Higher Pro-Inflammatory Dietary Score is Associated with Higher Hyperuricemia Risk: Results from the Case-Controlled Korean Genome and Epidemiology Study_Cardiovascular Disease Association Study

Abstract

In previous studies, the elevated dietary inflammatory index (DII®) scores have been consistently associated with several chronic diseases. However, the relationship with hyperuricemia remains unknown. The aim of this study was to determine if the DII is associated with hyperuricemia risk. The study included 13,701 participants (men 5102; women 8599) in a large-scale cross-sectional study in South Korea. A validated semi-quantitative food frequency questionnaire (SQFFQ) was used to measure dietary intake, and blood samples were obtained to determine hyperuricemia. As the DII score increased, the hyperuricemia risk increased among women (OR 1.35, 95% CI 1.03–1.77, p trend = 0.02). However, no significant results were found for men. Women with lower BMI scores had higher risks of hyperuricemia with higher DII scores (OR 1.62, 95% CI 1.05–2.52, p trend = 0.03). As the DII increased, however, only women who consumed alcohol (“past or current drinkers”) had higher risks of hyperuricemia (OR 1.92, 1.22–3.02, p trend = 0.004). Among the DII components, intake of flavonoids showed a significant association with the hyperuricemia risk in women (OR 0.75, 0.59–0.96, p trend = 0.03). Our results suggest that higher intake of pro-inflammatory diet is significantly associated with higher risk of hyperuricemia among women. These results reinforce the importance of less pro-inflammatory habitual dietary patterns in lowering the risk of hyperuricemia and secondary afflictions such as cardiovascular diseases.

The Association between Dietary Inflammatory Index (DII) and Cancer Risk in Korea: A Prospective Cohort Study within the KoGES-HEXA Study

“…The subjects had been recruited from 38 health examination centers and hospitals located in urban areas of Korea, and only those willing to participate were enrolled; consequently, the number of women who consented to the study was higher than that of men; they might not be entirely representative of the Korean population. This type of screening bias occurs in many prospective cohort studies [78]. Second, cancer diagnosis was self-reported, and as such, errors in the numbers of cancer incidences might have been incurred.…”

Positive Association of Dietary Inflammatory Index with Incidence of Cardiovascular Disease: Findings from a Korean Population-Based Prospective Study

“…The information about sociodemographic characteristics, personal and family history, physical activity, physical examinations, clinical investigations, and semi-quantitative food frequency questionnaire (SQFFQ) were obtained at the baseline and follow-up examinations using a structured questionnaire [30][31][32][33]. Both continuous and categorical variables were recorded and the details can be found elsewhere [34,35]. Regularity of physical activity was determined according to whether or not subjects participated regularly in any sports to the point of sweating.…”

Anti-Inflammatory Diets and Schizophrenia

“…E-DII scores were positively correlated with the K-MMSE scores suggesting that participants classified as normal condition had relatively higher anti-inflammatory diets rather than those who were diagnosed with boundary, mild, and moderate cognitive impairment. To investigate the relationship between DII and metabolic syndrome, the analysis using Health Examinees Cohort Study data from the Korean Genome and Epidemiology Study was conducted [ 67 ]. Participants over age of 40 years were selected, and definition of Modified National Cholesterol Education Program Adult Treatment Panel III from American Heart Association and National Heart, Lung, and Blood Institute were used to diagnose metabolic syndrome.…”