Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to longer perfluoroalkyl acids

Costantini, David; Blévin, Pierre; Herzke, Dorte; Moe, Børge; Gabrielsen, Geir Wing; Bustnes, Jan Ove; Chastel, Olivier

doi:10.1016/j.envres.2018.10.003

Cited by 59 publications

(31 citation statements)

References 59 publications

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“…Animal studies have also shown that PFAS disrupt normal thyroid function [56] and biosynthesis of thyroid and reproductive hormones [55,57]. Another possible mechanism may be elevated oxidative stress, which has been associated with increased odds of PTB [58] and is hypothesized to be a downstream consequence of PFAS exposure [59]. PBDEs may affect birth outcomes through disruption of thyroid function.…”

Section: Discussionmentioning

confidence: 99%

Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco

et al. 2020

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Background Perfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) are used in consumer products for their water repellent and flame retardant properties, respectively. However, there is widespread prenatal exposure and concern about their potential harm to the developing fetus. Here, we utilized data from a demographically diverse cohort of women in San Francisco, CA to examine associations between prenatal exposure to PFAS and PBDEs with gestational age and birth weight for gestational age z-scores. Methods Women included in this analysis were enrolled in the Chemicals in our Bodies (CIOB) cohort study (N = 506). PFAS and PBDEs were measured in serum obtained during the second trimester of pregnancy. Linear regression models were used to calculate crude and adjusted β coefficients for the association between PFAS and PBDE concentrations in tertiles and gestational age and birth weight z-scores. Individual PFAS and PBDE concentrations, as well as their sums, were examined in separate models. Results The highest compared to lowest tertile of BDE-47 was associated with shorter gestational age (β = − 0.49, 95% confidence interval [CI] = − 0.95, − 0.02). Additionally, exposure to BDE-47 and BDE-99 in the middle tertile was also associated with a reduction in birth weight z-scores (β = − 0.26, 95% CI = -0.48, − 0.04; β = − 0.25, 95% CI = -0.47, − 0.04, respectively) compared to those in the lowest tertile of exposure. No consistent associations were observed between increasing PFAS concentrations and gestational age or birth weight z-scores. Discussion Among a diverse group of pregnant women in the San Francisco Bay Area, we found non-linear associations between prenatal exposure to PBDEs during the second trimester of pregnancy and birth weight z-scores. However, most PFAS congeners were not associated with adverse birth outcomes. PFAS and PBDE concentrations were lower in our cohort relative to other studies. Future research should assess the effects of emerging and persistent PFAS and PBDEs on birth outcomes, as some congeners are being phased out and replaced by chemically similar structures.

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Section: Discussionmentioning

confidence: 99%

Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco

et al. 2020

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“…In some cases, exposure to PFAS did not produce any change in enzymatic activity, as in Japanese medaka after treatment with PFOA [322], in Arctic kittiwakes (Rissa sp.) that accumulate PFAS from the environment [325], or in chicken experimentally exposed to PFOS [319].…”

Section: Biochemical Datamentioning

confidence: 99%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders, and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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“…In some cases, exposure to PFAS did not produce any change in enzymatic activity, as in Japanese medaka after treatment with PFOA [319], in Arctic kittiwakes (Rissa sp.) that accumulate PFAS from the environment [322], or in chicken experimentally exposed to PFOS [316].…”

Section: Biochemical Datamentioning

confidence: 99%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato¹,

Corrà²,

Belli̇o³

et al. 2020

Preprint

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to longer perfluoroalkyl acids

Cited by 59 publications

References 59 publications

Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco

Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

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