Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly

Liu, Miaomiao; Tang, Jingping; Zeng, Jing; He, Yao

doi:10.1016/j.jdiacomp.2017.08.015

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…In total, we included 54 articles based on 48 unique observational cohort studies. [5,6,8,9,10,11,12,15,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,…”

Section: Study Identification and Selectionmentioning

confidence: 99%

“…Figure 2 provides a summary of meta-analyses of the associations between serum albumin and risk of the primary and secondary outcomes evaluated. In meta-analysis of 9 studies, [8,11,12,15,54,66,68,73] comparing the top versus bottom third of serum albumin levels, the pooled fully-adjusted RR (95% CI) of type 2 diabetes was 1.03 (0.86-1.22) (Figure 3). There was significant heterogeneity between contributing studies (I 2 =68%; 95% CI 33, 85%; p for heterogeneity<0.001), which seemed to be partly explained by the sample size (p for meta-regression=0.04).…”

Section: Serum Albumin and Risk Of Primary Outcomesmentioning

confidence: 99%

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Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants

Seidu

Kunutsor

Khunti

2020

Scandinavian Cardiovascular Journal

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Objectives. A general body of evidence suggests that low serum albumin might be associated with increased risk of adverse cardiometabolic outcomes, but findings are divergent. We aimed to quantify associations of serum albumin with the risk of type 2 diabetes (T2D), cardiovascular disease (CVD), all-cause mortality, and other adverse outcomes using a systematic review and meta-analyses of published observational cohort studies. Design. MEDLINE, Embase, Web of Science, and manual search of relevant bibliographies were systematically searched to January 2020. Relative risks (RRs) with 95% confidence intervals (CIs) comparing top versus bottom thirds of serum albumin levels were pooled. Results. Fifty-four articles based on 48 unique observational cohort studies comprising of 1,492,237 participants were eligible. Multivariable adjusted RRs (95% CIs) comparing the top vs bottom third of serum albumin levels were

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Section: Study Identification and Selectionmentioning

confidence: 99%

Section: Serum Albumin and Risk Of Primary Outcomesmentioning

confidence: 99%

Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants

Seidu

Kunutsor

Khunti

2020

Scandinavian Cardiovascular Journal

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“…Moreover, the authors adjusted more biochemical parameters in the present study, including ALB, GLB, DBIL, and BUN. Evidence showed that those parameters were associated with Pre-DM [29][30][31][32]. In testing the robustness of the results by a set of sensitivity analyses (target independent variable transformation, subgroup analysis and using a GAM to insert the continuity covariate into the equation as a curve), the stronger positive association was found in female and the population with 30 years < age < 40 years, 18.5 kg/m 2 ≤ BMI < 24 kg/ m 2 , and ALT ≤ 40U/L, which would be the spotlight of attention in clinic.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-to-high-density lipoprotein cholesterol ratio and prediabetes: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol

et al. 2022

J Transl Med

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Background Evidence about the relationship between triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and prediabetes (Pre-DM) in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol (LDL-c) is limited. Therefore, the present study was undertaken to explore the link of the TG/HDL-C ratio on Pre-DM among non-obese Chinese population with a normal range of LDL-c. Methods This study was a cross-sectional study that enrolled 153163 non-obese individuals with a normal range of low-density lipoprotein cholesterol in a Chinese hospital from January 2010 to December 2014. Logistic regression model, generalized additive model (GAM), smooth curve fitting and a series of sensitivity analyses was used to evaluate the association between TG/HDL-C ratio and Pre-DM. Result The prevalence of Pre-DM was 9.77%.The median TG/HDL-C ratio was 0.671 (interquartile range, 0.468–1.010). After adjusting covariates, the results showed that TG/HDL-C ratio was positively associated with Pre-DM ((OR = 1.185, 95%CI 1.145–1.226). In addition, the TG/HDL-C ratio level has a non-linear relationship with the incidence of Pre-DM, in which the inflection point was 1.617. The effect sizes (OR) on the left and right sides of the inflection point were 1.312 (95%CI 1.242–1.386) and 0.980 (95%CI 0.898–1.070), respectively. And the sensitive analysis demonstrated the robustness of the results. Subgroup analysis showed a stronger association between TG/HDL-C ratio and Pre-DM in females and the population with 30 years < age < 40 years, 18.5 kg/m2 < body mass index < 24 kg/m2, and ALT < 40U/L. Conclusion This study demonstrates a positive and non-linear relationship between TG/HDL-C ratio and Pre-DM in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol. TG/HDL-C ratio is strongly related to Pre-DM when TG/HDL-C ratio is less than 1.617. It makes sense to reduce the TG/HDL-C ratio level below the inflection point from a treatment perspective.

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“…ALB is a useful marker of nutrition and general health status, and it has been shown that ALB concentration is associated with metabolic syndromes, diabetes, coronary heart disease, all-cause mortality and IR (35)(36)(37). T2D is also characterized by systemic low-grade inflammation, which promotes the development of IR (38).…”

Section: Discussionmentioning

confidence: 99%

<em>In silico</em> prediction and validation of potential therapeutic genes in pancreatic β‑cells associated with type 2 diabetes

Zhou¹,

Mou²,

Liu³

et al. 2020

Exp Ther Med

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Diabetes mellitus is becoming a major health burden worldwide. Pancreatic β-cell death is a characteristic of type 2 diabetes (T2D), but the underlying mechanisms of pancreatic β-cell death remain unknown. Therefore, the aim of the present study was to identify potential targets in the pancreatic islet of T2D. The GSE20966 dataset was obtained from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were identified by using the GEO2R tool. The Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes Pathway enrichment analysis of DEGs were further assessed using the Database for Annotation, Visualization and Integrated Discovery. Furthermore, protein-protein interaction (PPI) networks were constructed for the up-and downregulated genes using STRING databases and were then visualized with Cytoscape. The body weight, fasting blood glucose (FBG), pancreatic index and biochemistry parameters were measured in db/db mice. Moreover, the morphology of the pancreas was detected by hematoxylin and eosin staining, and hub genes were assessed using reverse transcription-quantitative PCR (RT-qPCR) and western blot analysis. In total, 570 DEGs were screened, including 376 upregulated and 194 downregulated genes, which were associated with 'complement activation, classical pathway', 'proteolysis', 'complement activation' and 'pancreatic secretion pathway'. It was found that the body weight, FBG, alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, blood urea nitrogen, creatinine, fasting serum insulin, glucagon and low-density lipoprotein cholesterol levels were significantly higher in db/db mice, while high-density lipoprotein cholesterol levels and the pancreatic index were significantly decreased. Furthermore, albumin, interleukin-8, CD44, CC motif chemokine ligand 2, hepatocyte growth factor, cystic fibrosis transmembrane conductance regulator, histone cluster 1 H2B family member n, mitogen-activated protein kinase 11 and neurotrophic receptor tyrosine kinase 2 were identified as hub genes in PPI network. RT-qPCR and western blotting results demonstrated the same expression trend in hub genes as found by the bioinformatics analysis. Therefore, the present study identified a series of hub genes involved in the progression of pancreatic β-cell, which may help to develop effective therapeutic strategy for T2D.

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Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly

Cited by 8 publications

References 21 publications

Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants

Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants

Association between triglyceride-to-high-density lipoprotein cholesterol ratio and prediabetes: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol

<em>In silico</em> prediction and validation of potential therapeutic genes in pancreatic β‑cells associated with type 2 diabetes

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Higher serum albumin was related with diabetes incidence and the impact of BMI changes: Based on cohort study of 18,384 Chinese male elderly

Cited by 8 publications

References 21 publications

Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants

Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants

Association between triglyceride-to-high-density lipoprotein cholesterol ratio and prediabetes: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol

<em>In&nbsp;silico</em> prediction and validation of potential therapeutic genes in pancreatic &beta;‑cells associated with type 2 diabetes

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<em>In silico</em> prediction and validation of potential therapeutic genes in pancreatic β‑cells associated with type 2 diabetes