Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis

Knippenberg, Stephanie; Damoiseaux, Jan; Bol, Yvonne; Hupperts, Raymond; Taylor, Bruce; Ponsonby, Anne–Louise; Dwyer, Terence; Simpson, Steve; Mei, Ingrid van der

doi:10.1111/ane.12155

Cited by 58 publications

(67 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further studies are required to translate the findings of our murine studies to humans. However, our results support recent calls for clinical trials that test the efficacy of skin exposure to sunlight or UVR for the control of chronic diseases like multiple sclerosis (39) and depression (40), which, like obesity and MetS, may take years to develop. In conclusion, our studies show that long-term low-dose sunlight exposure may be an effective means of suppressing obesity and MetS in mice fed a high-fat diet, through pathways that are independent of vitamin D and at least partially dependent on skin-derived NO.…”

Section: Discussionsupporting

confidence: 85%

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

et al. 2014

View full text Add to dashboard Cite

The role of vitamin D in curtailing the development of obesity and comorbidities such as the metabolic syndrome (MetS) and type 2 diabetes has received much attention recently. However, clinical trials have failed to conclusively demonstrate the benefits of vitamin D supplementation. In most studies, serum 25-hydroxyvitamin D [25(OH)D] decreases with increasing BMI above normal weight. These low 25(OH)D levels may also be a proxy for reduced exposure to sunlight-derived ultraviolet radiation (UVR). Here we investigate whether UVR and/or vitamin D supplementation modifies the development of obesity and type 2 diabetes in a murine model of obesity. Long-term suberythemal and erythemal UVR significantly suppressed weight gain, glucose intolerance, insulin resistance, nonalcoholic fatty liver disease measures; and serum levels of fasting insulin, glucose, and cholesterol in C57BL/6 male mice fed a high-fat diet. However, many of the benefits of UVR were not reproduced by vitamin D supplementation. In further mechanistic studies, skin induction of the UVR-induced mediator nitric oxide (NO) reproduced many of the effects of UVR. These studies suggest that UVR (sunlight exposure) may be an effective means of suppressing the development of obesity and MetS, through mechanisms that are independent of vitamin D but dependent on other UVR-induced mediators such as NO.Obesity has significant effects on our health and wellbeing: obese people have increased comorbidities resulting from cardiovascular disease, type 2 diabetes, breast and colon cancers, dementia, and depression. Vitamin D deficiency is recognized as a health problem affecting many individuals worldwide (1) and may contribute to the development of obesity. Insufficient levels of vitamin D are associated with obesity, and obese people are more likely than others to be vitamin D deficient (reviewed in Earthman et al.

show abstract

Section: Discussionsupporting

confidence: 85%

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In MS, we observed associations between depressive symptoms and 25(OH)D levels [52,246] , raising hope for a beneficial effect of vitamin D supplements in this particular disease. Despite well-known immune regulatory properties of vitamin D, we previously did not observe an effect of vitamin D supplements on depression related immunological outcomes in non-depressed MS patients (chapter 5).…”

mentioning

confidence: 77%

“…However, they were not maintained after adjustment for confounders [52] . By contrast, sun exposure was found to be associated with depression in MS, independent of 25(OH)D levels [246] . Therefore, previous studies showing associations between vitamin D and depression may have captured associations as an epiphenomenon.…”

mentioning

confidence: 83%

“…Therefore, particularly in the context of the chronic inflammation in MS, vitamin D supplementation might prevent or ameliorate depressive disorder. However, data appear conflicting with respect to the role of vitamin D in depressive disorder in patients with MS [52,246] , and with respect to the benefit of vitamin D supplementation in depression in general [247] . Therefore we used a randomized placebo-controlled trial (RCT) to explore the effect of high dose vitamin D 3 supplementation on depressive symptoms in MS.…”

Section: Sex (F/m)mentioning

confidence: 99%

“…Increasing the available levels of vitamin D therefore may help to reduce inflammation and/or depression in MS. Thus far, however, data from association and supplementation studies with respect to vitamin D and depression have been inconsistent and inconclusive, also in MS [52,246] . In an exploratory study we did not observe a beneficial effect of high-dose vitamin D 3 supplementation on symptoms and immunological biomarkers of depression in MS (chapter 5).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Mapping the effects of vitamin D in multiple sclerosis

Rolf¹

View full text Add to dashboard Cite

Columbus (1451Columbus ( -1506 on one of his four voyages Er zijn verrassend veel parallellen te trekken tussen onderzoek doen en een van mijn favoriete vrijetijdsbestedingen, namelijk koken. Alles begint met een inspiratie, nieuwsgierigheid en een idee. Dan volgt de planning en de uitvoering en na (lang…) wachten kun je het resultaat proeven. Het blijft altijd spannend of het gelukt is en of het wel lekker is. Als het lekker is, dan smaakt het vaak ook naar meer! Zo niet, dan moet je het recept aanpassen, of crucialer, iets heel anders verzinnen...De weg naar een goed gelukt gerecht is, althans voor mij, minstens zo belangrijk: watertandend recepten zoeken en menu's samenstellen, op zoek gaan naar de juiste producten, lekker creatief combineren en (al of niet met succes) uitproberen. Dat kon ook in de voor mij nieuwe keuken van de wetenschap, en wel in een restaurant met een excellente ambiance. Verder is de diversiteit aan smaken, waar ik bij eten zo van houd, zeker ook terug te vinden in de verschillende hoofdstukken.Of kookkunsten gewaardeerd worden is vervolgens een kwestie van smaak, maar ook van kennis. De fijnproevers zullen zich op de details storten en boeren die het niet kennen zullen het niet eten, maar voor iedereen die aan tafel schuift: hopelijk is datgene wat in dit boekje geserveerd wordt smakelijk en levert het gespreksstof op voor het natafelen! Abbreviations and glossary & G L O S S A R Y AB BR EVI ATI ONS 23General IntroductionHistorical explorers discovered new land around the world, and with every journey more details have been added to global maps. For multiple sclerosis research, explorers of the 20 th century put vitamin D on the map, and from 2008 onwards, our research team in Maastricht has tried to add more details to this area. Today, vitamin D in multiple sclerosis is still an active area of research. Many reviews concentrate on the role of vitamin D in multiple sclerosis, illustrated by clinical and immunological studies. Also in this thesis two reviews elaborate on this topic. Therefore, the introduction to this thesis is restricted to the essential players, i.e. multiple sclerosis, its immune pathogenesis, and vitamin D, followed by the outline of the thesis.Multiple sclerosis (MS) is the most common disabling neurological disease among young people. Initial symptoms generally occur in the age of 20-40 years and MS affects women 2-3 times more often compared to men [1][2] . Currently, almost 1 in 1000 people suffers from MS in the Netherlands [3] . MS is characterized by inflammation and neurodegeneration of the central nervous system (CNS; brain and spinal cord). Though, it is still a matter of debate whether it is neurodegenerative or inflammatory from onset [1,4] . Most accepted, however, is the thought that inflammatory processes lead to damage of the fatty myelin sheaths covering the neuronal axons, which normally support fast transduction of signals, and this process is called demyelination. The inflammation can be accompanied by axonal injury and over time this result...

show abstract

Lifestyle Medicine for the Prevention and Treatment of Depression

Sarris

O’Neil

2016

Lifestyle Medicine

View full text Add to dashboard Cite

Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis

Abstract: We found that higher levels reported sun exposure, rather than 25(OH)D levels, were associated with less depressive symptoms and levels of fatigue. The role of UV or light therapy will need to be evaluated in randomized controlled trials to confirm an effect on these symptoms in MS.

Cited by 58 publications

References 37 publications

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet

Mapping the effects of vitamin D in multiple sclerosis

Lifestyle Medicine for the Prevention and Treatment of Depression

Contact Info

Product

Resources

About