Higher salivary expression of S100A12 in patients with ulcerative colitis and chronic periodontitis

Figueredo, Carlos Marcelo; Nunes, Jéssica Gomes Rodrigues; Mello‐Neto, João Martins de; Carvalho, Ana Teresa Pugas; Ipe, Deepak S.

doi:10.1097/meg.0000000000001771

Cited by 5 publications

(8 citation statements)

References 6 publications

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“…After the elimination of duplicates and analyses of the titles and abstracts, 85 full texts were analyzed (Figure 1). Finally, six articles were included in the qualitative analysis [27][28][29][30][31][32]. Supplementary Material Table S1 depicts the excluded studies.…”

Section: Resultsmentioning

confidence: 99%

“…In the remaining 99 patients, 89 had periodontal disease only, and 10 were healthy controls. The studies assessed immunological changes in subjects in GCF [27][28][29], serum [27,28], saliva [30], gingival biopsies [31,32] and intestinal biopsies [31,32]. Different methods of analysis (three studies used ELISA assay while Luminex assay and radioimmunoassay were used by two and one study, respectively) were used to evaluate the role of cellular immune response in the presence of both IBD and periodontitis.…”

Section: Background Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Different methods of analysis (three studies used ELISA assay while Luminex assay and radioimmunoassay were used by two and one study, respectively) were used to evaluate the role of cellular immune response in the presence of both IBD and periodontitis. Analysis of the geographic distribution revealed that four studies were carried out in Brazil [28,[30][31][32] and one each in the United States [27] and Germany [29]. None of the studies performed a power calculation.…”

Section: Background Characteristics Of the Included Studiesmentioning

confidence: 99%

“…None of the studies performed a power calculation. Four studies identified that the coexistence of IBD and periodontal disease is associated with higher levels of pro-inflammatory molecules when compared to patients with one or the other [27][28][29][30]. One study showed that the activity of IBD increases the levels of IL-4, IL-10 and IL-21in the periodontal tissue [31].…”

Section: Background Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Only one study with a high risk of bias evaluated immunological changes in the saliva of patients having both diseases [30]. Higher expression of S100A12 was found in patients with UC with chronic periodontitis when compared to non-IBD and CD patients also with periodontitis [30].…”

Section: • Salivary Changes In Patients With Ibd and Periodontitismentioning

confidence: 99%

See 4 more Smart Citations

Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review

Mello‐Neto

Nunes

Tadakamadla

et al. 2021

IJERPH

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This systematic review assessed studies that evaluated the immunological traits of patients with both inflammatory bowel disease (IBD) and periodontal disease. An electronic search for literature was conducted on PubMed, Embase, Scopus, Cochrane and Web of Science. Studies that evaluated the immunological response in patients with IBD and periodontal disease were considered eligible for inclusion. A total of 6 cross-sectional studies of 275 patients were included. Immunological analyses were performed in gingival crevicular fluid, saliva, serum, intestinal and gingival biopsies. Four studies identified that the presence of IBD and periodontal disease was associated with higher levels of prostaglandin E2, aMMP8, IL-18 and S100A12, respectively, when compared to patients without the coexistence of both diseases. Furthermore, another study identified higher aMMP-8 levels with increasing severity of periodontitis in Crohn’s disease patients. The quality of overall evidence ranged from high to low due to the observational nature of contributing studies. The coexistence of IBD and periodontal disease seems to be associated with a more responsive inflammatory reaction compared with individuals having one or the other. More randomized controlled studies evaluating the coexistence of IBD and periodontitis are required to better explore the immunological interplay between them.

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Section: Resultsmentioning

confidence: 99%

Section: Background Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Background Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Background Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: • Salivary Changes In Patients With Ibd and Periodontitismentioning

confidence: 99%

See 3 more Smart Citations

Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review

Mello‐Neto

Nunes

Tadakamadla

et al. 2021

IJERPH

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S100A12 protein as a porcine health status biomarker when quantified in saliva samples

Gutiérrez,

Matas-Quintanilla,

Piñeiro

et al. 2024

The Veterinary Journal

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Unravelling the Oral–Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective

Tanwar,

Gnanasekaran,

Allison

et al. 2024

Journal of Crohn's and Colitis

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As the opposite ends of the orodigestive tract, the oral cavity and the intestine share anatomical, microbial, and immunological ties that have bidirectional health implications. A growing body of evidence suggests an interconnection between oral pathologies and Inflammatory Bowel Disease (IBD), implying a shift from the traditional concept of independent diseases to a complex, reciprocal cycle. This review outlines the evidence supporting an "Oral-Gut" axis, marked by a higher prevalence of periodontitis and other oral conditions in IBD patients and vice versa. We present an in-depth examination of the interconnection between oral pathologies and IBD, highlighting the shared microbiological and immunological pathways, and proposing a “multi-hit” hypothesis in the pathogenesis of periodontitis-mediated intestinal inflammation. Furthermore, the review underscores the critical need for a collaborative approach between dentists and gastroenterologists to provide holistic oral-systemic healthcare.

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Higher salivary expression of S100A12 in patients with ulcerative colitis and chronic periodontitis

Cited by 5 publications

References 6 publications

Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review

Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review

S100A12 protein as a porcine health status biomarker when quantified in saliva samples

Unravelling the Oral–Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective

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