Higher Ki67 Index, Nodal Involvement, and Invasive Growth Were High Risk Factors for Worse Prognosis in Conventional Mammary Analogue Secretory Carcinoma

Sun, Jingjing; Wang, Lizhen; Tian, Zhen; Hu, Yuhua; Xia, Ronghui; Jiang, Li

doi:10.1016/j.joms.2019.01.002

Cited by 17 publications

(21 citation statements)

References 41 publications

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“…with a detailed description in 2014. Another 13 cases of SCHG have since been reported 3,4,9,15–18 . A summary of these 14 cases and the present case is shown in Table 1.…”

Section: Discussionmentioning

confidence: 66%

“…Locoregional radiation therapy may be selected for patients with positive or close margins or perineural invasion, and systemic chemotherapy is considered for distant metastases 5,14 . A Ki‐67 index >10% may be an independent prognostic factor for recurrence‐free survival and disease‐free survival 15 . However, in a combination of three large series of studies on secretory carcinoma, only one (1.0%, 1/100) patient died of secretory carcinoma 6,14,15 …”

Section: Discussionmentioning

confidence: 99%

“…A Ki‐67 index >10% may be an independent prognostic factor for recurrence‐free survival and disease‐free survival 15 . However, in a combination of three large series of studies on secretory carcinoma, only one (1.0%, 1/100) patient died of secretory carcinoma 6,14,15 …”

Section: Discussionmentioning

confidence: 99%

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High‐grade salivary gland carcinoma with the ETV6‐NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high‐grade transformation

Asai

Saito

Yamada

et al. 2021

Pathology International

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Secretory carcinoma or mammary analog secretory carcinoma is an entity of salivary gland carcinoma that is characterized by the ETV6‐NTRK3 gene fusion. Although it is generally considered to be a low‐grade malignancy, some cases of secretory carcinoma with high‐grade transformation (SCHG) have been reported. We herein describe a case of SCHG composed almost exclusively of the high‐grade component. The patient presented with a growing mass in the buccal mucosa and underwent surgery. Tumor cells showing high‐grade nuclear atypia were arranged in solid or cribriform nests with comedo‐like necrosis. A differential diagnosis included high‐grade salivary gland carcinoma, such as salivary duct carcinoma. Immunohistochemically, tumor cells were focally positive for S‐100 and negative for mammaglobin and showed nuclear positivity for pan‐Trk. A reverse transcription polymerase chain reaction assay showed that the tumor harbored the ETV6‐NTRK3 gene fusion. A histological review of microscopic slides of the tumor did not reveal a typical secretory carcinoma component, except for a very focal area. We ultimately diagnosed this tumor as SCHG. This case underscores the importance of recognizing the histological spectrum of SCHG and the utility of pan‐Trk immunohistochemistry to detect secretory carcinoma, which may be targeted by tyrosine kinase inhibitors.

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“…with a detailed description in 2014. Another 13 cases of SCHG have since been reported 3,4,9,15–18 . A summary of these 14 cases and the present case is shown in Table 1.…”

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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High‐grade salivary gland carcinoma with the ETV6‐NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high‐grade transformation

Asai

Saito

Yamada

et al. 2021

Pathology International

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“…In SC, the first case of HGT was reported by Jung et al, the authors noted the histological feature resemble to high-grade differentiated acinic carcinoma [17]. As far as I searched, only 16 cases HGT SC has been reported [7,8,11,[17][18][19][20][21]. Histologically, the high-grade transformation area is characterized by solid growth with atypical tumor cells and the high-grade transformation area with comedo necrosis adjacent to follicular structure site tend to demonstrate a more aggressive nature and ultimately a poor prognosis [6].…”

Section: Discussionmentioning

confidence: 99%

“…The high-grade transformation behaves more aggressively and is more associated with a poor prognosis than a low-grade tumor. SC with high-grade histology is rare and only 16 cases have been reported to this date [7,8,11,[17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

Takabatake

Nakano

Kawai

et al. 2020

Reports

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Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.

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Fluorescence in situ hybridization for ETV6 gene rearrangements on destained cytological smears: Role in diagnosis of secretory carcinoma of salivary gland

Mahendru

Sarma

Kakkar

et al. 2023

Cancer Cytopathology

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Background Fine‐needle aspiration cytology (FNAC) is the first‐line diagnostic procedure for salivary gland masses. Secretory carcinoma (SC) is characterized by ETV6 and RET rearrangements detected by fluorescence in situ hybridization (FISH) or reverse transcriptase‐polymerase chain reaction optimized for paraffin‐embedded and fresh‐frozen tissue, respectively. The authors performed FISH on cytological material to assess its role in the diagnosis of SC. Methods FNACs with SC as a diagnostic consideration and cases diagnosed as SC on histology with a corresponding FNAC with any diagnosis were evaluated for ETV6 rearrangement by FISH. If acinic cell carcinoma (ACC) was a differential diagnosis and ETV6 rearrangement was absent, NR4A3 FISH was performed. FISH results were compared with those on histological specimens, where available. Results Fifteen cases were included. FISH initially performed on three cell blocks did not yield good results, was then performed on direct smears, and was interpretable in 14 cases (93.3%). An ETV6 rearrangement was identified in seven cases (50%), and an NR4A3 rearrangement was identified in three cases (21.4%), providing a confirmatory diagnosis in 10 of 15 cases (66.7%). The Milan System for Reporting Salivary Gland Cytopathology category was altered in two cases (6.7%). Complete correlation (100%) was seen with FISH on corresponding histological specimens. Conclusions With minor modifications, the FISH procedure can be optimized for FNAC smears with results comparable to those on histological specimens. ETV6 FISH testing on cytological smears in cases suspected as SC improves the diagnostic accuracy of FNAC and can help lower the proportion of the Milan categories salivary gland neoplasm of uncertain malignant potential and suspicious for malignancy, maximizing diagnostic information from less invasive samples and aiding in patient management.

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Higher Ki67 Index, Nodal Involvement, and Invasive Growth Were High Risk Factors for Worse Prognosis in Conventional Mammary Analogue Secretory Carcinoma

Cited by 17 publications

References 41 publications

High‐grade salivary gland carcinoma with the ETV6‐NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high‐grade transformation

High‐grade salivary gland carcinoma with the ETV6‐NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high‐grade transformation

Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

Fluorescence in situ hybridization for ETV6 gene rearrangements on destained cytological smears: Role in diagnosis of secretory carcinoma of salivary gland

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