Higher oxidative balance score is associated with lower kidney stone disease in US adults: a population-based cross-sectional study

Lei, Xiong; Wen, Hezhi; Xu, Zhixiao

doi:10.1007/s00345-024-04919-0

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…The Oxidative Balance Score (OBS) employed in our study is a comprehensive composite measure comprising 20 factors representing dietary and lifestyle pro-oxidants and antioxidants, which has been extensively validated across multiple studies ( 26 – 29 ). The pro-oxidant factors (total fat, iron, alcohol, BMI, cotinine) are well-established contributors to oxidative stress through mechanisms such as free radical generation, lipid peroxidation, inflammatory processes, and endogenous oxidative burden.…”

Section: Discussionmentioning

confidence: 99%

Association of oxidative balance score with chronic kidney disease: NHANES 1999-2018

Wen,

Li,

Chen

et al. 2024

Front. Endocrinol.

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BackgroundThe Oxidative Balance Score (OBS), which quantifies the balance between antioxidants and pro-oxidants influenced by diet and lifestyle, is crucial given oxidative stress’s significant role in Chronic Kidney Disease (CKD). This study aims to determine the association between OBS and CKD using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018. OBS was constructed from a detailed array of 20 factors, including dietary nutrients and lifestyle behaviors. The relationship between OBS and CKD risk was evaluated using weighted logistic regression models, adjusted for potential confounders, with a generalized additive model (GAM) examining non-linear associations. Subgroup analyses and interaction effects across diverse demographic and clinical groups, along with sensitivity analyses, were performed to validate the findings.ResultsAmong 32,120 participants analyzed, 4,786 were identified with CKD. Fully adjusted weighted logistic regression analysis revealed that each unit increase in OBS was associated with a 2% reduction in CKD prevalence [OR: 0.98 (0.98–0.99), P < 0.001]. Higher OBS quartiles were significantly correlated with a decreased CKD risk [Q4 vs. Q1: OR: 0.82 (0.68–0.98), P = 0.03; P for trend = 0.01]. The GAM and smoothed curve fit indicated a linear relationship between OBS and the risk of CKD. Stratified and sensitivity analyses further substantiated the inverse relationship between OBS and CKD prevalence.ConclusionsOur findings from the NHANES data affirm a significant inverse association between OBS and CKD risk in the U.S. population, underscoring the role of optimizing dietary and lifestyle factors in managing CKD risk. These results advocate for incorporating OBS considerations into CKD prevention and treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Association of oxidative balance score with chronic kidney disease: NHANES 1999-2018

Wen,

Li,

Chen

et al. 2024

Front. Endocrinol.

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Association of systemic immune-inflammation index with body mass index, waist circumference and prevalence of obesity in US adults

Yang,

Zhang,

Deng

et al. 2024

Sci Rep

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Relationship of oxidative balance score to gallstone prevalence and gallbladder surgery in American adults: evidence from NHANES 2017-2020

Wei,

Yu,

et al. 2024

Preprint

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Gallstones represent a common gastrointestinal disorder, affecting approximately 10-20% of the global population. Oxidative stress plays a pivotal role in the pathogenesis of gallstones; however, there remains a lack of effective clinical indicators to predict their formation. This study addresses this gap by investigating the relationship between oxidative balance score (OBS) and the incidence of gallstones and gallbladder surgery, utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020. Methods: This study investigated the association between OBS and the occurrence of gallstones and gallbladder surgery by analyzing data from NHANES for the period 2017–2020, adjusting for potential confounders such as age, sex, race, and comorbidities. Various statistical analyses were applied, including multivariate logistic regression, subgroup analyses, and smoothed curve-fitting models.Results: The results revealed a significant negative correlation between OBS and the risks of both gallstones and gallbladder surgery, with each one-unit increase in OBS associated with a 2.6% reduction in gallstone risk (OR=0.974, 95% CI: 0.958-0.990) and a 3.3% reduction in the risk of gallbladder surgery (OR=0.967, 95% CI: 0.950-0.983). Subgroup analyses confirmed the consistency of these associations across various demographic and health-related factors. Furthermore, a dose-response relationship was observed between higher OBS and a reduced risk of gallbladder surgery.Conclusions: This study demonstrates that a higher OBS is associated with a lower incidence of gallstones and reduced rates of gallbladder surgery, offering new insights into the link between oxidative stress levels and gallstone formation as well as surgical intervention. The findings underscore the potential of OBS as a valuable tool for identifying at-risk populations and informing personalized prevention strategies for gallstone disease.

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Higher oxidative balance score is associated with lower kidney stone disease in US adults: a population-based cross-sectional study

Cited by 3 publications

References 27 publications

Association of oxidative balance score with chronic kidney disease: NHANES 1999-2018

Association of oxidative balance score with chronic kidney disease: NHANES 1999-2018

Association of systemic immune-inflammation index with body mass index, waist circumference and prevalence of obesity in US adults

Relationship of oxidative balance score to gallstone prevalence and gallbladder surgery in American adults: evidence from NHANES 2017-2020

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