The large‐amplitude vibration of initially stressed functionally graded material (FGM) rectangular plates with porosities is investigated in this paper. All edges of the plate are simply supported and uncompressed edges are tangentially restrained. Initial stresses are caused by in‐plane compressive load acting on freely movable edges or thermally induced forces at restrained edges. Pores present in FGM through even and uneven distributions. Material properties are assumed to be temperature‐dependent and, due to the presence of the pores, the effective properties of FGM are determined using a modified rule of mixture. Governing equations in terms of deflection and stress function are established based on the classical plate theory taking into account von Kármán nonlinearity and initial geometric imperfection. These equations are solved using approximate analytical solutions along with the Galerkin method to obtain a time differential equation containing quadratic and cubic nonlinear terms. Nonlinear frequencies are determined by means of numerical integration employing the fourth‐order Runge–Kutta scheme. Parametric studies are carried out to analyze the effects of material and geometry properties, porosity volume fraction and distribution, pre‐existent compressive and thermal loads, imperfection and degree of tangential constraints of unloaded edges on the natural frequencies and nonlinear to linear frequency ratio of FGM plates.