Higher risk of venous thrombosis associated with drospirenone-containing oral contraceptives: a population-based cohort study

Gronich, Naomi; Lavi, Idit; Rennert, Gad

doi:10.1503/cmaj.110463

Cited by 119 publications

(89 citation statements)

References 28 publications

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“…The incidence of venous thromboembolism was 1.5-fold increased among women with PCOS not taking oral contraceptives compared with controls and twofold increased among women with PCOS who were taking combined oral contraceptives compared with controls (68). Furthermore, the higher generation of oral contraceptives may further increase the coagulability as fourth-generation oral contraceptives containing drospirenone had the highest thromboembolic risk (69). In our register-based study, five of six patients with thrombosis had been on oral contraceptives (7).…”

Section: Cardiometabolic Disease In Pcosmentioning

confidence: 65%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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Section: Cardiometabolic Disease In Pcosmentioning

confidence: 65%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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“…• Drosperinone (DRSP)-containing COCs increase the risk of deep vein thrombosis and pulmonary embolism: however, it is not associated with increased risk of transient ischemic attack or cerebrovascular attack compared with COCs containing second and third-generation progestins (Gronich et al, 2011). …”

Section: Supplementary Tablementioning

confidence: 99%

Synthetic Hormones and Clot Formation

2016

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Combined oral contraceptives (COCs), colloquially referred to as "the pill," have been regarded as a medical breakthrough, as they have improved the lives of countless women, from simplifying family planning to the treatment of acne, endometriosis, polycystic ovarian syndrome, and dysmenorrhea. Unfortunately, COC usage has been associated with an increased occurrence of venous thrombosis and therefore a systemic hypercoagulable state in susceptible females. Here we discuss the health risks of COC usage and use viscoelastic and morphological techniques to investigate the effect of different COC constituents on clot formation, particularly fibrin network packaging and whole blood viscoelasticity. Viscoelastic properties of whole blood showed gender-specific changes while morphological alterations were person-specific, regardless of gender. Using scanning electron microscopy and thromboelastography provides great insight regarding fibrin packaging and the development of a hypercoagulable state in high-risk individuals. We proposed a three-step approach where (1) an individual's coagulation profile baseline is determined, after which (2) the "ideal" combination of constituents is prescribed, and (3) the coagulation profile of the individual is monitored to assess possible risk of thrombosis. Only in following such an individualized patient-oriented approach will we be able to avoid the many health issues due to COC usage in susceptible females.

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“…В израильском популяционном когортном исследовании прием ОК, содержащих дроспиренон, не сопровождался повы-шением риска ТИА и инсульта [489].…”

Section: беременностьunclassified

2013 Esh/Esc Guidelines for the Management of Arterial Hypertension

Mancia

Fagard²,

Redón³

et al. 2014

Russ J Cardiol

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Авторы/члены рабочей группы: Giuseppe Mancia (сопредседатель; италия)*, Robert Fagard (сопредседатель; бельгия)*, Krzysztof Narkiewicz (координатор секции, Польша), Josep Redón (координатор секции; испания), Alberto Zanchetti (координатор секции, италия), Michael Böhm

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Higher risk of venous thrombosis associated with drospirenone-containing oral contraceptives: a population-based cohort study

Cited by 119 publications

References 28 publications

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Synthetic Hormones and Clot Formation

2013 Esh/Esc Guidelines for the Management of Arterial Hypertension

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