Higher morning serum cortisol level predicts increased fibrinogen but not shortened APTT

Abstract

The results of this retrospective investigation confirm that baseline cortisol levels might predict higher fibrinogen in the general population. This potential biological interrelationship deserves further scrutiny for the potential implications on prediction and prevention of the cardiovascular risk.

The impact of sleep restriction while performing simulated physical firefighting work on cortisol and heart rate responses

“…Furthermore, the results highlight the protective role an 8-h sleep opportunity between shifts of simulated firefighting work has on preserving normal cortisol levels when compared to a 4-h sleep opportunity. Given the number of adverse health outcomes associated with chronically high cortisol levels (Lippi et al 2008;Mackin and Young 2004;Rosmond et al 2003;Silverman and Sternberg 2012), future research should examine how prolonged exposure to firefighting work and restricted sleep (e.g. long or multiple deployments over a fire season) affects firefighters' cortisol levels in the medium to longer term.…”

“…Furthermore, heart disease is the leading cause of on-duty death among firefighters (Kales et al 2007). Given the association between chronically elevated cortisol and CVD (Lippi et al 2008;Rosmond et al 2003) and other adverse health effects (e.g. mood disorders; Mackin and Young 2004), these findings draw further attention to the need for research that investigates the effects of longer and chronic exposure to wildland firefighting work and restricted sleep on long-term cortisol levels.…”

“…Growing evidence suggests that chronically high diurnal cortisol levels both near and above the normal levels are positively associated with increased CVD risk (Lippi et al 2008;Prodam et al 2013;Rosmond et al 2003). Furthermore, heart disease is the leading cause of on-duty death among firefighters (Kales et al 2007).…”

Natural Remedies Lower Elevated Fibrinogen Levels in the Prevention of Atherosclerosis

“…There is a strong statistical correlation between moderate to high levels of chronic psychological stress over extended periods, elevated plasma fibrinogen concentration, and CVD in various studies [30][31][32][33].…”

“…Lippi et al studied the morning serum cortisol and fibrinogen levels in 302 patients and found a strong statistical relationship between elevated levels of both inflammatory markers [30]. They found morning cortisol levels that were higher on the reference parameters equated with higher fibrinogen levels [33].…”