferraro

2013

Appl. Physiol. Nutr. Metab.

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A greater understanding of critical periods of body weight regulation, including pregnancy, may aid in efforts to optimize weight management strategies for the mother and her baby.The gestational period has been implicated to play, in the child, a vital role in the developmental origins of obesity and other cardiometabolic diseases later in life. Therefore, we initially examined existing literature on the role of maternal obesity and its link to pediatric obesity and documented the known underlying physiological mechanisms responsible for this relationship while suggesting potential intervention targets that may improve maternal-fetal outcomes. In a second paper, we aimed to quantify maternal predictors of large for gestational age (LGA) neonates in the Ottawa and Kingston (OaK) birth cohort with specific hypotheses verifying the independent contribution of maternal prepregnancy body mass index (BMI) and excessive gestational weight gain (GWG) to fetal overgrowth. This paper also highlights the clinical utility of the revised 2009 Institute of Medicine GWG guidelines and discusses the potential role of physiological factors underlying the observed associations between BMI, excessive GWG and LGA neonates. As a follow-up to our population-level analysis (i.e., OAK cohort), papers three and four highlight how the insulin-like growth factor (IGF) axis, a vital regulator of growth and development, may be compromised at the molecular level in cases of maternal obesity (paper 3) and excessive GWG (paper 4). In paper 3 we show that maternal obesity is associated with attenuated expression of IGF binding protein-4 (IGFBP4) in umbilical cord blood and discuss how this may preferentially promote fetal adipogenesis. The effects of excessive GWG on IGF axis protein expression are addressed in paper four where we show iii that excessive weight gain during pregnancy is associated with increased expression of IGFBP3 in maternal circulation in normoglycemic term pregnancies. In this paper we discuss the potential inhibitory role of IGFBP3 on adipogenesis and how it relates to glucose intolerance during pregnancy. Recognizing that both obesity and excessive GWG can alter physiological processes in mother and her baby, appropriate evidence-based interventions are warranted to best optimize outcomes. In paper five, we discuss the results of a study which sought to assess patient information channels and knowledge of nutrition and physical activity during pregnancy with the intent that these findings be applied to best design efficacious strategies that cater to the needs of our target group of pregnant women. In our analysis we show that the majority of pregnant women studied would be willing to participate in a lifestyle intervention for their own personal health and that of their child. Of great interest was the observation that most women were not informed of the importance of pregnancy-specific energy intake, or made aware of their own healthy GWG targets. Additionally, many of the respondents reported receiving no info...

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Section: Maternal Obesity Gestational Weight Gain Insulin Resistancsupporting

confidence: 74%

An examination of maternal contributors and potential modifiers of fetal growth in pregnancy

Ferraro

2013

Appl. Physiol. Nutr. Metab.

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“…Among the 20 articles that met the inclusion criteria, six included both exposures 6,27,28,29,30,31 . The average score of the selected articles was 15.4, with a minimum of 13 and a maximum of 18.…”

Section: Resultsmentioning

confidence: 99%

“…The increase in the prevalence of maternal obesity in recent decades 9,10 has occurred in parallel with the increment of large for gestational age newborns 11,12,13 and an increased incidence of childhood obesity 14 . Female offspring of obese women are most likely to be obese predisposing their children to obesity, insulin resistance and diabetes 6,15,16 . Several studies have shown that a high increment in maternal gestational weight gain associated with increased offspring body mass index (BMI) 17,18,19 whereas other studies have reported no such association 20,21 .…”

Section: Introductionmentioning

confidence: 99%

“…Pre-pregnancy and gestational maternal body composition may impact offspring body fat mass at birth, in childhood and in adolescence, and may also predict the risk of obesity in adulthood 4,5,6,7,8 . The increase in the prevalence of maternal obesity in recent decades 9,10 has occurred in parallel with the increment of large for gestational age newborns 11,12,13 and an increased incidence of childhood obesity 14 .…”

Section: Introductionmentioning

confidence: 99%

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Maternal obesity and offspring body composition by indirect methods: a systematic review and meta-analysis

et al. 2015

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Maternal obesity and offspring body composition by indirect methods: a systematic review and meta-analysis Obesidad maternal y composición corporal de los hijos por métodos indirectos: revisión sistemática y metaanálisisObesidade materna e composição corporal dos filhos por métodos indiretos: revisão sistemática e meta-análises 95%CI: 0.19; 0.42), 0.38kg (95%CI: 0.26; 0.50), 0.42), respectively. Evidence so far suggests that pre-pregnancy maternal overweight is associated with higher offspring adiposity.

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“…Rates of excessive GWG have been increasing over me and research has shown that greater GWG is associated with increased weight of baby at birth and infancy [24][25][26][27] . This raises ques ons about the long-term adverse eff ects of higher weight gains in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Review of Trimester-Specific Gestational Weight Gain and Childhood Adiposity

Thapa

2014

J. Nepal Paedtr. Soc.

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Childhood obesity is a global epidemic and a major public health challenge. There has been increasing evidence that intrauterine exposures, such as alcohol, smoking, and maternal nutritional status, may affect both the long and short term health consequences of the mother and offspring. Childhood adiposity may be affected by the mother's pre-pregnancy weight and her weight gain during pregnancy. Consequently, interventions may need to start before conception of the child to prevent childhood obesity. In 2009, the Institute of Medicine updated its gestational weight gain recommendations by incorporating rates of gestational weight gain in the second and third trimesters based on the mother's pre-pregnancy Body Mass Index. There is extensive research on the association between total gestational weight gain and short-term offspring adiposity. However, this review focuses on the association between trimester-specific gestational weight gain and childhood adiposity for singleton pregnancies with respect to the Institute of Medicine's newly defined weight gain recommendations as very few studies have examined the association between the gestational weight gain during each trimester and childhood adiposity. Identifying the trimester that is most associated with childhood adiposity may help in the development of targeted interventions, guide physician's nutritional and weight-gain recommendations for child-bearing mothers, and direct future research.

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Higher infant body fat with excessive gestational weight gain in overweight women

Cited by 121 publications

References 26 publications

An examination of maternal contributors and potential modifiers of fetal growth in pregnancy

An examination of maternal contributors and potential modifiers of fetal growth in pregnancy

Maternal obesity and offspring body composition by indirect methods: a systematic review and meta-analysis

Review of Trimester-Specific Gestational Weight Gain and Childhood Adiposity

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