This paper proposes a hybrid data‐driven and physics‐based simulation technique for seismic response evaluation of steel Buckling‐Restrained Braced Frames (BRBFs) considering brace fracture. Buckling‐Restrained Brace (BRB) fracture is represented by cumulative plastic deformation capacity. A dataset, consisting of 95 past BRB laboratory tests and 120 simulated BRB responses generated using the finite element method, is first developed. An Artificial Neural Network‐based (ANN) predictive model is then trained using the training dataset to estimate the cumulative plastic deformation of BRBs. The prediction capability of the ANN‐based predictive model is validated using the training dataset and an existing regression‐based predictive model. In the second part of the paper, an hybrid simulation technique combining the data‐driven model and physics‐based numerical modeling is presented to conduct the nonlinear time history analysis, followed by 1) validation against a full‐scale BRBF testing and 2) demonstration of the proposed simulation technique using a six‐story BRBF. The results confirm that the proposed predictive model can predict the BRB fracture with sufficient accuracy. Furthermore, the hybrid data‐driven physics‐based simulation technique can be used as a powerful tool for dynamic analysis of BRBFs considering BRB fracture.