Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study

Abstract

Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults

“…During OLE, no (further) change in eGFR was observed in any of the (sub)groups. The alteration of eGFR in response to a high protein diet is in line with observations by others and is thought to be an adaptive response to the protein feeding and not the development of CKD per se [31,33,34]. The observed plateau in eGFR after 13 weeks of treatment with 2 servings of WP-MND during the OLE period, supports this notion of adaptation.…”

“…The consistent high protein intake in line with recommendations, especially in participants receiving 2 servings of WP-MND throughout the entire 26-week study period (during RCT and OLE), enabled evaluation of the effect of a prolonged high protein intake on kidney function. Concerns regarding the adverse effect of a high protein diet on kidney function are related to glomerular hyperfiltration and hypertensive effects [31][32][33]. During the RCT, eGFR increased in the test vs. no change in the control group (p = 0.002).…”

Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid–Base Status and Kidney Function at Rest and during Submaximal Cycling

“…In individuals with moderate to severe renal insufficiency, a low protein intake may slow renal function decline, but the long-term impact of protein intake on kidney function in individuals with normal kidney function or mild renal insufficiency is unknown [ 20 ]. A recent paper by Møller et al [ 21 ] reported no association between ahigher protein intake and decreased kidney function in pre-diabetic older adults during a one-year intervention. In a study by Antonio et al [ 22 ], high protein intake (2.5 g/kg/day) was compared to higher intake (~3.3 g/kg/day), and it was reported that these high protein diets were not deleterious for kidney function over a one-year crossover study period.…”

Proteina Ugariko Dietak: Lagunak ala Etsaiak? Artikuluen Berrikusketa.

“…duten pertsonetan ere ez da behatu giltzurrun kalterik HP dieta hartutakoan(13). Zenbait metaanalisi ere proteinen kontsumoaren alde agertu dira: proteinen kontsumoak GGM handitzen duela adierazten du, nahiz eta entrenatu gabeko pertsonek 1,62 g/kg/egun-etik gora onura esanguratsurik ez erakutsi, ez baitute hartutako proteinak aprobetxatzeko horrenbesteko ahalmenik(16).…”