Higher prevalence of human papillomavirus infection in migrant women from Latin America in Spain

González, Cristina; Ortiz, Marta; Canals, Josefa; Muñoz, Lourdes Gaitán; Jarrin, I.; Hera, Manoli García de la; García-Sáiz, Alfredo; Amo, Julia del

doi:10.1136/sti.2005.016774

Cited by 34 publications

(27 citation statements)

References 10 publications

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“…High prevalence in CSW in Spain had been previously described, both in Spanish (44) and in migrant CSW individuals (9). The rate of oncogenic HPV prevalence in the general population for Spanish women agrees with data previously published in Spain (12,20) and are similar to those of others conducted in European countries, such as Italy, with rates of prevalence of between 6.6 and 7.1% (10,33).…”

Section: Discussionsupporting

confidence: 79%

Oncogenic Human Papillomavirus (HPV) Type Distribution and HPV Type 16 E6 Variants in Two Spanish Population Groups with Different Levels of HPV Infection Risk

et al. 2006

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The aim of this study is to determine oncogenic human papillomavirus (HPV) types and HPV type 16 (HPV16) variant distribution in two Spanish population groups, commercial sex workers and imprisoned women (CSW/IPW) and the general population. A multicenter cross-sectional study of 1,889 women from five clinical settings in two Spanish cities was conducted from May to November 2004. Oncogenic HPV infection was tested by an Hybrid Capture II (HC2) test, and positive samples were genotyped by direct sequencing using three different primer sets in L1 (MY09/11 and GP5؉/GP6؉) and E6/E7. HPV16 variants were identified by sequencing the E6, E2, and L1 regions. Four hundred twenty-five samples were positive for the HC2 test, 31.5% from CSW/IPW and 10.7% from the general population. HPV16 was the most frequent type. Distinct profiles of oncogenic HPV type prevalence were observed across the two populations. In order of decreasing frequency, HPV types 16, 31, 58, 66, 56, and 18 were most frequent in CSW/IPW women, and types 16, 31, 52, 68, 51, and 53 were most frequent in the general population. We analyzed HPV16 intratype variants, and a large majority (78.7%) belonged to the European lineage. AA variants were detected in 16.0% of cases. African variants belonging to classes Af1 (4.0%) and Af2 (1.3%) were detected. Different HPV types and HPV16 intratype variants are involved in oncogenic HPV infections in our population. These results suggest that HPV type distribution differs in CSW/IPW women and in the general population, although further analysis is necessary.Different epidemiological studies reveal that human papillomavirus (HPV) prevalence depends largely on age and sexual practices and that it shows major differences across geographic areas. HPV prevalence has been described to be higher in Latin America and sub-Saharan Africa and lower in Asia and Europe (12,15,17,30,32,35,40,43). More than 100 types of HPV have been identified to date, of which at least 42 are associated with infections of the genital tract (42). Different genotype prevalence profiles have also been observed in different geographic areas (8). Vaccines directed against HPV type 16 (HPV16) and HPV18, present in approximately 70% of cervical cancers worldwide, are currently under evaluation and have shown impressive reductions of 90% in the incidence of HPV infection in the case of types 16 and 18 (16, 18, 22, 27, 45). The preliminary data suggest that bivalent HPV16 and HPV18 vaccine may also protect against HPV16-related types (31, 33, 35, 52, and 58) and HPV18-related types (39, 45, 59, 68, and 85) (G. Dubin, 22nd International Papillomavirus Conference and Clinical Workshop 2005, Oral Communication F-03, 2005). In order to design and evaluate the health impact of HPV infections and the potential benefits of the implementation of future vaccines, it is necessary to know the distribution of oncogenic HPV types in different geographic regions and in different populations (29).In Spain, which has one of the lowest rates of cervical cancer worldwid...

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Section: Discussionsupporting

confidence: 79%

Oncogenic Human Papillomavirus (HPV) Type Distribution and HPV Type 16 E6 Variants in Two Spanish Population Groups with Different Levels of HPV Infection Risk

et al. 2006

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“…14 This imbalance is further illustrated by recent literature indicating that women who had immigrated from Colombia to Spain were found to have a 27% prevalence of high-risk HPV types, compared to 8% of Spanish women living in the same region in Spain. 15 Furthermore, case-control studies of cervical cancer conducted in Brazil, Colombia, Paraguay and Peru have shown that HPV 16 and 18 are responsible for 65% of cervical squamous cell carcinoma and 84% of cervical adenocarcinomas in the countries listed above. 16,17 Genital warts constitute a separate, yet not unimportant issue for public health systems in Latin America.…”

mentioning

confidence: 99%

Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) L1 virus‐like‐particle vaccine in Latin American women

Pérez¹,

Lazcano‐Ponce

Hernández-Ávila

et al. 2007

Intl Journal of Cancer

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The prevalence of HPV infection in Latin America is among the highest in the world. A quadrivalent (types 6/11/16/18) human papillomavirus L1 virus-like-particle vaccine has been shown to be 95-100% effective in preventing HPV 6/11/16/18-related cervical and genital disease in women na€ ıve to vaccine HPV types. A total of 6,004 female subjects aged 9-24 were recruited from Brazil, Mexico, Colombia, Costa Rica, Guatemala and Peru. Subjects were randomized to immunization with intramuscular (deltoid) injections of HPV vaccine or placebo at enrollment (day 1), month 2 and month 6. Among vaccinated subjects in the per-protocol population from Latin America, quadrivalent HPV vaccine was 92.8 and 100% effective in preventing cervical intraepithelial neoplasia and external genital lesions related to vaccine HPV types, respectively. These data support vaccination of adolescents and young adults in the region, which is expected to greatly reduce the burden of cervical and genital cancers, precancers and genital warts. ' 2007 Wiley-Liss, Inc.Key words: HPV; cervical cancer; vaccine Infection with human papillomavirus (HPV) is considered to be an obligate step in the development of cervical cancer. 1 Human papillomavirus DNA has been isolated from more than 99% of all cases of cervical cancer. 1 Of the 200 distinct HPV genotypes that have been identified to date, 40 are known to be associated with genital infection, and about 30 types have been isolated from women with cervical cancer. 2 High-risk HPV types include HPV 16 and 18, and it is these types which are responsible for the majority of cervical cancers. 2 HPV types 6 and 11 can lead to anogenital condylomata acuminata (genital warts) 3 ; a potentially significant medical problem.The incidence of cervical cancer in the Latin American region is among the highest in the world 4 (33.5 cases per 100,000); even higher than other developing regions and countries such as subSaharan Africa (31.0 cases per 100,000) and South central and Southeast Asia (18.3 cases per 100,000). 5 The highest incidence rates are observed in Haiti (87 per 100,000), Bolivia (55 per 100,000), Peru (48 per 100,000) and Nicaragua (47 per 100,000), and the lowest rates are reported from Argentina (23 per 100,000) and Uruguay (19 per 100,000). 6 Each year near 493,000 new cases of invasive cancer of the uterine cervix are diagnosed; 83% of which ( 409,000 cases) occur in developing countries and 18% ( 86,000 cases) specifically in Latin America (Central America, South America and the Caribbean). 7 Acquisition of HPV infection starts with the onset of sexual activity and can be as high as 42.5% after 4 years of follow-up as was observed in a cohort of Colombian women between 15 and 19 years of age. 8 The prevalence of HPV infection in women with normal cervical cytology in Latin America has been reported to range from 14.5 to 16.6%. Literature suggests a prevalence of HPV of 14.5% in Morelos, Mexico, 9 14.8% in Bogota, Colombia, 10 14.0% in Santiago, Chile, 11 16.6% in Concordia, Argentina 12 and 14%...

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“…In this study, HPV-51 (7.8%), -52 (5.2%) and -66 (2.6%) were detected. These viral types appear to be common in the Spanish population [6,18,[35][36][37][38], and these HPV specific-genotypes were also detected in studies around the world. The proportions detected in these studies are diverse, being as high as 17.5%, 12.0%, and 8.1% respectively [35], while in other study [38] found similar rates to those of our study: 8.0%, 3.8%, and 7.1%, respectively.…”

Section: Discussionmentioning

confidence: 95%

“…In Spain, crude prevalence rates for HPV infection in small, specific populations or in limited geographical areas have been previously reported to range from 3% to 17% [17][18][19][20]. In a study to provide specific information for Spain in 1,043 histologically confirmed invasive cervical cancer cases from six regions, 904 of these cases (89.1%) were HPV DNA positive [5].…”

Section: Discussionmentioning

confidence: 99%

“…Very low proportions have also been detected, such as 1.6%, 1.8%, and 1.2%, respectively [6], and HPV-51 (0.75%), HPV-52 (2.25%) and HPV-66 (0.19%) [10]. Finally, considering the study which was estimated the prevalence of HR-HPV in Latin American immigrants in Spain finding a high prevalence of HPV51 (13.0%) and HPV66 (27.0%) [18], and that Valencia is a cosmopolitan city, with a large population of immigrants, it is also important to take these findings into account when designing future preventive strategies [10]. These types of HPV are of interest after Fife et al [39] suggested that those viruses might cooperate with HPH16 in the development of cancer.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Méndez¹

2013

SOJ Microbiol Infect Dis

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BackgroundCervical cancer is the second most common cancer in women worldwide and the most common cause of mortality in underdeveloped and developing countries [1,2]. Persistent infection with certain oncogenic high-risk (HR) types of Human Papillomavirus (HPV) is the required factor for the development of invasive cervical cancer and precursor lesions [3][4][5][6].Overall, the prevalence and distribution of HPV infection in cervical lesions has been determined in many geographical regions of the world, this can vary depending on several factors including epidemiological differences in the populations studied and the methodology used for molecular detection and typing of HPV DNA [7]. Over 120 types of HPV have been classified as either low (LR-HPV) or high risk (HR-HPV), according to their oncogenic potential [8,9]. Within the high-risk genotypes, HPV types 16 and HPV 18 are most often associated with cancer and squamous intraepithelial lesion [5,6,10,11,12]. Nevertheless, the risk of neoplasia for other types of HPV as well as for multiple HPV infection has not yet been established.Because current strategies for the prevention of cervical cancer and their precancerous lesions are based on the HPV genotyping [13] and prophylactic vaccines [14][15][16], it seems necessary to determine the types of HPV most commonly associated with malignant cell transformation in different geographical areas in order to establish effective preventive measures according to the epidemiology of the population. This study was to know the prevalence and distribution of cervical HPV infection in women attending routine cervical cancer screening in the Valencia region (Spain). Study designLiquid-based cytology (LBC) of cervical specimens was collected during routine screening visits, between June 20, 2011 and September 9, 2011 in the Clinical Hospital of Valencia, Spain. LBC samples were processed using the Thin Prep® 5000 processor (Madrid, Spain). For HPV detection and genotyping, we used the residual cervical sample material available from the same Thin Prep Pap test vial previously used for cytological screening. DNA was extracted from the residual materials of LBC by QIAamp® DNA mini kit (IZASA, Valencia, Spain), according to the manufacturer's instructions. HPV testing was performed by INNO-Lipa HPV genotyping Extra Reverse Hybridization Line Probe Assay kit (Innogenetics®, Barcelona, Spain), according to the manufacturer's instructions. Briefly, HPV detection and genotyping was based on PCR amplification of a 65pb fragment, within the L1 region of the HPV genome, using broad-spectrum SPF10 biotinylated primers. PCR was performed in a final AbstractBackground: Infection with human papillomavirus (HPV) has been identified as the primary cause of cervical cancer. Persistent infection with high risk-HPV is the required factor for the development of cervical cancer.

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Higher prevalence of human papillomavirus infection in migrant women from Latin America in Spain

Cited by 34 publications

References 10 publications

Oncogenic Human Papillomavirus (HPV) Type Distribution and HPV Type 16 E6 Variants in Two Spanish Population Groups with Different Levels of HPV Infection Risk

Oncogenic Human Papillomavirus (HPV) Type Distribution and HPV Type 16 E6 Variants in Two Spanish Population Groups with Different Levels of HPV Infection Risk

Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) L1 virus‐like‐particle vaccine in Latin American women

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

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