Higher Serum Undercarboxylated Osteocalcin and Other Bone Turnover Markers Are Associated With Reduced Diabetes Risk and Lower Estradiol Concentrations in Older Men

Yeap, Bu B.; Alfonso, Helman; Chubb, S. A. Paul; Gauci, Richard; Byrnes, Elizabeth; Beilby, John; Ebeling, Peter R.; Handelsman, David J.; Allan, Carolyn; Grossmann, Mathis; Norman, Paul; Flicker, Leon

doi:10.1210/jc.2014-3019

Cited by 92 publications

(76 citation statements)

References 47 publications

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“…Increasing data underlie the relevance of bone metabolism and turnover biomarker concentration on type 2 diabetes mellitus (T2DM) pathophysiology [25][26][27]. In particular, OC has been significantly related to glucose metabolism, through the increase of insulin release and sensitivity and energy expenditure, and reduction of visceral fat [24][25][26][27][28]29].…”

Section: Biological and Pre-analytical Variabilitymentioning

confidence: 99%

“…In particular, OC has been significantly related to glucose metabolism, through the increase of insulin release and sensitivity and energy expenditure, and reduction of visceral fat [24][25][26][27][28]29]. In a general population, an inverse relationship was found between OC and fasting plasma glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) [30].…”

Section: Biological and Pre-analytical Variabilitymentioning

confidence: 99%

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Biomarkers of Bone Turnover: Potential, Challenges and Pitfalls from the Laboratory Point of view

Vassalle¹

2016

Rheumatology

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Section: Biological and Pre-analytical Variabilitymentioning

confidence: 99%

Section: Biological and Pre-analytical Variabilitymentioning

confidence: 99%

Biomarkers of Bone Turnover: Potential, Challenges and Pitfalls from the Laboratory Point of view

Vassalle¹

2016

Rheumatology

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“…The ucOC form released in the circulation stimulates pancreatic β cells insulin secretion and also increases the insulin sensitivity in liver, muscle and adipose tissue [95,102,106]. In a large cohort of 2966 patients without CF, clinical data showed that higher serum ucOC and other bone turnover markers are associated with reduced diabetes risk and lower estradiol concentration [108]. Of note, in a pediatric CF population, dysglycaemia was shown to be associated with reduced bone mass accrual, in addition to recognized factors such as abnormal function, poor nutritional status and disease severity.…”

Section: Altered Bone-pancreas Loopmentioning

confidence: 99%

Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies

Jacquot

Delion²,

Gangloff³

et al. 2015

Osteoporos Int

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Mutations within the gene encoding for the chloride ion channel cystic fibrosis transmembrane conductance regulator (CFTR) results in cystic fibrosis (CF), the most common lethal autosomal recessive genetic disease that causes a number of long-term health problems, as the bone disease. Osteoporosis and increased vertebral fracture risk associated with CF disease are becoming more important as the life expectancy of patients continues to improve. The etiology of low bone density is multifactorial, most probably a combination of inadequate peak bone mass during puberty and increased bone losses in adults. Body mass index, male sex, advanced pulmonary disease, malnutrition and chronic therapies are established additional risk factors for CF-related bone disease (CFBD). Consistently, recent evidence has confirmed that CFTR plays a major role in the osteoprotegerin (OPG) and COX-2 metabolite prostaglandin E2 (PGE2) production, two key regulators in the bone formation and regeneration. Several others mechanisms were also recognized from animal and cell models contributing to malfunctions of osteoblast (cell that form bone) and indirectly of bone-resorpting osteoclasts. Understanding such mechanisms is crucial for the development of therapies in CFBD. Innovative therapeutic approaches using CFTR modulators such as C18 have recently shown in vitro capacity to enhance PGE2 production and normalized the RANKL-to-OPG ratio in human osteoblasts bearing the mutation F508del-CFTR and therefore potential clinical utility in CFBD. This review focuses on the recently identified pathogenic mechanisms leading to CFBD and potential future therapies for treating CFBD.

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“…In the process of postmenopausal osteoporosis, OCN can significantly increase. 27 After menopause, serum TRACP-5b significantly increases, due to ovarian dysfunction and the reduction of endogenous estrogen. Subsequently, bone resorption is greater than bone formation, and the incidence of …”

Section: Trabecular Bone-structure Testingmentioning

confidence: 99%

Mechanism of enhanced antiosteoporosis effect of circinal–icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate

Jiang¹,

Li²,

Zhang³

et al. 2015

IJN

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Background Circinal–icaritin (CIT), one new active aglycone of Epimedium , can exert a beneficial effect on osteoporotic bone. However, its low bioavailability limits its clinical efficacy for the treatment of osteoporosis. Materials and methods In this paper, suet oil (SO) was used to improve the oral bioavailability of CIT and enhance its antiosteoporosis effect and absorption. After oral administration of CIT together with SO, the CIT and SO self-assembled into nanomicelles under the action of sodium deoxycholate (DOC) by bile secretion. The antiosteoporosis effects of the CIT-SO-DOC nanomicelles were evaluated in osteoporotic rats by bone mineral density, serum biochemical markers, bone microarchitecture, bone biomechanical properties, and related protein and gene expressions. We examined the bioavailability of CIT and its nanomicelles in vivo, and subsequently the nanomicelles were verified using transmission electron microscopy. Finally, we evaluated absorption across a rat intestinal perfusion model. Results Compared with CIT, in the CIT-SO groups, protein and messenger ribonucleic acid expressions of osteoprotegerin were increased, while expressions of receptor activator of nuclear factor-κB ligand in bone tissue were decreased; bone-turnover markers in serum of hydroxyproline, alkaline phosphatase, tartrate-resistant acid phosphatase 5b, and receptor activator of nuclear factor-κB ligand levels were decreased, while osteoprotegerin and osteocalcin levels were increased; and trabecular bone mass, microarchitecture, and bone biomechanical strength were enhanced. The relative bioavailabilities of CIT-SO high dosage, CIT-SO medium dosage, and CIT-SO low dosage (area under concentration–time curve [AUC] 0–∞ ) compared with that of raw CIT high dosage, CIT medium dosage, and CIT low dosage (AUC 0–∞ ) were 127%, 121%, and 134%, respectively. The average particle size of CIT-DOC was significantly decreased after adding SO ( P <0.01), and the intestinal permeability coefficients of CIT-SO-DOC nanomicelles in the duodenum, jejunum, ileum, and colon were all significantly improved ( P <0.01). Conclusion The increased antiosteoporosis effects and bioavailability of CIT-SO-DOC self-assembled nanomicelles were due to an increase in absorption of CIT by reducing the particle sizes of CIT. SO may be a practical oral carrier for antiosteoporosis drugs with low bioavailability.

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Higher Serum Undercarboxylated Osteocalcin and Other Bone Turnover Markers Are Associated With Reduced Diabetes Risk and Lower Estradiol Concentrations in Older Men

Cited by 92 publications

References 47 publications

Biomarkers of Bone Turnover: Potential, Challenges and Pitfalls from the Laboratory Point of view

Biomarkers of Bone Turnover: Potential, Challenges and Pitfalls from the Laboratory Point of view

Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies

Mechanism of enhanced antiosteoporosis effect of circinal–icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate

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Higher Serum Undercarboxylated Osteocalcin and Other Bone Turnover Markers Are Associated With Reduced Diabetes Risk and Lower Estradiol Concentrations in Older Men

Cited by 92 publications

References 47 publications

Biomarkers of Bone Turnover: Potential, Challenges and Pitfalls from the Laboratory Point of view

Biomarkers of Bone Turnover: Potential, Challenges and Pitfalls from the Laboratory Point of view

Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies

Mechanism of enhanced antiosteoporosis effect of&nbsp;circinal&ndash;icaritin by self-assembled nanomicelles&nbsp;in vivo with suet oil and sodium deoxycholate

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Mechanism of enhanced antiosteoporosis effect of circinal–icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate