Higher Renal Allograft Function in Deceased-Donor Kidney Transplantation Rather Than in Living-Related Kidney Transplantation

Xiong, Ye; Jiang, Jun; Zhang, H.; Fu, Qian; Deng, Ronghai; Li, J.; Liu, L.; Yuan, Xiaopeng; He, Xiaoshun; Wang, C.

doi:10.1016/j.transproceed.2018.03.041

Cited by 3 publications

(5 citation statements)

References 22 publications

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“…In reports that span the globe, patient and graft survival rates are > 90% at 1 year and > 80% at 5 years after KT. [1–4] Infectious complications remain a common cause of mortality however, especially during the first year after KT. [5,6] In a recent study, 8.6% of kidney transplant recipients (KTRs) died within 5 years of transplantation and 53% of those deaths were due to infection, a rate that is twice that of the second most common cause of death.…”

Section: Introductionmentioning

confidence: 99%

Risk factors and etiology of repeat infection in kidney transplant recipients

Chen

et al. 2019

Medicine

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Kidney transplantation (KT) is the best therapy available for patients with end-stage renal disease, but postoperative infections are a significant cause of mortality.In this retrospective study the frequency, risk factors, causative pathogens, and clinical manifestations of infection in KT recipients from Beijing Chao-Yang Hospital, Capital Medical University were investigated. Ninety-seven KT recipients who were hospitalized with infection between January 2010 and December 2016 were included. Clinical characteristics, surgery details, laboratory results, and etiology were compared in patients who developed single infection and patients who developed repeated infection (2 or more) after KT.A total of 161 infections were adequately documented in a total of 97 patients, of which 57 patients (58.8%) had 1 infection, 24 (24.7%) had 2, 11 (11.3%) had 3; 3 (3.1%) had 4, and 2 (2.1%) had 5 or more. The most common infection site was the urinary tract (90 infections; 56%), both overall and in the repeated infection group. The most frequently isolated pathogen was Pseudomonas aeruginosa. In the repeated infection patients, in most cases of P. aeruginosa infection (54%) it was cultured from urine. For first infections, a time between KT and infection of ≤ 21 days (area under receiver operating characteristic curve [AUC] 0.636) and a tacrolimus level ≥ 8 ng/mL (AUC 0.663) independently predicted repeat infection. The combination of these two predictive factors yielded an AUC of 0.716, which did not differ statistically significantly from either predictor alone.With regard to first infections after KT, a time between KT and infection of ≤ 21 days, and a tacrolimus level ≥ 8 ng/mL each independently predicted repeated infection in KT recipients.

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Section: Introductionmentioning

confidence: 99%

Risk factors and etiology of repeat infection in kidney transplant recipients

Chen

et al. 2019

Medicine

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“…Dr Wang's group from China published 2 large, retrospective, single-center studies based on approximately 1100 patients who underwent either LRKT or DDKT from 2004 to 2015. 33,34 The group found better 1-, 3-, and 5-year graft survival after LRKT (98.8%, 98.5%, and 97.2%, respectively) compared with DDKT (94.9%, 91.3%, and 91.3%). 33 DDKT had a higher rate of DGF (20.6% vs 2.6%, P < .001).…”

Section: Discussionmentioning

confidence: 89%

“…33,34 The group found better 1-, 3-, and 5-year graft survival after LRKT (98.8%, 98.5%, and 97.2%, respectively) compared with DDKT (94.9%, 91.3%, and 91.3%). 33 DDKT had a higher rate of DGF (20.6% vs 2.6%, P < .001). Interestingly, at 1, 2, and 3 years after transplantation, graft function (based on estimated glomerular filtration rate and serum Cr) was better in the DDKT cohort compared with the LRKT cohort, and the authors speculated that this could be related to older grafts from living donors (47.5 ± 11 vs 31.3 ± 14 years old, P < .001).…”

Section: Discussionmentioning

confidence: 89%

“…34 Of note in this cohort, patients who received LRKT were younger (33 vs 44 years old), healthier (less diabetes, shorter duration of dialysis), and received organs with closer HLA matches than DDKT recipients. 33,34 Donor Management. As the waitlist for kidney transplants grows, interest in expanding the pool of available organs increases.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, at 1, 2, and 3 years after transplantation, graft function (based on estimated glomerular filtration rate and serum Cr) was better in the DDKT cohort compared with the LRKT cohort, and the authors speculated that this could be related to older grafts from living donors (47.5 ± 11 vs 31.3 ± 14 years old, P < .001). 33 Risk factors for graft survival in LRKT were pretransplant dialysis duration (HR = 1.023 per month; P = .046), DGF (HR = 5.785; P = .02), and acute rejection (HR = 2.706; P = .04), whereas risk factors for graft survival in DDKT were recipient age (HR = 1.066 per year; P = .004), recipient history of diabetes (HR = 3.011; P = .03), pretransplant positive PRAs (HR = 3.353; P = .02), and donor HTN (HR = 2.660; P = .046). 34 Of note in this cohort, patients who received LRKT were younger (33 vs 44 years old), healthier (less diabetes, shorter duration of dialysis), and received organs with closer HLA matches than DDKT recipients.…”

Section: Kidney Transplantationmentioning

confidence: 99%

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Abdominal Organ Transplantation: Noteworthy Literature in 2018

Zerillo

Schlichting

Sakai

2019

Semin Cardiothorac Vasc Anesth

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A PubMed search revealed 1382 articles on pancreatic transplantation, 781 on intestinal transplantation, more than 7200 on kidney transplantation, and more than 5500 on liver transplantation published between January 1, 2018, and December 31, 2018. After narrowing the list down to human studies, 436 pancreatic, 302 intestinal, 1920 liver, and more than 2000 kidney transplantation studies were screened for inclusion in this review.

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