Higher intakes of dietary vitamin D, calcium and dairy products are inversely associated with the risk of colorectal cancer: a case–control study in China

Zhang, Xin; Yu, Fang; Feng, Xiaoli; Abulimiti, Alinuer; Huang, Chuyi; Luo, Hong; Zhang, Naiqi; Chen, Yuming; Zhang, Caixia

doi:10.1017/s000711451900326x

Cited by 28 publications

(20 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary branched-chain amino acids and cancer effect modification was observed in the model including dairy products, whose consumption is partially correlated with Ca intake. Only the adjustment for fish consumption and vitamin D slightly increased the OR estimates (0•82 and 0•87 for the highest v. the lowest quintile of BCAA intake, respectively), suggesting a possible role of vitamin D, in addition to Ca, in explaining the observed associations with CRC, in line with the literature (23)(24)(25)(26) . In an additional model, including both dietary Ca and vitamin D, no association with BCAA was evident.…”

Section: Discussionsupporting

confidence: 82%

Dietary intake of branched-chain amino acids and colorectal cancer risk

et al. 2020

View full text Add to dashboard Cite

ABSTACT An adequate intake of branched-chain amino acids (BCAAs) is required for protein synthesis and metabolic functions, including insulin metabolism. Emerging studies found positive associations between BCAAs and the risk of various diseases sharing etiological aspects with colorectal cancer (CRC), including type 2 diabetes, obesity, and pancreatic cancer. We investigated the relation between dietary BCAAs and CRC using data from a multicentric Italian case-control study, including 1953 cases of CRC (of these, 442 of sigmoid colon) and 4154 hospital controls with acute, non-neoplastic diseases. A validated food-frequency questionnaire was used to estimate the participants’ usual diet and to assess dietary intakes of various nutrients, including energy, BCAAs and calcium. Odds ratio (ORs) and corresponding confidence intervals (CI) were computed by multiple logistic regression models adjusted for age, sex and other confounding factors, including total energy intake. BCAA intake was inversely related to CRC risk (OR for the highest versus the lowest quintile, 0.73; 95% CI, 0.55-0.97), but the association was attenuated after adjustment for calcium intake (OR, 0.90; 95% CI, 0.65-1.25). A linear inverse association with sigmoid colon cancer risk remained also after adjustment for other dietary factors, including calcium intake (OR, 0.49; 95% CI, 0.27-0.87). This study provides supporting evidence that higher levels of dietary BCAA intake are not associated with an increase of CRC risk, but confirms that they may be related to a reduced risk of sigmoid colon cancer.

show abstract

Section: Discussionsupporting

confidence: 82%

Dietary intake of branched-chain amino acids and colorectal cancer risk

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Several epidemiological studies, meta-analyses, and supplemental studies have tried to determine the specific role of circulating, dietary, and/or supplemental vitamin B12 with CRC risk, although the results are still controversial. For example, two meta-analyses of prospective and case-control studies and a case-control study evaluated the association between circulating and vitamin B12 intake and CRC risk, which concluded that dietary vitamin B12 was inversely associated with the risk of CRC [23][24][25]. However, other studies did not find significant associations between CRC risk and neither dietary [26] nor serum vitamin B12 [27,28].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients

et al. 2020

View full text Add to dashboard Cite

Vitamin B12 has been widely related to methionine metabolism, which is an essential component for biological methylation reactions, including DNA methylation. However, the relationship between vitamin B12 and DNA methylation is still controversial. In addition, there is increasing evidence for the association between vitamin B12 and the risk of colorectal cancer (CRC), although results of this association need to be assessed with caution. For this purpose, we hypothesized that serum vitamin B12 could be associated with global DNA methylation in the CRC context. To test this hypothesis, we studied the association between global DNA methylation through long interspersed nuclear element-1 (LINE1) in CRC patients under the 25th percentile of serum vitamin B12. We found that the high vitamin B12 group had low LINE1 methylation in both tumor area and peripheral blood mononuclear cells (PBMCs) than the low serum vitamin B12 group. LINE1 methylation levels were significantly lower in tumor area compared to the adjacent tumor-free area, only in the high vitamin B12 group. LINE1 methylation in visceral adipose tissue (VAT) and PBMCs were correlated with tumoral, inflammatory, and insulin metabolism markers. However, the interaction between LINE1 methylation and vitamin B12 levels was associated with neoadjuvant therapy in the regression analysis only in men, suggesting a beneficial relationship. In conclusion, our results reported an inverse association between DNA methylation and vitamin B12 in the CRC context, which suggests that vitamin B12 may be implicated in an epigenetic state or mediation in CRC.

show abstract

“…Case-control studies from Korea [6], Japan [16], China [17] and two women cohorts from the European Prospective Investigation into Cancer and Nutrition (EPIC) study [18] also reached the same conclusion, while other studies [19][20][21][22] have shown no association between colorectal cancer risk and high dietary calcium intake. The variance in these findings is likely due to differences in intake of calcium-based foods resulting from differences in food cultures.…”

Section: Discussionmentioning

confidence: 61%

Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study

et al. 2021

View full text Add to dashboard Cite

Dietary calcium intake has been suggested to be protective against the development of colorectal cancer. The mean dietary calcium intake of Koreans is 490 mg/day, which is far below the recommended calcium intake of 700-800 mg/day. In this study, we explored the relationship between dietary calcium intake and colorectal cancer development in Koreans with relatively low calcium intake compared with individuals in Western countries. Materials and Methods The Health Examinees Study, a large-scale genomic community-based prospective cohort study, was designed to identify the general characteristics of major chronic diseases in Koreans. A total of 119,501 participants aged 40-69 years recruited between 2004 and 2013 were included in this analysis. The calcium intake level was categorized using the Dietary Reference Intakes for Koreans (KDRIs). The Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and the corresponding 95% confidence intervals (CIs) for colorectal cancer risk, adjusting for potential confounders. Results In the multivariable-adjusted model, compared with the group that consumed less than the recommended amount of calcium, the group that consumed more than the recommended intake of calcium showed a significant reduction in the risk of colorectal cancer in women. (HR, 0.54; 95% CI, 0.31 to 0.95). Among men, however, no significant association was observed between dietary calcium intake and colorectal cancer risk (HR, 0.89; 95% CI, 0.54 to 1.45). Conclusion Korean women who adhere to the recommended intake of calcium showed a reduced risk of colorectal cancer.

show abstract

Higher intakes of dietary vitamin D, calcium and dairy products are inversely associated with the risk of colorectal cancer: a case–control study in China

Cited by 28 publications

References 52 publications

Dietary intake of branched-chain amino acids and colorectal cancer risk

Dietary intake of branched-chain amino acids and colorectal cancer risk

Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients

Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study

Contact Info

Product

Resources

About