Higher serum triglyceride levels are associated with Parkinson's disease mild cognitive impairment

Huang, Xinxin; Ng, Samuel Yong‐Ern; Chia, Nicole Shuang Yu; Acharyya, Sanchalika; Setiawan, Fiona; Lu, Zejun; Tan, Yi Jayne; Ng, Ebonne Yulin; Wen, Ming‐Ching; Ng, Adeline Su Lyn; Tay, Kay Yaw; Au, Wing Lok; Tan, Eng‐King; Tan, Louis C.S.

doi:10.1002/mds.27521

Cited by 21 publications

(18 citation statements)

References 7 publications

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“…Several biomarkers have been suggested, including biofluids, peripheral tissues, genetic, and imaging, to monitor the onset and progression of the clinical manifestations of PD. Lower levels of cerebrospinal fluid (CSF) α-synuclein and amyloid-β, and increased level of blood triglycerides have been reported to be associated with the clinical manifestations of PD 21,22 . Although controversial, the presence of aggregated α-synuclein in the skin and gastrointestinal tract has been reported to be a prodromal finding for the development of PD 23 .…”

Section: Discussionmentioning

confidence: 99%

Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson’s disease

Sung

Choi

Kim

et al. 2019

Sci Rep

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We investigated the association between retinal changes measured using optical coherence tomography (OCT) and diverse clinical grading scales in patients with Parkinson’s disease (PD). Seventy-four eyes of 74 patients with de novo PD and 53 eyes of age-matched control subjects were included. The thickness of the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) were measured. We analyzed the correlations between the clinical PD grading scales and OCT parameters, and between the OCT parameters and volumetric data in the cerebral cortical and subcortical structures. The area under the receiver operating characteristic curve (AUC) was calculated for diagnosing cognitive impairment in patients with PD. Statistically significant reductions in the thickness of average, temporal, and inferior pRNFL and overall mGCIPL were observed in patients with PD. The Montreal Cognitive Assessment score was significantly associated with mGCIPL thinning. The AUC of the mGCIPL parameters for diagnosing cognitive impairment in patients with PD ranged from 0.651 to 0.760. Moreover, thinning of the mGCIPL was significantly associated with the volumetric parameters of associated brain structures. Our findings highlight the clinical implications of OCT measurements as a potential biomarker for early detection of cognitive impairment in patients with PD.

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Section: Discussionmentioning

confidence: 99%

Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson’s disease

Sung

Choi

Kim

et al. 2019

Sci Rep

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“…About 25% of TC is distributed in brain and nerve tissues, maintaining the normal structures and functions of cells. TC metabolic disorders may be associated with neurological diseases such as PD and Alzheimer's disease . At present, TC, TG, HDL‐C, LDL‐C, apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), and lipoprotein a (Lpa) are primarily monitored in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…TC metabolic disorders may be associated with neurological diseases such as PD and Alzheimer's disease. 3 At present, TC, TG, HDL-C, LDL-C, apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), and lipoprotein a (Lpa) are primarily monitored in clinical practice. Apo A1 is the main apolipoprotein of HDL-C, and Apo B is the main structural protein of LDL-C and very low-density lipoprotein cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Correlations between blood lipid, serum cystatin C, and homocysteine levels in patients with Parkinson's disease

Zhu

et al. 2019

Psychogeriatrics

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Aim The aim was too study the correlations between blood lipid, serum cystatin C (Cys C) and homocysteine (Hcy) levels in patients with Parkinson's disease (PD). Methods A total of 322 PD patients and 214 healthy subjects were selected as case and control groups, respectively. The risk factors were explored by logistic regression analysis. The case group was subtyped according to main motor symptoms and age of onset. The correlations of significantly different indices with age, duration of disease, and equivalent dose of levodopa were studied by Spearman's correlation analysis. Receiver operating characteristic curves were plotted to analyze diagnostic values. Results Compared to the control group, the PD group had lower serum total cholesterol, triglyceride, and apolipoprotein B (Apo B) levels and higher high‐density lipoprotein cholesterol (HDL‐C), Hcy, and Cys C levels (P < 0.05). Decreased Apo B level and increased HDL‐C and Hcy levels were independent risk factors (P < 0.05). The Cys C level of early‐onset patients was lower than of late‐onset patients (P < 0.05). Hcy (r = 0.198, P < 0.05) and Cys C (r = 0.281, P < 0.05) levels were positively correlated with age. Triglyceride level was negatively correlated with age (r = −0.202, P < 0.05) and disease duration (r = −0.198, P < 0.05). Unified Parkinson's Disease Rating Scale III score was positively correlated with disease duration (r = 0.435, P < 0.05) and equivalent dose of levodopa (r = 0.423, P < 0.05). The areas under the curve for Apo B, HDL‐C, and Hcy levels were 0.341, 0.588, and 0.643, respectively (P < 0.05). The combination of Apo B, HDL‐C, and Hcy levels showed high diagnostic value, with a sensitivity of 76.4% and specificity of 69.5%. Conclusions Low serum levels of total cholesterol, triglyceride, and Apo B, and high levels of HDL‐C, Hcy, and Cys C may be correlated with PD onset and progression. Decreased Apo B level and elevated HDL‐C and Hcy levels are independent risk factors. Early‐onset and late‐onset PD may have different progression mechanisms.

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“…This data is in agreement with the recent study performed by Choe et al (2021) reporting no associations between lipid levels and cognitive functioning in a longitudinal study on advanced PD patients. Conversely, in a cross-sectional study on early PD patients, Huang et al (2018) reported a strong association between higher serum TG levels and poorer executive and visuospatial functioning.…”

Section: Discussionmentioning

confidence: 92%

“…Although not entirely consistent, some studies suggested that subjects with high levels of cholesterol and low-density lipoproteins have a lower PD risk, thus supporting the role of statins as a risk factor for PD (Potashkin et al 2020;Fu et al 2020). To date only few studies have investigated the effects of dyslipidemia on cognitive performance in PD, reporting conflicting results (Choe et al 2021;Huang et al 2018;Mollenhauer et al 2019;Bakeberg et al 2021). Furthermore, most of the existing studies did not consider the sex-specific differences when evaluating possible associations between lipids levels and cognition.…”

Section: Introductionmentioning

confidence: 99%

Executive functioning and serum lipid fractions in Parkinson’s disease—a possible sex-effect: the PACOS study

et al. 2022

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The association between dyslipidemia and cognitive performance in Parkinson’s disease (PD) patients still needs to be clarified. Aim of the study was to evaluate the presence of possible associations between serum lipids fractions and executive dysfunction also exploring the sex-specific contribute of lipids level on cognition. Patients from the PACOS cohort, who underwent a complete serum lipid profile measures (total cholesterol-TC, low-density lipoprotein cholesterol-LDL, high-density lipoprotein cholesterol-HDL and triglycerides-TG) were selected. Adult Treatment Panel III guidelines of the National Cholesterol Education Program were used to classify normal/abnormal lipid fractions. Executive functioning was assessed with the Frontal Assessment Battery (FAB). Logistic regression was performed to assess associations between lipids fractions and FAB score. Correlations between lipids fractions and FAB score were explored. Sex-stratified analysis was performed. Three hundred and forty-eight PD patients (148 women; age 66.5 ± 9.5 years; disease duration 3.9 ± 4.9 years) were enrolled. Women presented significantly higher TC, LDL and HDL than men. In the whole sample, any association between lipid profile measures and FAB score was found. Among women, a positive association between hypertriglyceridemia and FAB score under cutoff was found (OR 3.4; 95%CI 1.29–9.03; p value 0.013). A statistically significant negative correlation was found between the FAB score and triglyceride serum levels (r = − 0.226; p value 0.005). Differently, among men, a statistically significant negative association between hypercholesterolemia and FAB score under cutoff (OR 0.4; 95%CI 0.17–0.84; p value 0.018) and between high LDL levels and FAB score under cutoff (OR 0.4; 95%CI 0.18–0.90; p value 0.027) were found. Our data suggest a sex-specific different role of lipids in executive functioning.

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Higher serum triglyceride levels are associated with Parkinson's disease mild cognitive impairment

Cited by 21 publications

References 7 publications

Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson’s disease

Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson’s disease

Correlations between blood lipid, serum cystatin C, and homocysteine levels in patients with Parkinson's disease

Executive functioning and serum lipid fractions in Parkinson’s disease—a possible sex-effect: the PACOS study

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