Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette-smoking men.

Dullaart, Robin; Hoogenberg, Klaas; Dikkeschei, Bert D.; Tol, Arie van

doi:10.1161/01.atv.14.10.1581

Cited by 105 publications

(70 citation statements)

References 36 publications

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“…The median levels of cholesterol, HDL, LDL, lipoprotein A, APOA1 and APOB are shown in table 3 [Dahlen et al, 1986;Dullaart et al, 1994;Foger et al, 1994;Sandkamp et al, 1990;Walldius et al, 2001] .…”

Section: Resultsmentioning

confidence: 99%

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Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

et al. 2008

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Introduction: Sudden sensorineural hearing loss (SSHL) has been proposed as a symptom of underlying vascular problems. The purpose of this work is to evaluate the genetic and acquired risk factors. Methods: Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess genetic risk factors, and several parameters classically associated with vascular disorders (cardiovascular events, brain stroke and antiphospholipid syndrome) were evaluated. Additional assessments of personal and familial history risk factors for vascular disorders were performed in each patient. Results: Thrombophilia studies did not demonstrate statistically relevant differences between the patients and control group. However, lipidemia profile and directed personal and familial histories showed positive trends for SSHL. Conclusion: The lack of clear relationships between SSHL and other vascular risk factors suggests multicausality as a predominant disease profile. Although preliminary results point at a vascular involvement in SSHL, a long-term prospective study is necessary to demonstrate that SSHL represents an early vascular symptom.

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Section: Resultsmentioning

confidence: 99%

“…The plasma APOA1 concentration is lower in smokers than in nonsmokers, and exercise training increases the plasma level of APOA1 [Dullaart et al, 1994;Foger et al, 1994]. Several epidemiological studies have revealed an inverse relationship between coronary artery disease and the plasma APOA1.…”

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Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

et al. 2008

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“…Lifestyle factors further complicate this issue: it has been described that alcohol abuse and physical exercise, typically associated with increased HDL-c, are associated with diminished CETP concentration (55,71,72). Similarly, smoking (associated with low HDL-c) is associated with high CETP activity (73,74). A cross-sectional study showed an inverse relation between CETP and HDL-c among hypertriacylglycerolemic but not normotriacylglycerolemic men (75).…”

Section: Cetp and Dyslipidemia Which Comes First?mentioning

confidence: 99%

A review of CETP and its relation to atherosclerosis

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Klerkx

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et al. 2004

Journal of Lipid Research

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“…In a normolipidemic population, the plasma CETP concentration varies mostly over a threefold range and is influenced by environmental factors (6). Plasma CETP has been shown to be elevated in smokers and to be decreased by heavy alcohol drinking and physical training (7)(8)(9).…”

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Relationship Between TaqIB Cholesteryl Ester Transfer Protein Gene Polymorphism and Macrovascular Complications in Japanese Patients With Type 2 Diabetes

et al. 2002

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Cholesteryl ester transfer protein (CETP) is a key regulating factor of lipid metabolism, and the polymorphism of its gene may therefore be a candidate for modulating the lipid parameters, altering the susceptibility to atherosclerosis in type 2 diabetic subjects. In a group of 443 unrelated Japanese patients with type 2 diabetes, we studied the B1B2 polymorphism at the CETP locus, which is detectable with the restriction enzyme TaqI. Patients were separated into three groups according to genotype and compared based on their clinical characteristics, lipid parameters, and macrovascular complications. The B2 allele was associated in a dose-dependent fashion with higher HDL cholesterol and apolipoprotein AI levels, together with lower CETP concentrations. Furthermore, the prevalence of macrovascular complications, such as coronary heart disease, arteriosclerosis obliterans, and cerebral vascular disease, was significantly higher in subjects with the B1B1 genotype. Multiple logistic regression analysis also showed that the B1 allele of CETP genotype was associated with the incidence of these three complications independently of other risk factors. Thus, in type 2 diabetic patients, the B1B2 polymorphism of CETP gene is likely to be a strong genetic predictor of macrovascular complications. Diabetes 51:871-874, 2002 T ype 2 diabetic patients are at high risk of atherosclerotic diseases, such as coronary heart disease (CHD), cerebral vascular disease (CVD), or arteriosclerosis obliterans (ASO) (1). This increased risk can be partly accounted for by the lipoprotein disorders linked to insulin resistance: elevated VLDL, triglycerides, and cholesterol, together with low HDL cholesterol (2). The inverse relationship between the level of HDL cholesterol and the risk of cardiovascular disease is commonly explained by the crucial role of HDL in reverse cholesterol transport (3-5). By this process, cholesterol from peripheral cells is taken up by HDL and transported to the liver, where it is metabolized and excreted in the bile. Cholesteryl ester transfer protein (CETP) has a central role in the metabolism of HDL lipoprotein and may therefore alter the susceptibility to atherosclerotic vascular disease (3). In a normolipidemic population, the plasma CETP concentration varies mostly over a threefold range and is influenced by environmental factors (6). Plasma CETP has been shown to be elevated in smokers and to be decreased by heavy alcohol drinking and physical training (7-9).Recently, the B1B2 polymorphism of intron 1 of the CETP gene (presence or absence of a TaqIB restriction site) was shown to be a determinant of HDL cholesterol (10). It has been reported that both healthy and type 2 diabetic subjects with the B2B2 genotype of TaqIB polymorphism have significantly higher HDL cholesterol levels than those with the B1B1 or B1B2 genotype (11,12). Furthermore, in subjects with the B2B2 genotype, the progression of coronary atherosclerosis is more greatly suppressed by pravastatin than in those with the B1B1 or B1B2 genotype,...

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Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette-smoking men.

Cited by 105 publications

References 36 publications

Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

A review of CETP and its relation to atherosclerosis

Relationship Between TaqIB Cholesteryl Ester Transfer Protein Gene Polymorphism and Macrovascular Complications in Japanese Patients With Type 2 Diabetes

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