Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

Masturzo, Bianca; Martino, Daniela Di; Prefumo, Federico; Cavoretto, Paolo; Germano, Chiara; Gennarelli, Gianluca; Roletti, E.; Bottazzoli, Elisa; Fusè, F.; Ferrazzi, E.; Morano, Danila; Farina, Antonio

doi:10.1007/s00404-019-05291-w

Cited by 11 publications

(9 citation statements)

References 34 publications

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“…Literature results confirm that all of these factors may be associated with a higher risk of adverse pregnancy outcomes [30]. In our study, the percentage of women treated for infertility did not differ statistically between older and younger women, and our results for hypertension in pregnancy were adjusted for infertility treatment [31].…”

Section: Discussionsupporting

confidence: 81%

“…Table 3 shows the odds ratios of adverse pregnancy outcomes for maternal age regarding the age range of 18-24 years. This table highlights the results where the odds ratios of pregnancy outcomes increased "linearly" with maternal age (GH, GDM, and cesarean section) or increased to the plateau phase (ages [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] and then increased at the age of ≥40 (for LGA and macrosomia, and after adjustment also for SGA and LBW). The youngest age was associated with the highest odds ratios of PE and premature birth (also after adjustment).…”

Section: Effects Of Maternal Age On the Adverse Pregnancy Resultsmentioning

confidence: 87%

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The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

Lewandowska

Sajdak²,

Więckowska

et al. 2020

Nutrients

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As mothers age, the risk of adverse pregnancy outcomes may increase, but the results so far are controversial and several issues remain unknown, such as the impact of maternal weight on the effects associated with older age. In a prospective cohort of 912 Polish women with singleton pregnancies (recruited in 2015–2016), we assessed the pregnancy outcomes depending on the mother’s age (18–24, 25–29, 30–34, 35–39, and ≥40 years). Women aged ≥35 years (vs. <35 years) were assessed in terms of body mass index (BMI). Multidimensional logistic regression was used to calculate the odds ratios (with 95% confidence intervals) of the pregnancy results. The risk profiles (using the Lowess method) were applied to determine the threshold risk. We found that both the youngest and the oldest group members displayed higher adjusted odds ratios of preeclampsia (PE), intrauterine growth restriction (IUGR), and preterm birth <37th week (U-shaped risk). In the remaining cases, the age ≥40 years, compared to the youngest age 18–24 years, was associated with a higher adjusted risk of gestational hypertension (GH) (AOR = 5.76, p = 0.034), gestational diabetes mellitus GDM-1 (AOR = 7.06, p = 0.016), cesarean section (AOR = 6.97, p <0.001), and low birth weight LBW (AOR = 15.73, p = 0.033) as well as macrosomia >4000 g (AOR = 8.95, p = 0.048). We found that older age ≥35 years (vs. <35 years) was associated with higher adjusted odds ratios of all the pregnancy outcomes investigated. In obese women, these adverse older age related results were found to be more intense in GH study, as well as (though weaker) in birth <37th week study, small-for-gestational age birth weight (SGA), LBW, large-for-gestational age birth weight (LGA), and macrosomia. In overweight women, these adverse older age related results were found to be more intense in preterm birth study, as well as (though weaker) in SGA and LBW. In underweight women, adverse pregnancy outcomes related to older age were more intense in a study of cesarean section. At the same time, underweight was associated with reversal of some negative effects of older age (we found lower odds ratios of GDM-1 diabetes). The maternal threshold age above which the risk of GH, PE, GDM, caesarean section, and preterm birth increased was 33–34 years (lower than the threshold of 35 years assumed in the literature), and the threshold risk of IUGR, LBW, SGA, LGA, and macrosomia was 36–37 years. Main conclusions: Older maternal age was associated with a higher chance of all kinds of obstetric complications. Older women should particularly avoid obesity and overweight.

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Section: Discussionsupporting

confidence: 81%

Section: Effects Of Maternal Age On the Adverse Pregnancy Resultsmentioning

confidence: 87%

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

Lewandowska

Sajdak²,

Więckowska

et al. 2020

Nutrients

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“…In animal models, the fluctuation of circulating steroids could lead to a reduction in uterine vascular resistance [29]. In addition, a recent study showed that the increased age of a pregnant woman during egg donation increases the risk of PE [29]. The above discoveries seem to explain the hypothesis that older pregnant women whose lower 17 β -E affect the uterine arteries pulsatility index had a higher risk for PE.…”

Section: Summary Of Key Resultsmentioning

confidence: 98%

“…The authors of this study described this new phenomenon as increasing placental perfusion to compensate for maternal or placental dysfunction [27]. In animal models, the fluctuation of circulating steroids could lead to a reduction in uterine vascular resistance [29]. In addition, a recent study showed that the increased age of a pregnant woman during egg donation increases the risk of PE [29].…”

Section: Summary Of Key Resultsmentioning

confidence: 99%

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Pan

Wei

Wang

et al. 2020

BMC Pregnancy Childbirth

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Background Both genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population. Methods This case-control study involved 335 Han Chinese pregnant women, including 177 pregnant women with preeclampsia and 158 healthy controls. The preeclampsia group was further sub-grouped into early-onset preeclampsia (EOPE, n = 70)and late-onset preeclampsia (LOPE, n = 107. Three single nucleotide polymorphisms (SNPs), including FOXO3 (rs2232365, rs3761548), and TLR7 rs3853839 were genotyped by multiplex PCR for targeted next-generation sequencing. The χ2 test and multiple interaction effect analyses were performed to determine the association of three SNPs with serum lipid levels and thyroid function in women with preeclampsia. Results The genotype (CC vs. TT + CT) distribution of rs2232365 revealed a significant association with LOPE (P = 0.004, odds ratio = 3.525 (0.95 CI: 1.498–8.164)). No significant difference was found in the genotype and allele frequencies of rs3761548 and rs3853839 between controls and cases (P > 0.05). Moreover, the genotype CT/TT of rs2232365 was significantly correlated with increased TG/HDL levels in the LOPE group (p = 0.014). Conclusions The polymorphisms of rs2232365 are associated with the risk of LOPE and may modulate TG/HDL levels in pregnant women with LOPE.

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“…Thirty-eight studies were excluded for the following reasons: review, systematic review, meta-analysis, correspondence, or articles not reporting original data (n = 12), original articles of non-Italian study population (n = 18), original articles about screening for both PE and pregnancyinduced hypertension (n = 1), original articles about other PE screening strategies that excluded the first trimester (n = 6), and original articles not reporting data on screening performance (n = 1). Finally, nine articles were included in this review [11][12][13][14][15][16][18][19][20] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Real-world implementation and adaptation to local settings of first trimester preeclampsia screening in Italy: a systematic review

Amodeo¹,

Bonavina²,

Seidenari³

et al. 2021

Clin. Exp. Obstet. Gynecol.

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Background: Preeclampsia (PE) is a multisystem disease of pregnancy representing a major cause of maternal and perinatal morbidity and mortality. Early identification of pregnancies at risk of developing PE is crucial for implementing preventive strategies. The effectiveness of PE screening in the first trimester is widely recognized and endorsed by several guidelines, but unfortunately real-world implementation of this practice within local settings remains difficult. Methods: We performed a systematic review of the literature to understand the critical issues hampering the implementation of PE screening procedures in Italy. All studies on first trimester PE screening in the Italian population were eligible for inclusion. Key-concepts relevant for implementation of PE screening in Italy were extracted and analysed qualitatively. Results: Nine articles were selected and included. Lack of evidence concerning the topic of PE screening in Italy was shown. Major critical issues found encompassed healthcare personnel education, training of sonographers, economic coverage for biochemical markers and adjustment of algorithms based on population characteristics. Conclusions: Identification and adaptation of specific protocols to local settings and population characteristics is critical for successful implementation of early PE screening in Italy. This process has the potential to improve pregnancy outcomes and to save valuable health-care resources, particularly scarce in the COVID-19 era. There is an urgent need for research studies on specific local populations focussing on subtle details capable of maximizing PE screening uptake. This action will likely potentiate PE screening implementation reducing the burden and the cost of perinatal and maternal complications.

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Higher rate of early-onset preeclampsia in pregnancies following oocyte donation according to increasing maternal age

Cited by 11 publications

References 34 publications

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Real-world implementation and adaptation to local settings of first trimester preeclampsia screening in Italy: a systematic review

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