Higher stroke incidence in the patients with pancreatic cancer

Chan, Po-Chi; Chang, Wei‐Lun; Hsu, Min-Hsien; Yeh, Chung‐Hsin; Muo, Chih‐Hsin; Chang, Ko-Shih; Hsu, Chung Y.; Wu, Bor-Tsang; Lai, Ching-Hsiang; Lee, Ching-Hsiao; Ting, Hua; Sung, Fung‐Chang

doi:10.1097/md.0000000000010133

Cited by 16 publications

(19 citation statements)

References 22 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, we also analyzed the time sequences between the initiation of chemotherapy, development of aTE, and patient’s death. Several studies reported the peak incidence of ischemic stroke happened within first 6 months of cancer diagnosis [ 11 , 24 ] and the medial survival after ischemic stroke was around 1 to 4.5 months [ 15 , 16 ]. The peak incidence of aTE and survival outcome after the diagnosis of aTE was comparable with previous reports.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies are beginning to explore the association between pancreatic cancer and aTE [ 10 , 23 , 24 ]. However, due to the rarity of aTE and the inherent limitations imposed by the national registry data [ 24 ], data regarding the risk factors and the impact of aTE on survival outcome in patients with pancreatic cancer were limited. Palliative chemotherapy is the standard treatment for patients with unresectable or metastatic pancreatic cancer and unfortunately, the impact of chemotherapy on the overall incidence of aTE has not been thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence, Risk Factors, and Outcomes of Arterial Thromboembolism in Patients with Pancreatic Cancer Following Palliative Chemotherapy

Hung

Chen

et al. 2018

Cancers

View full text Add to dashboard Cite

Background: Few studies have explored the association between pancreatic cancer and arterial thromboembolism (aTE). Methods: A total of 838 consecutive patients receiving palliative chemotherapy for pancreatic cancer between 2010 and 2016 were retrospectively enrolled. The clinical characteristics of patients were analyzed to determine the incidence, risk factors, and survival outcome of aTE in patients with pancreatic cancer. Results: aTE occurred in 42 (5.0%) of 838 patients. Patients with aTE had a worse survival outcome than those without (5.1 months versus 7.8 months, hazard ratio 1.53, 95% confidence interval [CI]: 1.12–2.09). Stage IV disease, high aspartate transaminase level, and comorbidity with hypertension or atrial fibrillation were four independent predictors of aTE. A concise predictive model stratified patients into low (0–1 predictor), intermediate (2 predictors), and high (3–4 predictors) risk groups. The hazard ratios for the comparison of patients in intermediate and high risk groups with those in low risk group were 4.55 (95% CI: 2.31–8.98), and 13.3 (95% CI: 5.63–31.6), respectively. Conclusion: Patients with pancreatic cancer undergoing palliative chemotherapy have an increased risk of aTE. A predictive model showed that patients presented with 3 or 4 predictors had the highest risk for developing aTE.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence, Risk Factors, and Outcomes of Arterial Thromboembolism in Patients with Pancreatic Cancer Following Palliative Chemotherapy

Hung

Chen

et al. 2018

Cancers

View full text Add to dashboard Cite

show abstract

“…For example, the annual age-standardized incidence rate of diabetes was <1% across Taiwanese population (Jiang et al, 2012). Additionally, the age and gender-adjusted incidence of AMI was 50.7/100,000 persons in 2015 (Lee et al, 2018) and the estimated stroke incidence was 12.3/1000 person-years (Chan et al, 2018). Our results highlight the need for studies to determine the impact of TB disease on risk of NCDs; such studies will require substantial follow-up time and a control group without TB disease.…”

Section: Discussionmentioning

confidence: 99%

Post-tuberculosis incidence of diabetes, myocardial infarction, and stroke: Retrospective cohort analysis of patients formerly treated for tuberculosis in Taiwan, 2002–2013

Salindri

Wang

Lin

et al. 2019

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Objectives:To estimate the incidence of diabetes, acute myocardial infarction (AMI), and stroke; and to determine factors associated with diabetes, AMI, and stroke incidence among patients previously treated for tuberculosis (TB) disease.Methods:A retrospective cohort study was conducted among non-pediatric TB patients registered in the Taiwan National Health Insurance Research Database (NHIRD) from 2002–2013. Diabetes, AMI, and stroke incidence were defined by International Classification of Diseases (ICD)-9 codes, drug prescriptions, and records of patient’s clinic visits. Cox proportional hazard models were used to estimate the hazard rate ratio (HR) of incident diabetes, AMI, and stroke.Results:From 2002–2013, there were 157,444 patients treated for TB registered in NHIRD. Among 129,453 patients with no prior history of diabetes, the age-adjusted incidence rate (IR) of diabetes was 3.85 (95%CI 3.70–4.01) per 1000 person-years. Among 143,646 patients with no prior history of AMI, the age-adjusted IR of AMI as 3.26 (95%CI 3.13–3.40). Among 118,774 patients with no prior history of stroke, the age-adjusted IR of stroke was 16.08 (95%CI 15.76–16.32).Conclusions:Chronic non-communicable disease risk factors like dyslipidemia, hypertension, and chronic kidney disease diagnosed before time of TB diagnosis were predictive of diabetes, AMI, and stroke incidence.

show abstract

“…Cancer cells can activate the body's coagulation mechanism by releasing many tissue factors, cancer-associated procoagulant, and cyokines, and cancer cells also can interact with platelets to release ADP, arachidonic acid, 5-HT, and other substances to promote blood coagulation. Eventually, the body will be hypercoagulable [23][24][25][26][27]. Bang's recent research showed circulating tumor extracellular vesicles, especially in adenocarcinoma patients, also played a vital role in cancer-associated thrombosis and tumor progression [28,29].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke

Lin

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Objective. To research the clinical characteristics and risk factors of lung cancer-associated acute ischemic stroke (LCA-AIS). Methods. Patients diagnosed with LCA-AIS, simple lung cancer, and simple AIS were enrolled. The primary information, laboratory results, tumor histopathology, neurological deficits, and survival time of the patients were collected and analyzed. Results. (1) In the LCA-AIS group, the pathology of 69.56% patients were adenocarcinoma, and the proportion of poorly differentiated patients was significantly more than that in moderately differentiated or highly differentiated. The number of stage IV lung cancer patients in the LCA-AIS group was significantly more common than in other stages. (2) 56.52% of patients with lung cancer were diagnosed before AIS, and the peak of AIS attack was 1–6 months after the diagnosis of lung cancer. (3) The independent risk factors of LCA-AIS were CYFRA-211 (OR 1.070; 95% confidence interval 1.005, 1.139; p=0.035), TT (OR 1.275; 95% confidence interval 1.089, 1.493; p=0.003), and Hct (OR 0.878; 95% confidence interval 0.779, 0.990; p=0.034), making ROC curve, suggesting the area under the curve is 0.871. (4) The neurological deficit of patients in the LCA-AIS group was similar to the simple AIS group and could not be identified by the severity of neurological deficits. (5) The median survival time of LCA-AIS group patients was five months (95% confidence interval 3.796, 6.204). There were statistical differences in survival time between LCA-AIS group and simple AIS group patients (p<0.001).Conclusions. The interaction between lung cancer and AIS may shorten patients’ life expectancy and worsen their quality of life.

show abstract

Higher stroke incidence in the patients with pancreatic cancer

Abstract: Supplemental Digital Content is available in the text

Cited by 16 publications

References 22 publications

Incidence, Risk Factors, and Outcomes of Arterial Thromboembolism in Patients with Pancreatic Cancer Following Palliative Chemotherapy

Incidence, Risk Factors, and Outcomes of Arterial Thromboembolism in Patients with Pancreatic Cancer Following Palliative Chemotherapy

Post-tuberculosis incidence of diabetes, myocardial infarction, and stroke: Retrospective cohort analysis of patients formerly treated for tuberculosis in Taiwan, 2002–2013

Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke

Contact Info

Product

Resources

About